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The protein encoded by PCSK7 belongs to the subtilisin-like proprotein convertase family. Zusätzlich bieten wir Ihnen Proprotein Convertase Subtilisin/kexin Type 7 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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SPC7 is required for normal development of the eye and brain, possibly through processing BMPs, though other potential substrates cannot be excluded.
PCSK7 is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
Our present data suggest that PCSK7 as well as PCSK9 (zeige PCSK9 Antikörper) may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes.
PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis (zeige HFE Antikörper).
Furin (zeige FURIN Antikörper) and PC7 siRNAs induced HIF-1alpha (zeige HIF1A Antikörper) protein by increasing its translation, resulting in upregulation of VEGF-A (zeige VEGFA Antikörper).
The data suggest that PCSK7 genotypes may interact with dietary CHO (zeige COL11A1 Antikörper) intake on changes in insulin (zeige INS Antikörper) sensitivity in the white Americans.
Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis (zeige HFE Antikörper) patients homozygous for HFE (zeige HFE Antikörper) C282Y.
overexpression of PCs, furin (zeige FURIN Antikörper) and PC5 (zeige PCSK5 Antikörper), but not PC7, which are all expressed in SMC (zeige DYM Antikörper), increase PKGI (zeige PRKG1 Antikörper) cleavage in a dose-dependent manner
Among the PC family members, only furin (zeige FURIN Antikörper) activates hepcidin (zeige HAMP Antikörper) in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100
PCSK7 is involved in sTfR (zeige TFRC Antikörper) generation and iron homeostasis.
Proprotein convertase PC7 enhances the activation of the EGF receptor (zeige EGFR Antikörper) pathway through processing of the EGF (zeige EGF Antikörper) precursor.
PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.
PC7 has a critical role in normal processing of cholecystokinin (zeige CCK Antikörper) in mouse brain
PC7 and the related proteases Furin (zeige FURIN Antikörper) and Pace4 (zeige PCSK6 Antikörper) regulate E-cadherin (zeige CDH1 Antikörper) function during blastocyst formation.
Data show that BDNF (zeige BDNF Antikörper) and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF (zeige BDNF Antikörper) protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice.
in binding VEGFR-2 (zeige KDR Antikörper), furin (zeige FURIN Antikörper) and PC5 (zeige PCSK5 Antikörper) promote cleavage of N-and C-terminal VEGF-D (zeige Figf Antikörper) propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.
proprotein convertase PC7
, proprotein convertase subtilisin/kexin type 7
, proprotein convertase subtilisin/kexin type 7-like
, lymphoma proprotein convertase
, prohormone convertase 7
, prohormone convertase PC7
, proprotein convertase 7
, proprotein convertase 8
, subtilisin/kexin-like protease PC7
, subtilisin-like proprotein convertase 7