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Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Zusätzlich bieten wir Ihnen OAZ1 Proteine (11) und OAZ1 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 30 products:
Human Polyclonal OAZ1 Primary Antibody für ICC, IF - ABIN4341277
Jakobsen, Vanselow, Skogs, Toyoda, Lundberg, Poser, Falkenby, Bennetzen, Westendorf, Nigg, Uhlen, Hyman, Andersen: Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. in The EMBO journal 2011
Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN).
Results show that ornithine decarboxylase antizyme 1 (OAZ1) simultaneously inhibits the proliferation and induces the differentiation of oral cancer cells.
To further understand its functions in CML (zeige BCR Antikörper) pathogenesis, OAZ1 was overexpressed, and PCR array analysis was used to monitor the expression of key genes commonly involved in leukemia development.
Gene expression studies have identified altered expression of ornithine decarboxylase antizyme 1 in suicide completers with a history of mood disorders.
In the absence of amino acids, mTORC1 is inhibited, whereas mTORC2 (zeige CRTC2 Antikörper) is activated, leading to the inhibition of global protein synthesis and increased AZ1 (zeige AZI1 Antikörper) synthesis via a cap-independent mechanism.
AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC (zeige ODC1 Antikörper) and AZI and inhibition of their function.
the differences in residues 125 and 140 in ODC and AZI are responsible for the differential antizyme-binding affinities
Data show that OAZ promotes the removal of Mps1 (zeige IDUA Antikörper) from centrosomes, and centrosome overproduction caused by reducing OAZ activity requires Mps1 (zeige IDUA Antikörper).
These data together demonstrate the existence of a c-Jun (zeige JUN Antikörper)-dependent mechanism regulating the abundance of the antiapoptotic DNp73 in response to genotoxic stress.
Human AZI is capable of acting as a general inhibitor for all members of the antizyme family.
Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).
we have generated transgenic mice overexpressing mouse antizyme 1 gene under its own regulatory sequences
Ornithine decarboxylase antizyme expression reduces tumor incidence, multiplicity and size even in the absence of p53 (zeige TP53 Antikörper).
The activity of AZ1 (zeige AZI1 Antikörper) was low in the virgin and involuting stages, but increased markedly during late pregnancy and early lactation.
Testosterone treatment enhanced AZ1 (zeige AZI1 Antikörper) and N1-SSAT (zeige SAT1 Antikörper) mRNA levels in a time-dependent manner
antizyme and glycosaminoglycans have roles in polyamine transport
OAZ can alter the intensity and duration of the BMP4 (zeige BMP4 Antikörper) stimulus through Smad6 (zeige SMAD6 Antikörper)
Az-1 (zeige AZI1 Antikörper) has a central and meaningful role in modulation of polyamine homeostasis, and in regulating cellular proliferation and transformation properties.
The data-driven docking results suggest that both proteins occupy the same binding site on Az1 (zeige AZI1 Antikörper), with Az1 (zeige AZI1 Antikörper) binding within a large groove in antizyme inhibitor (AzI (zeige AZI1 Antikörper)) and Ornithine Decarboxylase (ODC (zeige ODC1 Antikörper)).
antizyme expression requires programmed,+1 ribosomal frameshifting
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation.
, antizyme 1
, ODC antizyme
, ornithine decarboxylase antizyme 1