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KCNN2 Antikörper (C-Term)

KCNN2 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Saccharomyces cerevisiae WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2776144
  • Target Alle KCNN2 Antikörper anzeigen
    KCNN2 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2))
    Bindungsspezifität
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 25
    • 14
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Saccharomyces cerevisiae
    Wirt
    • 15
    • 9
    • 1
    • 1
    Kaninchen
    Klonalität
    • 17
    • 9
    Polyklonal
    Konjugat
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser KCNN2 Antikörper ist unkonjugiert
    Applikation
    • 10
    • 8
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL NDQANTLVDL AKTQNIMYDM
    Homologie
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 100%, Zebrafish: 93%
    Produktmerkmale
    This is a rabbit polyclonal antibody against KCNN2. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN2
    Top Product
    Discover our top product KCNN2 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 579 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Chakroborty, Kim, Schneider, Jacobson, Molgó, Stutzmann: "Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 24, pp. 8341-53, (2012) (PubMed).

  • Target
    KCNN2 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2))
    Andere Bezeichnung
    KCNN2 (KCNN2 Produkte)
    Synonyme
    KCNN2 antikoerper, SK2 antikoerper, KCa2.2 antikoerper, SKCA2 antikoerper, SKCa 2 antikoerper, hSK2 antikoerper, fri antikoerper, potassium calcium-activated channel subfamily N member 2 antikoerper, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 antikoerper, KCNN2 antikoerper, Kcnn2 antikoerper
    Hintergrund
    Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN2 is a member of the KCNN family of potassium channel genes.
    Alias Symbols: SK2, hSK2, SKCA2, KCa2.2
    Protein Interaction Partner: SRPK2, SRPK1, UBC, ACTN2, KCNN2, CALM1,
    Protein Size: 579
    Molekulargewicht
    64 kDa
    Gen-ID
    3781
    NCBI Accession
    NM_021614, NP_067627
    UniProt
    Q9H2S1
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