anti-SET Domain, Bifurcated 1 (SETDB1) Antikörper

SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. Zusätzlich bieten wir Ihnen SETDB1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SETDB1 689883  
SETDB1 9869 Q15047
SETDB1 84505  
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Top anti-SETDB1 Antikörper auf antikoerper-online.de

Showing 10 out of 118 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Western blot analysis of anti-SETDB1 Pab(ABIN387924) in Ramos cell line lysate (35 µg/lane). SETDB1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Western blot analysis of SETDB1(arrow) using rabbit polyclonal SETDB1 Antibody (C-term) (ABIN387924). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the SETDB1 gene (Lane 2) (Origene Technologies). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IF, WB Immunofluorescence of monoclonal antibody to SETDB1 on HeLa cell (antibody concentration 10 µg/mL). SETDB1 monoclonal antibody (M07), clone 4A3 Western Blot analysis of SETDB1 expression in SW-13. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert BP, ChIP, IP, in vitro, Neut, WB Western Blot: SETDB1 Antibody [NBP2-20321] - Sample (30 ug of whole cell lysate) A: U87-MG 5% SDS PAGE gel, diluted at 1:2000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Maus Unkonjugiert ELISA, WB Figure 1: Western blot analysis using SETDB1 mouse mAb against MCF-7 (1) ,T47D (2), HEK293 (3), JURKAT (4), NIH/3T3 (5) and F9 (6) cell lysate. 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$393.80
Details
Human Maus Unkonjugiert ICC, ELISA, WB Figure 1: Immunofluorescence analysis of LOVO cells using SETDB1 mouse mAb (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Figure 2: Western blot analysis using SETDB1 mouse mAb against MCF-7 (1) ,T47D (2), HEK293 (3), JURKAT (4), NIH/3T3 (5), F9 (6), RAW246.7 (7) and Cos7 (8) cell lysate. 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$393.80
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: SETDB1 Antibody [NBP1-84790] - Staining of human colon shows strong nuclear, cytoplasmic and membranous positivity in glandular cells. Immunocytochemistry/Immunofluorescence: SETDB1 Antibody [NBP1-84790] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli, plasma membrane & cytoplasm. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$450.34
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB   100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details

SETDB1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-SETDB1 Antikörper

  1. Human Polyclonal SETDB1 Primary Antibody für ELISA, IHC - ABIN4353068 : Schultz, Ayyanathan, Negorev, Maul, Rauscher: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. in Genes & development 2002 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal SETDB1 Primary Antibody für ICC, IF - ABIN4353070 : Ceol, Houvras, Jane-Valbuena, Bilodeau, Orlando, Battisti, Fritsch, Lin, Hollmann, Ferré, Bourque, Burke, Turner, Uong, Johnson, Beroukhim, Mermel, Loda, Ait-Si-Ali, Garraway, Young, Zon: The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. in Nature 2011 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal SETDB1 Primary Antibody für ELISA, WB - ABIN967016 : Rosendorff, Sakakibara, Lu, Kieff, Xuan, DiBacco, Shi, Shi, Gill: NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal SETDB1 Primary Antibody für ELISA, WB - ABIN969393 : Gevaert, Staes, Van Damme, De Groot, Hugelier, Demol, Martens, Goethals, Vandekerckhove: Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. in Proteomics 2005 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal SETDB1 Primary Antibody für IF (p), IHC (p) - ABIN1387645 : Marco, Kisliouk, Tabachnik, Weller, Meiri et al.: DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on ... in Diabetes 2016 (PubMed)

  6. Human Polyclonal SETDB1 Primary Antibody für BP, ChIP - ABIN4353071 : Skuland, Ovrevik, Låg, Schwarze, Refsnes: Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling. in Toxicology and applied pharmacology 2014 (PubMed)

Weitere Antikörper gegen SETDB1 Interaktionspartner

Cow (Bovine) SET Domain, Bifurcated 1 (SETDB1) Interaktionspartner

  1. SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.

Human SET Domain, Bifurcated 1 (SETDB1) Interaktionspartner

  1. these data identify a critical functional role for ATF7IP (zeige ATF7IP Antikörper) in heterochromatin formation by regulating SETDB1 abundance in the nucleus.

  2. SETDB1 triggers silencing of retrotransposons to inhibit the interferon (zeige IFNA Antikörper) response in acute myeloid leukemia (zeige BCL11A Antikörper) cells.

  3. analysis of a 1q21.3 deletion encompassing SETDB1 that provides further support for the role of chromatin modifiers in the etiology of autism spectrum disorder

  4. SETDB1 protein expression was significantly associated with poor survival and was related to TNM (zeige ODZ1 Antikörper) stage.

  5. SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain. This ubiquitination is directly catalyzed by UBE2E family of E2 enzymes in an E3-independent manner while the conjugated-ubiquitin (Ub) is protected from active deubiquitination.

  6. These results suggest that the ubiquitination of SETDB1 at lysine 867 controls the expression of its target gene by activating its H3K9 methyltransferase activity.

  7. Authors observed several complementary mechanisms contributing to the upregulation of SETDB1 in HCC (zeige FAM126A Antikörper) cells. Besides copy number gains at the SETDB1 gene locus at chromosome 1q21 enhanced SETDB1 transcription mediated by the transcription factor SP1 (zeige SP1 Antikörper) could be detected.

  8. BRCA1 and SETDB1 stand out as the most significant prognostic markers in this group of patients

  9. These results suggest that SETDB1- mediated FosB (zeige FOSB Antikörper) expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy.

  10. SETDB1 mutations are associated with malignant pleural mesotheliomas.

Mouse (Murine) SET Domain, Bifurcated 1 (SETDB1) Interaktionspartner

  1. the SETDB1 repressor complex shields neuronal genomes from excess CTCF (zeige CTCF Antikörper) genome organizer binding and is critically required for structural maintenance of the protocadherin locus topologically associated domain

  2. The results identify Setdb1 as a newly discovered meiotic and embryonic competence factor safeguarding genome integrity at the onset of life.

  3. SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain. This ubiquitination is directly catalyzed by UBE2E family of E2 enzymes in an E3-independent manner while the conjugated-ubiquitin (Ub) is protected from active deubiquitination.

  4. study identifed ESET as first trimethylated H3K9 histone methyltransferase playing a crucial role in T cell development

  5. Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.

  6. SETDB1 maintains silencing of intracisternal A particle, but in the absence of DNMT1 (zeige DNMT1 Antikörper), prolonged binding of NP95 (zeige UHRF1 Antikörper) to hemimethylated DNA transiently disrupts SETDB1-dependent H3K9me3 deposition.

  7. Deletion of Setdb1 led to enlarged Meckel's cartilage. Chondrocytes from the Meckel's cartilage of Setdb1 mutant showed increased in size.

  8. Setdb1 is a maternal-effect (zeige NLRP5 Antikörper) gene that controls meiotic progression and is essential for early embryogenesis. Setdb1 is an important regulator of Cdc14b (zeige CDC14B Antikörper).

  9. The currently identified reciprocal action between SETDB1 and PRC2 reveals a novel mechanism underlying ES cell pluripotency and differentiation regulation.

  10. regulates cancer cell growth via methylation of p53 (zeige TP53 Antikörper)

SETDB1 Antigen-Profil

Protein Überblick

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.

Genbezeichner und Symbole assoziert mit SETDB1

  • SET domain, bifurcated 1 (Setdb1) Antikörper
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (MLLT11) Antikörper
  • SET domain bifurcated 1 (SETDB1) Antikörper
  • histone-lysine N-methyltransferase SETDB1 (LOC100120014) Antikörper
  • histone-lysine N-methyltransferase SETDB1 (LOC100461671) Antikörper
  • SET domain, bifurcated 1a (setdb1a) Antikörper
  • SET domain bifurcated 1 L homeolog (setdb1.L) Antikörper
  • AU022152 Antikörper
  • ESET Antikörper
  • fc07d03 Antikörper
  • H3-K9-HMTase4 Antikörper
  • KG1T Antikörper
  • KMT1E Antikörper
  • mKIAA0067 Antikörper
  • NV10069 Antikörper
  • SETDB1 Antikörper
  • si:ch211-81a5.6 Antikörper
  • TDRD21 Antikörper
  • wu:fc07d03 Antikörper

Bezeichner auf Proteinebene für SETDB1

histone-lysine N-methyltransferase SETDB1 , SET domain, bifurcated 1 , histone-lysine N-methyltransferase SETDB1-like , histone-lysine N-methyltransferase SETDB1-A , ERG-associated protein with SET domain , ERG-associated protein with a SET domain, ESET , H3-K9-HMTase 4 , histone H3-K9 methyltransferase 4 , histone-lysine N-methyltransferase, H3lysine-9 specific 4 , lysine N-methyltransferase 1E , tudor domain containing 21 , SET domain ERG-associated histone methyltransferase

GENE ID SPEZIES
689883 Rattus norvegicus
395847 Gallus gallus
469481 Pan troglodytes
716141 Macaca mulatta
100120014 Nasonia vitripennis
100138100 Bos taurus
100157920 Sus scrofa
100411734 Callithrix jacchus
100461671 Pongo abelii
100482250 Ailuropoda melanoleuca
553292 Danio rerio
9869 Homo sapiens
84505 Mus musculus
432147 Xenopus laevis
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