anti-Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Antikörper

CFTR encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Zusätzlich bieten wir Ihnen CFTR Kits (34) und CFTR Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CFTR 1080 P13569
CFTR 12638 P26361
CFTR 24255 P34158
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Top anti-CFTR Antikörper auf antikoerper-online.de

Showing 10 out of 233 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert IHC (p) Formalin fixed paraffin embedded human pancreas stained with CFTR antibody ABIN115197 1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$841.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-CFTR antibody, Western blotting WB: Rat Pancreas Tissue Lysate Anti-CFTR antibody, IHC(P) IHC(P): Human Pancreatic Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$200.00
Details
Huhn Maus Unkonjugiert BP, FACS, ICC, IF, IHC, IHC (p), IP, Neut, WB Immunocytochemistry/Immunofluorescence: CFTR Antibody (CF3) [ABIN152670] - CFTR staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing CFTR at a dilution of 1:100-1:200 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated. Immunohistochemistry-Paraffin: CFTR Antibody (CF3) [ABIN152670] - Cancer biopsies of deparaffinized Human colon carcinoma tissue. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$447.56
Details
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of CFTR staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. w Western blot analysis of CFTR expression in SHSY5Y (A), NIH3T3 (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using CFTR (Ab-737) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CFTR (Ab-737) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB Western Blot (WB) analysis of specific cells using CFTR Polyclonal Antibody. 100 μL Anmelden zum Anzeigen 16 Days
$175.80
Details
Human Maus Unkonjugiert IHC (fro), IHC (p) Formalin fixed paraffin embedded human pancreas stained with CFTR antibody ABIN115197 0.5 mL Anmelden zum Anzeigen 6 bis 8 Tage
$522.50
Details
Human Kaninchen Unkonjugiert ICC, IF Figure 1 shows immunolocalization of CFTR in HEK293 cells stably transfected with the CFTR gene. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$447.56
Details
Human Maus Unkonjugiert IF, IHC (p), IP Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) 250 μL Anmelden zum Anzeigen 7 bis 9 Tage
$595.83
Details
Human Ziege Unkonjugiert IHC (p) AP23980PU-N ABCC7/CFTR antibody staining of Formalin-Fixed, Paraffin-Embedded Human Kidney. AP23980PU-N ABCC7/CFTR antibody staining of Formalin-Fixed, Paraffin-Embedded Human Prostate. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$500.50
Details

CFTR Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-CFTR Antikörper

  1. Chicken Monoclonal CFTR Primary Antibody für BP, FACS - ABIN152670 : Walker, Watson, Holmes, Edelman, Banting et al.: Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related ... in Journal of cell science 1995 (PubMed)
    Show all 9 Pubmed References

  2. Human Monoclonal CFTR Primary Antibody für IF, IHC (p) - ABIN5575335 : Riordan, Rommens, Kerem, Alon, Rozmahel, Grzelczak, Zielenski, Lok, Plavsic, Chou: Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. in Science (New York, N.Y.) 1989 (PubMed)

Weitere Antikörper gegen CFTR Interaktionspartner

Human Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. CFTR polymorphisms are genetic markers that are useful for identifying the mutant CFTR alleles in households of patients with cystic fibrosis (zeige S100A8 Antikörper) when it is not possible to establish the complete CFTR genotype. Moreover, the polymorphisms can be used for indirect CFTR mutation identification in cases of pre-fertilization, pre-implantation and prenatal analysis.

  2. The effect of complex alleles partially depends on the mutation in trans. Although larger studies are necessary, the CFTR activity on nasal epithelial cells is a rapid contributory tool to classify patients with CFTR dysfunction.

  3. Chloride anion behaves as a signaling effector for CFTR in the modulation of RPS27 (zeige RPS27 Antikörper) expression.

  4. Variations in CFTR gene is associated with cystic fibrosis (zeige S100A8 Antikörper).

  5. proteostasis regulator cysteamine, which rescues the function of the most common F508del-CFTR mutant and hence reduces lung inflammation in CF patients, can also repair the defects of CF macrophages, thus restoring both bacterial internalization and clearance through a process that involves upregulation of the pro-autophagic protein Beclin 1 (zeige BECN1 Antikörper) and re-establishment of the autophagic pathway.

  6. CFTR correctors are strong candidates for the treatment of Sjogren's syndrome and pancreatitis, since correcting ductal function is sufficient to rescue acinar cell function in salivary glands and pancreas.

  7. results suggest that cystic fibrosis transmembrane conductance regulator (CFTR) affects beta-cell function via a paracrine mechanism involving proinflammatory factors secreted from islet-associated exocrine-derived cell types

  8. Molecular dynamics of the cryo-EM CFTR structure

  9. This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway.

  10. report the interaction between CFTR and HDAC2 (zeige HDAC2 Antikörper), and its involvement in the development of Ph+ leukemia

Xenopus laevis Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. NDPK-A (zeige NME1 Antikörper) exists in a functional cellular complex with AMPK (zeige PRKAA2 Antikörper) and CFTR in airway epithelia, and NDPK-A (zeige NME1 Antikörper) catalytic function is required for the AMPK (zeige PRKAA2 Antikörper)-dependent regulation of CFTR

  2. Study conclude that when both CFTR and NPT2a are expressed in X. laevis oocytes, CFTR confers to NPT2a a cAMPi-dependent trafficking to the membrane.

  3. wild-type CFTR channel gating cycle is essentially irreversible and tightly coupled to the ATPase (zeige DNAH8 Antikörper) cycle, and that this coupling is completely destroyed by the NBD2 Walker B mutation D1370N but only partially disrupted by the NBD1 Walker A mutation K464A.

  4. The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that belongs to the superfamily of ATP binding cassette (ABC (zeige ABCB6 Antikörper)) transporters.

  5. These data suggest that the Xenopus P2Y1 receptor (zeige P2RY1 Antikörper) can increase both cyclic AMP (zeige TMPRSS5 Antikörper)/protein kinase A and calcium/protein kinase C (zeige PKC Antikörper) levels and that the PKC (zeige PKC Antikörper) pathway is involved in CFTR activation via potentiation of the PKA pathway.

Mouse (Murine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. a new and more convenient approach, based on in vivo imaging analysis, has been set up to evaluate the inflammatory response in the lung of CFTR-deficient (CF) mice, a murine model of cystic fibrosis (zeige S100A8 Antikörper).

  2. results reveal that by potentiating adenosine triphosphate-sensitive K+ (KATP) channel, cystic fibrosis transmembrane conductance regulator CFTR acts as a glucose-sensing negative regulator of glucagon (zeige GCG Antikörper) secretion in alpha cells

  3. This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway.

  4. CFTR is a tumor suppressor gene in murine and human colorectal cancer

  5. Insulin (zeige INS Antikörper) stimulation of Akt1 (zeige AKT1 Antikörper) and Akt2 (zeige AKT2 Antikörper) signaling in Cystic fibrosis (zeige S100A8 Antikörper) airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR.

  6. Biotinylation and streptavidin pull-down assays confirmed that CAL (zeige S100A11 Antikörper) dramatically reduces the expression level of total and cell surface Mrp2 (zeige ABCC2 Antikörper) in Huh-7 cells. Our findings suggest that CAL (zeige S100A11 Antikörper) interacts with Mrp2 (zeige ABCC2 Antikörper) and is a negative regulator of Mrp2 (zeige ABCC2 Antikörper) expression.

  7. Myelinosomes secreted from testis somatic TM4 (zeige TPM4 Antikörper) Sertoli cells provide the release of aggregate-prone mutant, but not normal Huntingtin (Htt (zeige HTT Antikörper)) exon1. Myelinosomes also support the release of other aggregate-prone mutant protein responsible for cystic fibrosis (zeige S100A8 Antikörper) (CF), F508delCFTR.

  8. ATP8B1 (zeige ATP8B1 Antikörper) is important for proper CFTR expression and function.

  9. Loss of cystic fibrosis (zeige S100A8 Antikörper) transmembrane regulator impairs intestinal oxalate secretion

  10. CFTR plays a role in suppressing MAPK (zeige MAPK1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper) to relieve inflammation, reduce proliferation and promote differentiation of keratinocytes, and thus promotes cutaneous wound healing.

Pig (Porcine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium.

  2. Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness.

  3. Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands.

  4. TGF-beta1 (zeige TGFB1 Antikörper), via TGF-beta1 (zeige TGFB1 Antikörper) receptor I and p38 MAPK (zeige MAPK14 Antikörper) signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.

  5. The esophageal submucosal glands (SMG (zeige SNRPG Antikörper)) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus.

  6. data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis (zeige S100A8 Antikörper) are likely primary

  7. The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR.

  8. CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation

  9. These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis (zeige S100A8 Antikörper) pigs, reveal some spared function in the DeltaF508 vs. null piglets.

  10. causal link between CFTR mutations and partial or total vas (zeige AVP Antikörper) deferens and/or epididymis atresia at birth

Cow (Bovine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I (zeige DNASE1 Antikörper) hypersensitive sites showed high homology in cow and pig.

Guinea Pig Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Results demonstrate functional coupling between Cftr and Slc26a6 (zeige SLC26A6 Antikörper)-like Cl(-)/HCO(3)(-) exchange activity in apical membrane of guinea pig pancreatic interlobular duct.

Zebrafish Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Molecular dynamics of the cryo-EM CFTR structure

  2. Study presents the structure of zebrafish CFTR in the phosphorylated, ATP-bound conformation, determined by cryoelectron microscopy to 3.4 A resolution. Comparison of the two conformations shows major structural rearrangements leading to channel opening.

  3. Study determined the structure of the zebrafish CFTR by electron cryo-microscopy to 3.7 A resolution; shares 55% sequence identity with human CFTR, and 42 of the 46 cystic-fibrosis (zeige S100A8 Antikörper)-causing missense mutational sites are identical.

  4. Cftr mutant zebrafish develops pancreatic destruction similar to cystic fibrosis (zeige S100A8 Antikörper) of the human pancreas.

CFTR Antigen-Profil

Protein Überblick

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.

Genbezeichner und Symbole assoziert mit CFTR

  • cystic fibrosis transmembrane conductance regulator (CFTR) Antikörper
  • cystic fibrosis transmembrane conductance regulator (cftr-A) Antikörper
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR) Antikörper
  • cystic fibrosis transmembrane conductance regulator (Cftr) Antikörper
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (cftr) Antikörper
  • abc35 Antikörper
  • abcc7 Antikörper
  • AW495489 Antikörper
  • CF Antikörper
  • CFTR Antikörper
  • cftr/mrp Antikörper
  • dJ760C5.1 Antikörper
  • mrp7 Antikörper
  • RGD1561193 Antikörper
  • si:dkey-270i2.2 Antikörper
  • tnr-cftr Antikörper
  • xcftr Antikörper

Bezeichner auf Proteinebene für CFTR

cAMP-dependent chloride channel , channel conductance-controlling ATPase , cystic fibrosis transmembrane conductance regulator , cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) , cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) , ATP-binding cassette sub-family C member 7 , ATP-binding cassette transporter sub-family C member 7 , ATP-binding cassette, subfamily c, member 7 , cystic fibrosis transmembrane conductance regulator homolog , cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7 , CFTR chloride channel , chloride channel , CFTR cAMP-dependent chloride channel protein , Channel conductance-controlling ATPase , abcc7

GENE ID SPEZIES
1080 Homo sapiens
373725 Xenopus laevis
780954 Monodelphis domestica
100137161 Nomascus leucogenys
12638 Mus musculus
24255 Rattus norvegicus
100049619 Gallus gallus
492302 Canis lupus familiaris
100071259 Equus caballus
403154 Sus scrofa
281067 Bos taurus
443347 Ovis aries
100009471 Oryctolagus cuniculus
463674 Pan troglodytes
100137035 Pongo abelii
100719898 Cavia porcellus
100381094 Xenopus laevis
100126675 Papio anubis
559080 Danio rerio
Ausgewählte Anbieter für anti-CFTR (CFTR) Antikörper
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