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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Zusätzlich bieten wir Ihnen KCNN2 Kits (6) und und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal KCNN2 Primary Antibody für IHC, WB - ABIN2776295
Morimoto, Ohya, Hayashi, Onozaki, Imaizumi: Cell-cycle-dependent regulation of Ca2+-activated K+ channel in Jurkat T-lymphocyte. in Journal of pharmacological sciences 2007
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Cow (Bovine) Polyclonal KCNN2 Primary Antibody für IHC, WB - ABIN2776144
Feranchak, Doctor, Troetsch, Brookman, Johnson, Fitz: Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels. in Gastroenterology 2004
Show all 2 Pubmed References
Study establishes the distribution profile of SK2 channel protein in human brain.The expression of SK2 human isoform b in brain could explain the variability of electrophysiological findings observed with SK2 channels.
These results provide new insights into the regulation of SK2 channel trafficking by the cytoskeletal proteins FLNA (zeige FLNA Antikörper) and alpha-actinin2, involving distinct recycling pathways
There was a significant association between the KCNN2 variants and clinically significant VTa. These findings suggest an association between KCNN2 and VTa; it also appears that KCNN2 variants may be adjunctive markers for risk stratification in patients susceptible to SCD (zeige SCD Antikörper).
The ER SK2 channel activation preserves ER Ca(2 (zeige CA2 Antikörper)+) uptake and retention which determines cell survival in conditions where sustained ER stress contributes to progressive neuronal death.
Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.
KCNN2 gene can have an important role in the development of coronary artery aneurysms in Kawasaki disease.
Increase in both Ca(2 (zeige CA2 Antikörper)+) sensitivity and SK2 protein expression contributes to the IKAS upregulation in failing human ventricles.
Decreased expression of small-conductance Ca2 (zeige CA2 Antikörper)+-activated K+ channels SK1 (zeige KCNN1 Antikörper) and SK2 in human chronic atrial fibrillation
RT-PCR analysis showed strong expression of SK2 mRNA in the normal human colon.
Because of the marked differential expression of SK2 channels in the heart, specific ligands for Ca2 (zeige CA2 Antikörper)+-activated K+ currents may offer a unique therapeutic opportunity to modify atrial cells without interfering with ventricular myocytes
SK2 (zeige PAPSS2 Antikörper) is nuclear in primary neurons and, unexpectedly, overexpressed SK2 (zeige PAPSS2 Antikörper) is neurotoxic in a dose-dependent manner.. We also found that SK2 (zeige PAPSS2 Antikörper) is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin (zeige HTT Antikörper)-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease (zeige HTT Antikörper)
Thus, MPP2 (zeige MPP2 Antikörper) is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2 (zeige PAPSS2 Antikörper)-containing channels.
Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias.
enhanced SK2 (zeige PAPSS2 Antikörper) channel control over NMDAR (zeige GRIN1 Antikörper) contributes to LTP (zeige SCP2 Antikörper) impairment via increased PP2A (zeige PPP2R2B Antikörper) activity following context dependent sensitization to morphine.
This study reveleated that outer hair cells of SK2 (zeige PAPSS2 Antikörper) knockout mice had few small efferent terminals. Synaptic cisterns were present, but smaller than those of wild-type littermates.
SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats
Mitochondrial small conductance SK2 (zeige PAPSS2 Antikörper) channels prevent glutamate (zeige GRIN1 Antikörper)-induced oxytosis and mitochondrial dysfunction.
Virtually all Cav2.1 (zeige CACNA1A Antikörper) clusters are colocalized in Purkinje cells with two types of calcium-activated potassium channels, SK2 (zeige PAPSS2 Antikörper) and BK.
A developmental increase and gradient in SK2 (zeige PAPSS2 Antikörper)-containing channel surface expression is found that underlie the influence on neurotransmission.
Sleep spindle occurrence is shaped by SK2 (zeige PAPSS2 Antikörper)-channel-mediated repetitive reticular thalamic nucleus neuron bursting & contributes to augmented NREMS consolidation & arousal threshold.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
, small conductance calcium-activated potassium channel protein 2
, small-conductance calcium-activated potassium channel
, apamin-sensitive small-conductance Ca2+-activated potassium channel
, small conductance potassium channel type 2
, SKCa 2
, small conductance calcium-activated potassium channel subfamily N member 2
, small conductance calcium-activated channel, subfamily N, member 2