E2F6 Antikörper (Middle Region)

Produktnummer ABIN2779510

Produktdetails anti-E2F6 Antikörper

Target: E2F6 (E2F Transcription Factor 6 (E2F6))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser E2F6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: HEQIVIAVKA PAETRLDVPA PREDSITVHI RSTNGPIDVY LCEVEQGQTS

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against E2F6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human E2F6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 129 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-E2F6 Antikörper (ABIN2779510)

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Details zu E2F6

Target: E2F6 (E2F Transcription Factor 6 (E2F6))

Andere Bezeichnung: E2F6 (E2F6 Produkte)

Synonyme: E2F-6 antikoerper, AI462434 antikoerper, E2F6b antikoerper, EMA antikoerper, E2F transcription factor 6 antikoerper, E2F6 antikoerper, E2f6 antikoerper

Hintergrund: E2F6 is a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants encoding several different isoforms have been found for this gene.
Protein Interaction Partner: TFDP2, TFDP1, KRTAP10-7, LYN, ARAF, APP, PCGF6, RYBP, YAF2, RNF2, SMARCAD1, UBC, L3MBTL2, EZH2, Epc1, EED, KMT2D, KMT2A, RING1, E2F1, BMI1, ZMYND8, ZMYND11, KDM5C, EZH1, CBX3, E2F6,
Protein Size: 129

Molekulargewicht: 14 kDa

Gen-ID: 1876

NCBI Accession: NM_212540, NP_997705

UniProt: Q6Q9Z5