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TBXA2R encodes a member of the G protein-coupled receptor family. Zusätzlich bieten wir Ihnen Thromboxane A2 Receptor Kits (17) und Thromboxane A2 Receptor Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Thromboxane A2 receptor is expressed in both vagal and spinal neurons. Thromboxane A(2) may elicit stronger vagal or parasympathetic reflexes in the rabbit when released during tissue trauma depending on the location of release.
Data suggest that in hypoxic pulmonary hypertension, loss of site-specific phosphorylation of TBXA2R results in agonist hyper-responsiveness; Ser324 appears to be primary residue phosphorylated during protein kinase A activation of TBXA2R.
TXA2R rs1131882TT genotype is associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients.
We demonstrate that Trp334 in the TPbeta C-terminus is critical for the CCT7 (zeige CCT7 Antikörper) interaction and plays an important role in TPbeta maturation and cell-surface expression.
TBXA2R +924C/T polymorphism is associated with asthma risk
A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 (zeige TBC1D9 Antikörper) C3435T, TBXA2R (rs1131882), and PLA2G7 (zeige Lp-PLA2 Antikörper) (rs1051931-rs7756935) polymorphisms.
Data suggest that thromboxane A2/TBXA2R signaling promotes multiple myeloma cell proliferation by reducing delay at G2/M phase via up-regulation of MAP kinase (zeige MAPK1 Antikörper) pathway, up-regulation of cyclin B1 (zeige CCNB1 Antikörper)/CDK1 (zeige CDK1 Antikörper) expression, and down-regulation of apoptosis.
The results of this study show that TXA2R polymorphisms may affect platelet function and the risk of developing cerebral ischemia.
TXA2 receptor associated with lipid rafts in platelets is important for functional platelet responses to TXA2
Data suggest TBXA2R requires Ser324 for normal activity; Ser324A mutant is insensitive to activation by protein kinase A/cell hypoxia, has high affinity for agonists (thromboxane A2/analogs), and participates in agonist-induced calcium mobilization.
TXA2 should be regarded as a critical molecule in COX-2 (zeige COX2 Antikörper)-mediated tumor growth and a valuable target against lung cancer.
Human thromboxane A2 receptor genetic variant V80E exhibited reduced platelet activation whereas A160T demonstrated platelet hyperactivity.
platelet GP6 (zeige GP6 Antikörper) and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation
Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation.
PKCalpha (zeige PKCa Antikörper) deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression.
Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism.
Blocking the expression of the thromboxane receptor significantly suppresses the prothrombotic effect of C-reactive protein (zeige CRP Antikörper).
The thromboxane A(2) receptor agonist 11-deoxy PGF (zeige PTGFR Antikörper)(2alpha) can partially alleviate embryo crowding in the Lpar3 (zeige LPAR3 Antikörper)((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3 (zeige LPAR3 Antikörper)((-/-)) females.
We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow.
thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury
Thromboxane A2 receptor activation via PKC-zeta (zeige PRKCZ Antikörper)-mediated NAD(P)H (zeige NQO1 Antikörper) oxidase activation increases superoxide and peroxynitrite, resulting in eNOS (zeige NOS3 Antikörper) uncoupling in endothelial cells.
thromboxane synthase, prostacyclin synthase (zeige PTGIS Antikörper) and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene.
thromboxane A2 receptor
, prostanoid TP receptor
, TXA2 receptor
, thromboxane prostanoid
, Thromboxane receptor