Signal-Regulatory Protein alpha (SIRPA) (AA 31-370) (Active) protein (Fc Tag) Protein
- Target Alle SIRPA Proteine anzeigen
- Biologische Aktivität
- AA 31-370
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses SIRPA Protein ist gelabelt mit Fc Tag.
- AA 31-370
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.5 kDa. The protein migrates as 70-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- >95 % as determined by SDS-PAGE.
- 0.22 μm filtered
- Less than 1.0 EU per μg by the LAL method.
Signal-Regulatory Protein alpha (SIRPA) (AA 32-513) protein (rho-1D4 tag) Protein
Crystallography grade SIRPA Spezies: Maus Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
- Nur für Forschungszwecke einsetzbar
- 50 mM Tris, 100 mM Glycine, pH 7.5
- Please avoid repeated freeze-thaw cycles.
- -20 °C
- Informationen zur Lagerung
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 206, Issue 4, pp. 712-721, (2021) (PubMed).
: "Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity." in: Cancer immunology, immunotherapy : CII, (2020) (PubMed).
: "A novel fully human anti-CD47 antibody as a potential therapy for human neoplasms with good safety." in: Biochimie, Vol. 151, pp. 54-66, (2018) (PubMed).
- Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 206, Issue 4, pp. 712-721, (2021) (PubMed).
- Andere Bezeichnung
- SIRP alpha (SIRPA Produkte)
- BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, SIRPA, SIRP-A1, SIRP-B1, AI835480, Bit, CD172a, Ptpns1, SHP-1, SHPS-1, swc3, signal regulatory protein alpha, myeloperoxidase, signal-regulatory protein alpha, tyrosine-protein phosphatase non-receptor type substrate 1, SIRPA, MPO, LOC458039, LOC100400378, LOC100590224, Sirpa
- Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
- 63.9 kDa
- NCBI Accession