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PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). Zusätzlich bieten wir Ihnen PCGF1 Antikörper (46) und PCGF1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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knockdown of PCGF1 results in reduced expression of DPPA4 (zeige DPPA4 Proteine) and other subunits of the variant PRC1 (zeige PRC1 Proteine) complex at both mRNA and protein levels. Thus, PCGF1 represents a physical and functional link between Polycomb (zeige CBX2 Proteine) function and pluripotency
polycomb (zeige CBX2 Proteine) has a role in stem cell fate and development of cancer (review)
Nspc1 has a positive role in maintaining the pluripotency of P19 (zeige CDKN2D Proteine) cells by directly regulating Oct4 (zeige POU5F1 Proteine).
Pcgf1 is an epigenetic regulator of hematopoietic cell differentiation. Simultaneous depletion of Runx1 (zeige RUNX1 Proteine) and Pcgf1 allows sustained self-renewal while blocking differentiation of lineage marker-negative cells in vitro.
Pcgf1 is involved in cell proliferation during early embryogenesis and establishes a link between epigenetics and aging.
Nspc1 was expressed globally at the early stage.
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001
polycomb group ring finger 1
, polycomb group RING finger protein 1
, RING finger protein 68
, nervous system Polycomb-1
, nervous system polycomb 1
, RING finger