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MSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of MSR1. Zusätzlich bieten wir Ihnen Macrophage Scavenger Receptor 1 Antikörper (254) und Macrophage Scavenger Receptor 1 Kits (24) und viele weitere Produktgruppen zu diesem Protein an.
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SR-A1 suppresses lung cancer metastasis by downregulating SAA1 (zeige SAA1 Proteine) production in tumor-associated macrophages (TAM (zeige CCNA1 Proteine)).
PTX2 (zeige APCS Proteine) was identified PTX2 (zeige APCS Proteine) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
we found that higher percentages of circulating CD14 (zeige NDUFA2 Proteine)+CD204+, CD14 (zeige NDUFA2 Proteine)+CD163 (zeige CD163 Proteine)+CD204+ M2-like monocytes were significantly associated with TNM (zeige ODZ1 Proteine) stage, lymph node metastasis, and histological differentiation.
Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO (zeige MARCO Proteine).
The P275A Polymorphism in the Macrophage Scavenger Receptor 1 Gene is not associated with Prostate Cancer Risk.
Cyr61 (zeige CYR61 Proteine) promotes CD204 expression and the migration of macrophages via MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine) pathway in esophageal squamous cell carcinoma
miR (zeige MLXIP Proteine)-29a promotes scavenger receptor A expression by targeting QKI (zeige QKI Proteine) during monocyte-macrophage differentiation.
Heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Abeta (zeige APP Proteine) to SR-A, thereby promoting glial phagocytosis of Abeta (zeige APP Proteine) oligomer in microglia.
The truncating variant Arg293X in the gene encoding SRA (zeige SRA1 Proteine)-I/II was associated with reduced lung function and with increased risk of COPD (zeige ARCN1 Proteine) among men, as well as among alpha1-antitrypsin MZ and superoxide dismutase (zeige SOD1 Proteine)-3 E1I1 heterozygotes.
monomeric collagen type I via CD204 induces phospho-Akt (zeige AKT1 Proteine) expression shifting alveolar macrophages to the profibrotic M2 type. Innate immune responses induced by collagen monomers might perpetuate pulmonary fibrosis.
Data (including data from studies conducted in cells from knockout mice) suggest that signaling via Lpar1 (zeige LPAR1 Proteine), Cd14 (zeige CD14 Proteine), and Scara1 mediates uptake of oxidized LDL by macrophages leading to foam cell formation; lysophosphatidic acid (LPA) induces expression of Cd14 (zeige CD14 Proteine) and Scara1 in macrophages. (Lpar1 (zeige LPAR1 Proteine) = LPA receptor 1 (zeige LPAR1 Proteine); Cd14 (zeige CD14 Proteine) = monocyte differentiation antigen CD14 (zeige CD14 Proteine); Scara1 = scavenger receptor class A type I)
Common damage-associated molecular patterns (DAMPs) were internalized through the class A scavenger receptors MSR1 and MARCO (zeige MARCO Proteine) in vitro. In ischemic murine brain, DAMP (zeige AMPH Proteine) internalization was largely mediated by MSR1. Combined deficiency for Msr1 and Marco (zeige MARCO Proteine) in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke.
PTX2 (zeige PITX2 Proteine) was identified PTX2 (zeige PITX2 Proteine) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
this study shows that Msr1 functions as co-receptor along with TLRs for HMGB1 (zeige HMGB1 Proteine) in M1-type inflammatory macrophages
Our findings demonstrated that ClC-3 (zeige CLCN3 Proteine) deficiency inhibits atherosclerotic lesion development, possibly via suppression of JNK (zeige MAPK8 Proteine)/p38 MAPK (zeige MAPK14 Proteine) dependent SR-A expression and foam cell formation
FAP (zeige FAP Proteine)-cleaved collagen is a substrate for SR-A-dependent macrophage adhesion.
Macrophages regulate FX plasma levels in an SR-AI-dependent manner.
The results of this results reveal that SRA has important clinical implications for TLR-targeted immunotherapeutical strategy in intracerebral hemorrhage.
these findings suggest that SR-A-mediated dsRNA internalization is independent of innate antiviral signaling.
Our findings imply that SR-A may be an important target for improving therapeutic strategies for type 1 diabetes.
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
macrophage acetylated LDL receptor I and II
, macrophage scavenger receptor type III
, macrophage scavenger receptor types I and II
, scavenger receptor class A member 1
, scavenger receptor class A, member 1
, scavenger receptor type A
, macrophage scavenger receptor 1
, macrophage scavenger receptor type I
, macrophage scavenger receptor types I and II-like