Retinoic Acid Early Transcript 1E Proteine (RAET1E)

RAET1E belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. Zusätzlich bieten wir Ihnen Retinoic Acid Early Transcript 1E Antikörper (136) und Retinoic Acid Early Transcript 1E Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RAET1E 135250 Q8TD07
RAET1E 379043 Q9CZQ6
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Showing 7 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$319.00
Details
Human Cells Human Fc Tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$275.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$382.86
Details

RAET1E Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu Retinoic Acid Early Transcript 1E (RAET1E) Interaktionspartnern

Human Retinoic Acid Early Transcript 1E (RAET1E) Interaktionspartner

  1. Blocking the interaction of NKG2D (zeige KLRK1 Proteine) with its ligands deleted the sensitizing effects of HCQ. In addition, we showed that HCQ did not affect the synthesis or degradation of ULBP4, but induced the translocation of ULBP4 from the cytoplasm to the cell membrane

  2. 5 of the 7 promoter polymorphisms of the RAET1E gene may disrupt transcription factor binding

  3. RAET1E promoter polymorphism has increased to nine types, and there are now 12 alleles determined by the coding exons, including one null.

  4. Patients whose tumors had high expression of RAET1E, ULBP1 and ULBP3 surviving a median of 11, 14 and 11 months, respectively, compared with disease-specific survival of 29, 30 and 25 months in patients whose tumors showed no expression of these ligands

  5. Binds the activating receptor NKG2D (zeige KLRK1 Proteine).

  6. immune escape mechanism of tumors via alternative splicing of ULBP RNA to generate a free soluble ULBP protein, RAET1E2, that may impair NKG2D (zeige KLRK1 Proteine)-mediated NK cell cytotoxicity to tumors

  7. All ULBP4 splice variants (ULBP4-I, ULBP4-II and ULBP4-III) were type 1 membrane-spanning molecules and had the ability to bind with human NKG2D (zeige KLRK1 Proteine) receptor in vitro

  8. data suggest that ULBP4 functions as a ligand for both TCRgammadelta and NKG2D (zeige KLRK1 Proteine) and may play a key role in immune surveillance of tumor development and clearance of viral infection

Mouse (Murine) Retinoic Acid Early Transcript 1E (RAET1E) Interaktionspartner

  1. CD4 (zeige CD4 Proteine)(+) NKG2D (zeige KLRK1 Proteine)(+) T cells induce NKG2D (zeige KLRK1 Proteine) down-regulation in natural killer cells in CD86 (zeige CD86 Proteine)-RAE-1epsilon transgenic mice.

  2. Reveal Raet1e, a major histocompatibility complex class 1-like molecule expressed in lesional aortic endothelial cells and macrophage-rich regions, as a novel atherosclerosis gene.

  3. Raet1e genes are directly transcriptionally activated by E2F (zeige E2F1 Proteine) family transcription factors, which play a central role in regulating cell cycle entry.

  4. RAE1 (zeige RAE1 Proteine) expression was sufficient to induce the recruitment of adoptively transferred CTLs to islets.

Retinoic Acid Early Transcript 1E (RAET1E) Protein Überblick

Protein Überblick

This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit RAET1E

  • retinoic acid early transcript 1E (RAET1E)
  • retinoic acid early transcript 1E (Raet1e)
  • bA350J20.7 Protein
  • LETAL Protein
  • N2DL-4 Protein
  • NKG2DL4 Protein
  • RAET1E2 Protein
  • RL-4 Protein
  • ULBP4 Protein

Bezeichner auf Proteinebene für RAET1E

NKG2D ligand 4 , RAE-1-like transcript 4 , lymphocyte effector toxicity activation ligand , RAE-1-epsilon , RAE1epsilon , Rae-1 epsilon , retinoic acid early-inducible protein 1-epsilon

GENE ID SPEZIES
135250 Homo sapiens
379043 Mus musculus
Ausgewählte Anbieter für Retinoic Acid Early Transcript 1E Proteine (RAET1E)
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