LATS2 Produkte
(LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
Kategorien
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
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Ausgewählte LATS2 Kategorien
LATS2 Antikörper
High quality antibodies with extensive validation data.
Empfohlene LATS2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro)
Validierungen
- (1)
- (2)
Kat. Nr.
ABIN753568
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC (p)
Validierungen
- (4)
- (2)
Kat. Nr.
ABIN1881491
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7268192
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene LATS2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968209
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene LATS2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123724
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
Kat. Nr.
ABIN5508985
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3093544
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren LATS2 Produkten
: "The polarity protein Angiomotin p130 controls dendritic spine maturation." in: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).: "Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence." in: Oncotarget, Vol. 9, Issue 2, pp. 2175-2192, (2018) (PubMed).
: "Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR ..." in: The Journal of biological chemistry, Vol. 291, Issue 34, pp. 17988-8005, (2016) (PubMed).
: "LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade." in: Oncogene, Vol. 34, Issue 1, pp. 73-83, (2015) (PubMed).
: "Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors." in: Molecular therapy. Nucleic acids, Vol. 4, pp. e246, (2015) (PubMed).
: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).
: "RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2." in: Nature cell biology, Vol. 16, Issue 10, pp. 962-71, 1-8, (2014) (PubMed).
: "The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl." in: Cell death and differentiation, Vol. 20, Issue 10, pp. 1330-40, (2013) (PubMed).
: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." in: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).
: "KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis." in: The Journal of biological chemistry, Vol. 287, Issue 41, pp. 34069-77, (2012) (PubMed).
Synonyme und alternative Namen zu LATS2
large tumor suppressor kinase 2 (LATS2), large tumor suppressor 2 (Lats2), large tumor suppressor kinase 2 (Lats2), large tumor suppressor kinase 2 (lats2), 4932411G09Rik, AV277261, AW228608, KPM, lats2Bezeichner auf Proteinebene für LATS2
- kinase phosphorylated during mitosis protein
- large tumor suppressor homolog 2
- serine/threonine-protein kinase LATS2
- serine/threonine-protein kinase kpm
- large tumor suppressor, homolog 2
- LATS (large tumor suppressor, Drosophila) homolog 2
- LATS, large tumor suppressor, homolog 2
- serine/threonine kinase KPM
- warts-like kinase
- large tumor suppressor 2-like protein
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