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The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Zusätzlich bieten wir Ihnen Sphingosine Kinase 1 Proteine (14) und Sphingosine Kinase 1 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SPHK1 Primary Antibody für IHC (p), WB - ABIN391346
Nayak, Huo, Kwang, Pushparaj, Kumar, Ling, Dheen: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. in Neuroscience 2010
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Human Polyclonal SPHK1 Primary Antibody für EIA, WB - ABIN359437
Nava, Lacana, Poulton, Liu, Sugiura, Kono, Milstien, Kohama, Spiegel: Functional characterization of human sphingosine kinase-1. in FEBS letters 2000
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Human Polyclonal SPHK1 Primary Antibody für EIA, IHC (p) - ABIN359438
Li, Yu, Xia, Zhang, Weng, Zheng, Kong, Hu, Zeng, Zeng, Li, Li, Song: Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009
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Human Polyclonal SPHK1 Primary Antibody für EIA, WB - ABIN359439
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
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Human Polyclonal SPHK1 Primary Antibody für ELISA, WB - ABIN314839
Igarashi, Okada, Hayashi, Fujita, Jahangeer, Nakamura: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. in The Journal of biological chemistry 2003
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Human Polyclonal SPHK1 Primary Antibody für WB - ABIN391345
Hayashi, Nakagami, Takami, Koriyama, Mori, Tamai, Sun, Nagao, Morishita, Kaneda: FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. in Arteriosclerosis, thrombosis, and vascular biology 2009
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Mouse (Murine) Polyclonal SPHK1 Primary Antibody für WB - ABIN4620349
Kihara, Ikeda, Kariya, Lee, Lee, Igarashi: Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. in The Journal of biological chemistry 2003
Human Polyclonal SPHK1 Primary Antibody für EIA, WB - ABIN782886
Kohama, Olivera, Edsall, Nagiec, Dickson, Spiegel: Molecular cloning and functional characterization of murine sphingosine kinase. in The Journal of biological chemistry 1998
Human Polyclonal SPHK1 Primary Antibody für ELISA, WB - ABIN308402
Kase, Hattori, Jojima, Okayasu, Tomizawa, Suzuki, Banba, Monden, Satoh, Akimoto, Kasai: Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells. in Life sciences 2007
Sk1 and Sk2 (zeige KCNN2 Antikörper) are not redundant in biological function and are essential for diverse physiological functions in Drosophila
SPHK/phyto-S1P (zeige MBTPS1 Antikörper) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (zeige MBTPS1 Antikörper) system activates in parallel to viral replication and the inflammatory process induced by the virus.
These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.
By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.
SphK1 is regulated by PDGF (zeige PDGFA Antikörper)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (zeige EGR1 Antikörper), promoting cell proliferation.
Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (zeige MBTPS1 Antikörper) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.
demonstrated the roles played by miR (zeige MLXIP Antikörper)-144-3p and FN1 (zeige FN1 Antikörper) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (zeige F9 Antikörper)
SphK1 is associated with the proliferation and invasiveness of CRC (zeige CALR Antikörper) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (zeige CALR Antikörper).
The levels of SphK1 were significantly increased in triple-negative breast cancer patients compared with normal controls. SphK1 knockdown with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion, suggesting that SphK1 has an important role in TNBC.
SPHK1 mRNA is up-regulation in colorectal cancer.
Found that upregulation of SphK1 expression in the stiff substrate is dominant in metastatic cancer cells but not in primary cancer cells. These results suggest that alterations in the mechanical environment of the extracellular matrix surrounding the tumor cells actively regulate cellular properties such as secretion, which in turn, may contribute to cancer progression.
In conclusion, these data suggested that HuR (zeige ELAVL1 Antikörper) bound to SphK1 mRNA and played a crucial role in TGF-beta1 (zeige TGFB1 Antikörper)-induced hepatic stellate cell activation.
Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (zeige S1PR1 Antikörper) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.
These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (zeige AGER Antikörper)/SphK1 signaling pathway in db/db (zeige LEPR Antikörper) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.
Keratinocyte-specific deletion of Traf2 (zeige TRAF2 Antikörper), but not Sphk1 deficiency, disrupted TNF (zeige TNF Antikörper) mediated NF-kappaB (zeige NFKB1 Antikörper) and MAP kinase (zeige MAPK1 Antikörper) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
SphK1 dependent PKC-delta (zeige PKCd Antikörper) activation plays an important role in promoting NF-kappaB (zeige NFKB1 Antikörper) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (zeige PKCd Antikörper) activation might be a potential therapeutic strategy for this disease.
Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (zeige HMGB1 Antikörper) cytoplasmic translocation in liver cells.
Collectively, our results demonstrate that PF-543 exerts potent anti-CRC (zeige SCRIB Antikörper) activity in vitro and in vivo.
transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists
Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.
Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (zeige MC4R Antikörper)-SphK1 signaling.
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, sphingosine kinase 1
, sphingosine kinase I
, SK 1
, SPK 1