SETDB1 Antikörper
Kurzübersicht für SETDB1 Antikörper (ABIN7253431)
Target
Alle SETDB1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Produktmerkmale
- Polyclonal Antibody
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Aufreinigung
- Antigen affinity purification
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Immunogen
- Fusion protein of human SETDB1
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Isotyp
- IgG
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anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibody
SETDB1 Reaktivität: Human WB, ELISA, IF Wirt: Maus Monoclonal 4A3 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibodySETDB1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) antibodySETDB1 Reaktivität: Human, Maus, Affe WB, ELISA, ICC Wirt: Maus Monoclonal 5H6A12 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibodySETDB1 Reaktivität: Human WB, IP, IF Wirt: Kaninchen Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225), (C-Term) antibodySETDB1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB5748 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225) antibodySETDB1 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibodySETDB1 Reaktivität: Human WB, ELISA Wirt: Maus Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1125-1175) antibodySETDB1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1050-1075) antibodySETDB1 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- IHC 1:50-1:300, ELISA 1:5000-1:10000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1.08 mg/mL
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Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- SETDB1 (SET Domain, Bifurcated 1 (SETDB1))
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Andere Bezeichnung
- SETDB1
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Hintergrund
- SETDB1,also named as ESET,KIAA0067 and KMT1E,belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation,gene silencing,and transcriptional repression. It has been identified as a target for treatment in Huntington Disease,given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.
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UniProt
- Q15047
Target
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