Signal-Regulatory Protein alpha Proteine (SIRPA)

The protein encoded by SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen SIRPA Antikörper (218) und SIRPA Kits (16) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRPA 140885 P78324
SIRPA 19261 P97797
SIRPA 25528 P97710
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Showing 10 out of 32 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Human Cells Human His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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HOST_HEK-293 Cells Human His tag   250 μg Anmelden zum Anzeigen 6 bis 8 Tage
2.921,70 €
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HOST_Human Cells Ratte His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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HOST_Human Cells Maus Fc Tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
487,62 €
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HOST_Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
624,76 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details
HOST_Human Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
166,67 €
Details

SIRPA Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , , ,
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Mouse (Murine) , ,
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Rat (Rattus) , ,
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Weitere Proteine zu Signal-Regulatory Protein alpha (SIRPA) Interaktionspartnern

Human Signal-Regulatory Protein alpha (SIRPA) Interaktionspartner

  1. CD47 (zeige CD47 Proteine), TSP1 (zeige THBS1 Proteine), and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.

  2. exploited by Hepatitis E virus to negative regulated IFN-beta (zeige IFNB1 Proteine) of the host innate immune system to promote viral infection

  3. Data suggest a reduction in the CD47 antigen (zeige CD47 Proteine)/signal-regulatory protein alpha (SIRPalpha) pathway by programmed cell death protein 1 (PD-1 (zeige PDCD1 Proteine)) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).

  4. agents that block the CD47 (zeige CD47 Proteine):SIRP-alpha engagement are attractive therapeutic targets as a monotherapy or in combination with additional immune-modulating agents for activating antitumor T cells in vivo

  5. the data suggest that combinatorial actions of ADAM10 (zeige ADAM10 Proteine) and gamma-secretase on SIRPalpha cleavage promote inflammatory signaling.

  6. Loss of cell surface CD47 (zeige CD47 Proteine) clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  7. Velcro" engineering of high affinity CD47 (zeige CD47 Proteine) ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  8. Combinatorial expression of NKX2-5 (zeige NKX2-5 Proteine), SIRPA, VCAM1 (zeige VCAM1 Proteine) and CD34 (zeige CD34 Proteine) can be used to define discrete stages of cardiovascular cell lineage differentiation.

  9. The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG (zeige SIRPG Proteine).

  10. These results suggest that thrombospondin-1 (zeige THBS1 Proteine) binding to SIRP-alpha on nonphagocytic cells activates NADPH oxidase (zeige NOX1 Proteine), limits vasodilation, and promotes renal ischemia reperfusion injury.

Mouse (Murine) Signal-Regulatory Protein alpha (SIRPA) Interaktionspartner

  1. these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47 (zeige CD47 Proteine)-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity

  2. Data provide evidence that SIRPalpha-mediated phagocytosis is not a major determinant in prion (zeige PRNP Proteine) disease pathogenesis.

  3. Treg cells protect dopaminergic neurons against MPP+ neurotoxicity by a cell-to-cell contact mechanism underlying CD47 (zeige CD47 Proteine)-SIRPA interaction and Rac1/Akt (zeige AKT1 Proteine) activation.

  4. In conclusion, our data suggest that SIRPalpha signaling through SHP-2 (zeige PTPN11 Proteine)-PI3K-Akt2 (zeige AKT2 Proteine) strongly influences osteoblast differentiation from bone marrow stromal cells.

  5. These results indicate an important role for CD47 (zeige CD47 Proteine)-SIRPalpha interactions in innate control of malaria and suggest novel targets for intervention.

  6. TLR5 (zeige TLR5 Proteine) mediates CD172a(+) intestinal lamina propria dendritic cell induction of Th17 cells.

  7. SIRPalpha intrinsic to CD11c (zeige ITGAX Proteine)(+) dendritic cells is essential for homeostasis of conventional dendritic cells in the secondary lymphoid organs and skin.

  8. Loss of cell surface CD47 (zeige CD47 Proteine) clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  9. Velcro" engineering of high affinity CD47 (zeige CD47 Proteine) ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  10. Polymorphism in the innate immune receptor SIRPalpha controls CD47 (zeige CD47 Proteine) binding and autoimmunity in the nonobese diabetic mouse.

SIRPA Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Genbezeichner und Symbole assoziert mit SIRPA

  • signal-regulatory protein alpha (SIRPA)
  • signal-regulatory protein beta 1 (SIRPB1)
  • signal-regulatory protein alpha (Sirpa)
  • AI835480 Protein
  • Bit Protein
  • CD172a Protein
  • MFR Protein
  • MYD-1 Protein
  • P84 Protein
  • Ptpns1 Protein
  • SHP-1 Protein
  • SHPS-1 Protein
  • SHPS1 Protein
  • SIRP Protein
  • SIRP-A1 Protein
  • SIRP-B1 Protein
  • SIRPA Protein
  • swc3 Protein

Bezeichner auf Proteinebene für SIRPA

signal-regulatory protein alpha , protein tyrosine phosphatase, non-receptor type substrate 1 , MyD-1 antigen , signal regulatory protein alpha , tyrosine-protein phosphatase non-receptor type substrate 1-like , CD172 antigen-like family member A , brain-immunoglobulin-like molecule with tyrosine-based activation motifs , inhibitory receptor SHPS-1 , macrophage fusion receptor , myd-1 antigen , tyrosine phosphatase SHP substrate 1 , tyrosine-protein phosphatase non-receptor type substrate 1 , SHP substrate 1 , brain Ig-like molecule with tyrosine-based activation motifs , brain immunological-like with tyrosine-based motifs , mSIRP-alpha1 , myD-1 antigen , signal-regulatory protein alpha-1 , sirp-alpha-1 , Brain immunoglobulin like protein with tyrosine - based activation motifs , Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1) , Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1) , macrophage membrane protein MFP150 , swine workshop cluster 3 antigen , SHPS-1

GENE ID SPEZIES
419267 Gallus gallus
458039 Pan troglodytes
529990 Bos taurus
609452 Canis lupus familiaris
717811 Macaca mulatta
771734 Gallus gallus
100067339 Equus caballus
100351485 Oryctolagus cuniculus
100400378 Callithrix jacchus
100456232 Pongo abelii
100590224 Nomascus leucogenys
140885 Homo sapiens
19261 Mus musculus
25528 Rattus norvegicus
494566 Sus scrofa
327666 Bos taurus
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