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LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal LATS2 Primary Antibody für IP, PLA - ABIN152335
Kilili, Kyriakis et al.: Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 ... in The Journal of biological chemistry 2010
Show all 14 Pubmed References
Mouse (Murine) Polyclonal LATS2 Primary Antibody für WB - ABIN1881491
Oh, Lee, Kim, Kim, Oh, Hwang, Kong, Kwon, Lim: Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. in Molecular and cellular biology 2009
Show all 4 Pubmed References
The findings reveal a novel signal upstream of PRC2, and provide insight into the crucial role of LATS2 in coordinating the epigenome through regulation of PRC2.
Study demonstrates that, in 3 different murine syngeneic tumor models (B16, SCC7, and 4T1), loss of the Hippo pathway kinases LATS1 (zeige LATS1 Antikörper)/2 (large tumor suppressor (zeige LATS1 Antikörper) 1 and 2) in tumor cells inhibits tumor growth; data indicate a new paradigm for how tumor immunogenicity is regulated through the Hippo signaling pathway in tumor cells.
mice harboring liver-specific Lats2 conditional knockout (Lats2-CKO) displayed constitutive SREBP activation and overexpressed SREBP target genes and developed spontaneous fatty liver disease
protein and mRNA expression of the MST1 (zeige MST1 Antikörper) and LATS2 were decreased significantly as mouse age increased (p < 0.05), however, the mRNA expression of them increased significantly in 16 m compared with 5 m as well as the protein expression of LATS2.
Lats2 is recruited to the p53 (zeige TP53 Antikörper) pathway to coordinate proper transcriptional reprogramming.
Lats2 regulates the balance between proliferation and differentiation during adipose development.
miR (zeige MLXIP Antikörper)-302a plays a critical role in mediating the effects of folate on cell proliferation and cell cycle-specific apoptosis by targeting Lats2 gene.
KIBRA (zeige WWC1 Antikörper) associates with and activates Lats (large tumor suppressor (zeige LATS1 Antikörper)) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif
Lats2 plays an essential mitotic role in coordinating accurate cytokinesis completion, governing the stabilization of other mitotic regulators
Lats2 affects both growth and death of cardiac myocytes, but it primarily regulates the size of the heart and acts as an endogenous negative regulator of cardiac hypertrophy.
Upregulated long non-coding RNA AGAP2 (zeige AGAP2 Antikörper)-AS1 (zeige PTGDR Antikörper) represses LATS2 and KLF2 (zeige KLF2 Antikörper) expression through interacting with EZH2 (zeige EZH2 Antikörper) and LSD1 (zeige KDM1A Antikörper) in non-small-cell lung cancer cells.
Low LATS2 expression is associated with Liver Cancer.
The LATS2 is a prognostic biomarker and a tumour metastasis suppressor in hepatocellular carcinoma.
PVT1 recruits EZH2 (zeige EZH2 Antikörper) to the large tumor suppressor (zeige LATS1 Antikörper) kinase 2 (LATS2) promoter and represses LATS2 transcription.
findings reveal a non-canonical (that is, YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper)-independent) effect of LATS (zeige LATS1 Antikörper) in the regulation of human breast cell fate
LATS2 as the direct target of miR (zeige MLXIP Antikörper)-372 in prostate cancer cells.
Data suggest that, at least using the commercial antibodies used in this study, immunohistochemical staining for NF2 (neurofibromin 2 (zeige NF2 Antikörper)), LATS2 (large tumor suppressor (zeige LATS1 Antikörper) kinase 2), and YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) (nuclear translocation of complex of Yes-associated protein [YAP (zeige YAP1 Antikörper)] with transcriptional coactivator with PDZ-binding motif (zeige WWTR1 Antikörper) [TAZ (zeige TAZ Antikörper)]) is not helpful for differential diagnosis of mesothelioma versus a benign proliferation.
overexpression of LATS2 resulted in mobility inhibition in non-small cell lung cancer cell lines A549 and H1299, and reduced protein level of matrix metalloproteinase-2 (MMP-2 (zeige MMP2 Antikörper)) and MMP-9 (zeige MMP9 Antikörper).
LATS2 was found to have binding sites for miR (zeige MLXIP Antikörper)-135b in the 3'UTR (zeige UTS2R Antikörper) region and results demonstrated that LATS2 is a direct target of miR (zeige MLXIP Antikörper)-135b which regulates its expression in breast cancer cells.
Thus AMOT (zeige AMOT Antikörper) is a direct substrate of Lats1 (zeige LATS1 Antikörper)/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.
lats (zeige LATS1 Antikörper) genes show distinctly different expression profiles during gastrulation. lats1 (zeige LATS1 Antikörper) is almost ubiquitously expressed through development, and lats2 is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula.
The lats2 exhibit inverted expression to YAP1 (zeige YAP1 Antikörper), another member of the Hippo pathway which positively regulates cell growth and proliferation, during the differentiation of 3T3-L1 preadipocytes.
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
kinase phosphorylated during mitosis protein
, large tumor suppressor homolog 2
, serine/threonine-protein kinase LATS2
, serine/threonine-protein kinase kpm
, large tumor suppressor, homolog 2
, LATS (large tumor suppressor, Drosophila) homolog 2
, LATS, large tumor suppressor, homolog 2
, serine/threonine kinase KPM
, warts-like kinase
, large tumor suppressor 2-like protein