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Keratin 12 Proteine (KRT12)

KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Zusätzlich bieten wir Ihnen Keratin 12 Antikörper (44) und Keratin 12 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
KRT12 3859 Q99456
KRT12 268482  
KRT12 360625 Q6IFW5
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Showing 8 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_Wheat germ Human GST tag 25 μg Anmelden zum Anzeigen 7 bis 8 Tage
526,40 €
Details
Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.992,70 €
Details
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.015,40 €
Details
HOST_Escherichia coli (E. coli) Ratte His tag,S tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
731,43 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details
HOST_Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
923,21 €
Details

KRT12 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Keratin 12 (KRT12) Interaktionspartnern

Human Keratin 12 (KRT12) Interaktionspartner

  1. we show that the two PAX6 (zeige PAX6 Proteine) isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and keratin 12 (KRT12). PAX6 (zeige PAX6 Proteine) isoform-a induced KRT3 expression by targeting its upstream region. KLF4 (zeige KLF4 Proteine) enhanced this induction. A combination of PAX6 (zeige PAX6 Proteine) isoform-b, KLF4 (zeige KLF4 Proteine), and OCT4 (zeige POU5F1 Proteine) induced KRT12 expression

  2. Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals.

  3. We identified a novel missense mutation of the KRT12 gene in Meesmann corneal dystrophy. The in vivo confocal microscopy examinations revealed previously unreported depth-dependent ultrastructural changes in the living cornea.

  4. Exon sequencing of KRT3 and KRT12 in six affected and eight unaffected individuals did not detect any mutations or nucleotide sequence variants in Meesmann epithelial corneal dystrophy.

  5. The Leu132Pro missense mutation is within the helix-initiation motif of the keratin and is predicted to result in a significant structural change of the K12 protein.

  6. The lead siRNA, with an IC(50) of thirty picomolar, showed no keratin off-target effects or activation of TLR3 (zeige TLR3 Proteine) in the concentration ranges tested.

  7. Novel missense mutation within the highly conserved helix-initiation motif of KRT12 causing Meesmann's corneal dystrophy in a German family.

  8. Heterozygous Ala137Pro mutation in keratin 12 gene found in Japanese with Meesmann's corneal dystrophy.

  9. A novel missense mutation (Y429C) in KRT12 lead to MCD in 2 unrelated Taiwanese families.

  10. Mutation in the KRT12 gene is associated with Meesmann corneal dystrophy

Mouse (Murine) Keratin 12 (KRT12) Interaktionspartner

  1. clonal limbal stem cells randomly activate Krt12 alleles in the process of terminal differentiation in cornea

Keratin 12 (KRT12) Protein Überblick

Protein Überblick

KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy.

Genbezeichner und Symbole assoziert mit Keratin 12 Proteine (KRT12)

  • zgc:92533 (zgc:92533)
  • keratin 12 (KRT12)
  • keratin 12 (krt12)
  • keratin 12 (Krt12)
  • keratin K12 (LOC100009289)
  • AI835216 Protein
  • fb05e09 Protein
  • K12 Protein
  • Ka12 Protein
  • Krt-12 Protein
  • Krt1-12 Protein
  • wu:fa91b04 Protein
  • wu:fa97a07 Protein
  • wu:fb05e09 Protein
  • xk81b2 Protein

Bezeichner auf Proteinebene für Keratin 12 Proteine (KRT12)

keratin 12 , fa97a07 , krtt1c19a , cytokeratin , type I keratin , keratin 12 (Meesmann corneal dystrophy) , CK-12 , cytokeratin-12 , keratin, type I cytoskeletal 12 , keratin-12 , Keratin, type I cytoskeletal 12 (Cytokeratin 12) , keratin complex 1, acidic, gene 12 , K12 , keratin K12 , type I keratin KA12 , keratin, type I cytoskeletal 47 kDa , B2 keratin

GENE ID SPEZIES
445051 Danio rerio
100034663 Canis lupus familiaris
100144436 Xenopus (Silurana) tropicalis
468241 Pan troglodytes
3859 Homo sapiens
268482 Mus musculus
360625 Rattus norvegicus
398464 Xenopus laevis
100009289 Oryctolagus cuniculus
Ausgewählte Anbieter für Keratin 12 Proteine (KRT12)
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