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E2F6 encodes a member of the E2F transcription factor protein family. Zusätzlich bieten wir Ihnen E2F6 Proteine (3) und E2F6 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 81 products:
Human Polyclonal E2F6 Primary Antibody für ELISA, WB - ABIN4306784
McLaughlin-Drubin, Huh, Münger: Human papillomavirus type 16 E7 oncoprotein associates with E2F6. in Journal of virology 2008
Cow (Bovine) Polyclonal E2F6 Primary Antibody für IHC, WB - ABIN2779510
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 2 Pubmed References
E2F1 (zeige E2F1 Antikörper) forms a protein complex with EBNA3C and E2F6, and EBNA3C competes with E2F1 (zeige E2F1 Antikörper) for E2F6 binding. E2F6 is also recruited by EBNA3C to the E2F1 (zeige E2F1 Antikörper) promoter, which is critical for EBNA3C-mediated cell proliferation.
miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.
Analysis data from a panel of cell cycle transcription factors (E2F1, E2F4, E2F6, and GABPA) finds that a set of core cell cycle genes regulated in both U2OS and HeLa cells are bound by multiple cell cycle transcription factors.
After replication stress, the checkpoint kinase (zeige ATR Antikörper) Chk1 (zeige CHEK1 Antikörper) phosphorylates E2F6, leading to its dissociation from promoters. This promotes E2F (zeige E2F1 Antikörper)-dependent transcription, which mediates cell survival by preventing DNA damage and cell death
findings indicate an inhibitory role of E2F6 in the regulation of IL-13 (zeige IL13 Antikörper) and allergy
E2F6 may recruit BRG1 (zeige SMARCA4 Antikörper) in transcriptional regulation of genes important for G1/S phase transition of the cell cycle.
data suggest that E2F (zeige E2F1 Antikörper)- and Myc (zeige MYC Antikörper)-responsive genes are coregulated by E2F6 complex in quiescent cells
results suggest that E2F6 represses transcription of the brca1, ctip (zeige RBBP8 Antikörper), art27 (zeige UXT Antikörper), hp1alpha (zeige CBX5 Antikörper), and the rbap48 (zeige RBBP4 Antikörper) genes and depletion of E2F6 resulted in the recruitment of E2F1 (zeige E2F1 Antikörper) to the target promoters
contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins
E2F6 does not contain the domains required for modulation of squamous differentiation
These data reveal a novel interplay between the E2F pathway, beta2-adrenergic/PKA/PDE4D, and ERK/c-Src axis in fine tuning the pathological hypertrophic growth response.
E2f6 was similarly bound to the proximal promoter regions both in embryonic stem cells (ESCs (zeige NR2E3 Antikörper)) and epiblast stem cells (EpiSCs)
Data suggest that during development, E2F6 participates in the recruitment of polycomb (zeige CBX2 Antikörper) proteins to specific target promoters.
The 5' untranslated regions of E2F6 and E2F6b are unusually long, and they contain several upstream AUG codons followed by short reading frames. Our results suggest that translation of E2F6b is initiated by internal ribosome entry.
E2F6 is essential for the long-term somatic silencing of certain male-germ-cell-specific genes, but it is dispensable for cell-cycle regulation.
E2F6 silences SMC1beta (zeige SMC1B Antikörper) and STAG3 (zeige STAG3 Antikörper) in somatic cells
This analysis shows that E2f6 and Bmi1 (zeige BMI1 Antikörper) cooperate in the regulation of Hox (zeige MSH2 Antikörper) genes, and consequently axial skeleton development, but not in the repression of the Ink4a-Arf (zeige CDKN2A Antikörper) locus.
This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.
E2F transcription factor 6
, transcription factor E2F6
, E2F-binding site-modulating activity protein
, transcriptional repressor E2F6