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SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. Zusätzlich bieten wir Ihnen SETDB1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SETDB1 Primary Antibody für ELISA, IHC - ABIN4353068
Schultz, Ayyanathan, Negorev, Maul, Rauscher: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. in Genes & development 2002
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Human Polyclonal SETDB1 Primary Antibody für ICC, IF - ABIN4353070
Ceol, Houvras, Jane-Valbuena, Bilodeau, Orlando, Battisti, Fritsch, Lin, Hollmann, Ferré, Bourque, Burke, Turner, Uong, Johnson, Beroukhim, Mermel, Loda, Ait-Si-Ali, Garraway, Young, Zon: The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. in Nature 2011
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Human Monoclonal SETDB1 Primary Antibody für ELISA, WB - ABIN967016
Rosendorff, Sakakibara, Lu, Kieff, Xuan, DiBacco, Shi, Shi, Gill: NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. in Proceedings of the National Academy of Sciences of the United States of America 2006
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Human Monoclonal SETDB1 Primary Antibody für ELISA, WB - ABIN969393
Gevaert, Staes, Van Damme, De Groot, Hugelier, Demol, Martens, Goethals, Vandekerckhove: Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. in Proteomics 2005
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Human Polyclonal SETDB1 Primary Antibody für IF (p), IHC (p) - ABIN1387645
Marco, Kisliouk, Tabachnik, Weller, Meiri et al.: DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on ... in Diabetes 2016
Human Polyclonal SETDB1 Primary Antibody für BP, ChIP - ABIN4353071
Skuland, Ovrevik, Låg, Schwarze, Refsnes: Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling. in Toxicology and applied pharmacology 2014
SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.
these data identify a critical functional role for ATF7IP (zeige ATF7IP Antikörper) in heterochromatin formation by regulating SETDB1 abundance in the nucleus.
SETDB1 triggers silencing of retrotransposons to inhibit the interferon (zeige IFNA Antikörper) response in acute myeloid leukemia (zeige BCL11A Antikörper) cells.
analysis of a 1q21.3 deletion encompassing SETDB1 that provides further support for the role of chromatin modifiers in the etiology of autism spectrum disorder
SETDB1 protein expression was significantly associated with poor survival and was related to TNM (zeige ODZ1 Antikörper) stage.
SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain. This ubiquitination is directly catalyzed by UBE2E family of E2 enzymes in an E3-independent manner while the conjugated-ubiquitin (Ub) is protected from active deubiquitination.
These results suggest that the ubiquitination of SETDB1 at lysine 867 controls the expression of its target gene by activating its H3K9 methyltransferase activity.
Authors observed several complementary mechanisms contributing to the upregulation of SETDB1 in HCC (zeige FAM126A Antikörper) cells. Besides copy number gains at the SETDB1 gene locus at chromosome 1q21 enhanced SETDB1 transcription mediated by the transcription factor SP1 (zeige SP1 Antikörper) could be detected.
BRCA1 and SETDB1 stand out as the most significant prognostic markers in this group of patients
These results suggest that SETDB1- mediated FosB (zeige FOSB Antikörper) expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy.
SETDB1 mutations are associated with malignant pleural mesotheliomas.
the SETDB1 repressor complex shields neuronal genomes from excess CTCF (zeige CTCF Antikörper) genome organizer binding and is critically required for structural maintenance of the protocadherin locus topologically associated domain
The results identify Setdb1 as a newly discovered meiotic and embryonic competence factor safeguarding genome integrity at the onset of life.
study identifed ESET as first trimethylated H3K9 histone methyltransferase playing a crucial role in T cell development
Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.
SETDB1 maintains silencing of intracisternal A particle, but in the absence of DNMT1 (zeige DNMT1 Antikörper), prolonged binding of NP95 (zeige UHRF1 Antikörper) to hemimethylated DNA transiently disrupts SETDB1-dependent H3K9me3 deposition.
Deletion of Setdb1 led to enlarged Meckel's cartilage. Chondrocytes from the Meckel's cartilage of Setdb1 mutant showed increased in size.
Setdb1 is a maternal-effect (zeige NLRP5 Antikörper) gene that controls meiotic progression and is essential for early embryogenesis. Setdb1 is an important regulator of Cdc14b (zeige CDC14B Antikörper).
The currently identified reciprocal action between SETDB1 and PRC2 reveals a novel mechanism underlying ES cell pluripotency and differentiation regulation.
regulates cancer cell growth via methylation of p53 (zeige TP53 Antikörper)
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
histone-lysine N-methyltransferase SETDB1
, SET domain, bifurcated 1
, histone-lysine N-methyltransferase SETDB1-like
, histone-lysine N-methyltransferase SETDB1-A
, ERG-associated protein with SET domain
, ERG-associated protein with a SET domain, ESET
, H3-K9-HMTase 4
, histone H3-K9 methyltransferase 4
, histone-lysine N-methyltransferase, H3lysine-9 specific 4
, lysine N-methyltransferase 1E
, tudor domain containing 21
, SET domain ERG-associated histone methyltransferase