Sialidase 1 (Lysosomal Sialidase) Proteine (NEU1)

The protein encoded by NEU1 is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Zusätzlich bieten wir Ihnen NEU1 Antikörper (56) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NEU1 4758 Q99519
NEU1 18010 O35657
NEU1 24591  
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Top NEU1 Proteine auf antikoerper-online.de

Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$407.00
Details
Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$522.50
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
Details
Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,008.50
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,008.50
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,014.00
Details

NEU1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Sialidase 1 (Lysosomal Sialidase) (NEU1) Interaktionspartnern

Mouse (Murine) Sialidase 1 (Lysosomal Sialidase) (NEU1) Interaktionspartner

  1. Neu1 (zeige NEURL Proteine) inhibits lipolysis induced by beta-adrenergic stimulation in adipocytes via interactions with Plin1 (zeige PLIN1 Proteine) on lipid drops.

  2. Neu1 (zeige NEURL Proteine) is the only lysosomal multienzyme complex gene underexpressed in mucopolysaccharidosis type I mice.

  3. Neu1 (zeige NEURL Proteine) desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.

  4. Data indicate a role for neuraminidase 1 (Neu1) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)) interaction and endotoxemia.

  5. elastin (zeige ELN Proteine)-derived peptides as an enhancer of atherogenesis and defines the Neuraminidase 1/PI3Kgamma (zeige PIK3CG Proteine) signalling pathway as a key mediator

  6. significant increases in Col1a1 (zeige COL1A1 Proteine), serine/threonine-protein kinase 1, Ctnnb1 (zeige CTNNB1 Proteine), CSRNP1 (zeige CSRNP1 Proteine), Ddit4 (zeige DDIT4 Proteine), Cyp2e1 (zeige CYP2E1 Proteine), and Krit1 (zeige KRIT1 Proteine) expressions and great decreases inreceptor D2, Neu1 (zeige NEURL Proteine), and Dhcr7 (zeige DHCR7 Proteine) expressions following long-term exposure to TiO2 NPs (zeige NPS Proteine)

  7. NEU1 (zeige NEURL Proteine) deficiency has a role in determining amyloid precursor protein (zeige APP Proteine) levels and amyloid-beta secretion via deregulated lysosomal exocytosis

  8. Neu1 (zeige NEURL Proteine) sialidase and matrix metalloproteinase-9 (zeige MMP9 Proteine) cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 (zeige TLR7 Proteine) and -9 activation, cellular signaling and pro-inflammatory responses.

  9. The activity of NEU1 (zeige NEURL Proteine) was preferentially higher in epididymal fat and lower in the livers of two strains of obese and diabetic mice.

  10. these studies identify Neu1 (zeige NEURL Proteine) as a novel component of the signaling pathways of energy metabolism and glucose uptake.

Human Sialidase 1 (Lysosomal Sialidase) (NEU1) Interaktionspartner

  1. EGFR (zeige EGFR Proteine) protein, human is predictive of adjuvant chemo response. Also, It is a prognostic factor.

  2. Data suggest that mutations c.90delC (p.Tyr30Ter) and c.572A>T (p.Asp191Val) of the NFU1 (zeige NFU1 Proteine) gene probably underlie the pathogenesis of multiple mitochondrial dysfunction syndrome (MMDS).

  3. Elevated NEU1 expression alters functional activities of distinct lung cell types in vitro and recapitulates lymphocytic infiltration and collagen accumulation in vivo, consistent with mechanisms implicated in lung fibrosis.

  4. initial treatment with an EGFR (zeige EGFR Proteine)-TKI is a reasonable option for patients presenting with EGFR (zeige EGFR Proteine) mutation-positive NSCLC and a CM.

  5. miR (zeige MLXIP Proteine)-125b functions as an oncogene (zeige RAB1A Proteine) in gastric cancer and represents a new potential therapeutic target for gastric cancer.

  6. NEU1 siRNA can effectively inhibit proliferation, apoptosis, and invasion of human ovarian cancer cells by targeting lysosome and oxidative phosphorylation signaling, which can serve as a new target ovarian cancer treatment

  7. How the point mutations of the neuraminidase (zeige NEU Proteine) sequences affected the susceptibility of H9N2 virus to oseltamivir is still to be determined and deserve further investigations

  8. Basal Neu-1 catalytic activity is strongly increased in aged cells.

  9. Neu1 desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.

  10. Flagellin (zeige FliC Proteine) drives NEU1 to desialylate MUC1 (zeige MUC1 Proteine), thereby increasing its adhesiveness for Pseudomonas aeruginosa and its shedding

Cow (Bovine) Sialidase 1 (Lysosomal Sialidase) (NEU1) Interaktionspartner

  1. NEU1 gene is not responsible for the lysosomal storage disease of Japanese Black cattle.

NEU1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.

Genbezeichner und Symbole assoziert mit NEU1

  • neuraminidase 1 (NEU1)
  • neuraminidase 1 (lysosomal sialidase) L homeolog (neu1.L)
  • neuraminidase 1 (neu1)
  • neuraminidase 1 (Neu1)
  • AA407268 Protein
  • AA407316 Protein
  • Aglp Protein
  • Apl Protein
  • Bat-7 Protein
  • Bat7 Protein
  • G9 Protein
  • Map-2 Protein
  • MGC81958 Protein
  • NANH Protein
  • Neu Protein
  • Neu-1 Protein
  • SIAL1 Protein

Bezeichner auf Proteinebene für NEU1

G9 sialidase , N-acetyl-alpha-neuraminidase 1 , acetylneuraminyl hydrolase , exo-alpha-sialidase , lysosomal sialidase , sialidase-1 , sialidase 1 (lysosomal sialidase) , neuraminidase , isotocin , Isotocin-neurophysin IT 1 , neuraminidase 1 , sialidase-1-like , HLA-B-associated transcript 7 , sialidase 1

GENE ID SPEZIES
4758 Homo sapiens
444511 Xenopus laevis
471968 Pan troglodytes
481717 Canis lupus familiaris
505554 Bos taurus
716740 Macaca mulatta
100124381 Sus scrofa
100136555 Salmo salar
100342130 Oryctolagus cuniculus
100408501 Callithrix jacchus
100595428 Nomascus leucogenys
18010 Mus musculus
24591 Rattus norvegicus
100728899 Cavia porcellus
Ausgewählte Anbieter für NEU1 Proteine (NEU1)
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