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The protein encoded by PRCP is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. Zusätzlich bieten wir Ihnen Prolylcarboxypeptidase Kits (41) und Prolylcarboxypeptidase Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.
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Data show that the KKN1 fragment generated by BMP1 (zeige BMP1 Antikörper)-cleavage of WFIKKN1 (zeige WFIKKN1 Antikörper) protein contributes most significantly to the observed enhancer activity.
For the first time, PRCP is identified as an apelin (zeige APLN Antikörper)-cleaving enzyme.
a previously unknown O-glycosylation site and Asn-hydroxylation site, indicating a novel feature of BMP-1 (zeige BMP1 Antikörper) in the EGF (zeige EGF Antikörper) domain. The study clearly outlines the benefit of in-depth characterization of overexpressed proteins to deduce important protein modifications.
BMP-1 (zeige BMP1 Antikörper) accelerates the connective tissue growth factor (zeige CTGF Antikörper) production dependently on cellular internalization in human dental pulp cells, indicating a novel property of BMP-1 (zeige BMP1 Antikörper) which potentially enhances bone-like reparative dentin formation.
Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways.
study thus highlights the severe and progressive nature of BMP1 (zeige BMP1 Antikörper)-associated OI in adults and broadens insights into the functional consequences of BMP1/mTLD-deficiency on ECM (zeige MMRN1 Antikörper) organization.
Data indicate that BMP-1 (zeige BMP1 Antikörper) can simultaneously trigger matrix assembly and boost the synthesis of matrix proteins via a direct effect on growth factors in the contexts of development, growth and tissue repair. [review]
The decrease in PRCP levels in the first 24 h after stroke onset is associated with stroke severity and an unfavourable short-term stroke outcome
Two novel variants in the BMP1 (zeige BMP1 Antikörper) gene: c.808A>G and c.1297G>T care associated with osteogenesis imperfecta (zeige COL1A2 Antikörper).
Frequent bone fracture in children is cause by BMP1 (zeige BMP1 Antikörper)-1 deficiency.
This study demonistrated that PRCP gene is broadly expressed in the brain.
PRCP regulates cell growth, angiogenesis, and the response to vascular injury
ACE2 (zeige ACE2 Antikörper) metabolizes ANG II (zeige AGT Antikörper) in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH.
PRCP is an important regulator of energy and glucose homeostasis since its deletion significantly improves metabolic parameters in mice exposed to both standard chow diet and high-fat diet
analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors
This study showed that PRCP mutant mice have a significant decrease in fat mass, although an increase in lean mass was also observed; reduced leptin (zeige LEP Antikörper) levels and increased energy expenditure were also found.
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.
PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels.
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
, mammalian tolloid protein
, procollagen C-endopeptidase
, procollagen C-proteinase
, lysosomal Pro-X carboxypeptidase
, proline carboxypeptidase
, angiotensinase C
, lysosomal carboxypeptidase C
, prolylcarboxypeptidase isoform 1 preproprotein