anti-Claspin (CLSPN) Antikörper

The product of CLSPN is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. Zusätzlich bieten wir Ihnen Claspin Kits (2) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CLSPN 298534  
CLSPN 63967 Q9HAW4
CLSPN 269582 Q80YR7
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Top anti-Claspin Antikörper auf antikoerper-online.de

Showing 10 out of 18 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, PLA, WB Detection of human Claspin by Western blot and Immunoprecipitation.  Samples: HeLa Whole cell lysates (20 mcg/lane for WB, 1 mg for IP) Antibody:  ABIN151714 used at the dilution shown for WB (A) and at  1 mcg/ml of lysate for IP and 0.2 mcg/ml for WB (B).  Detection: Chemiluminescence with exposure time of 25 sec. Immunoprecipitation: Claspin Antibody [ABIN151714] - Whole cell lysate (1 mg for IP; 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Claspin antibody used for IP at 6 ug/mg lysate. For blotting immunoprecipitated Claspin,was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details
Human Kaninchen Unkonjugiert WB Western Blot: Claspin Antibody [ABIN4298859] - Whole cell lysate (20 ug) from HeLa cells. Antibody used at 1 or 0.5 ug/ml with (+) or without (-) blocking peptide. Western Blot: Claspin Antibody  - Detection of Human Claspin by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Claspin antibody  used for WB at 0.2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details
Human Kaninchen Unkonjugiert IP, WB Western Blot: Claspin Antibody [ABIN151715] - Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Affinity purified rabbit anti-Claspin antibody ABIN151715 (lot number 2) used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. Claspin was also immunoprecipitated by a previous lot (lot number 1) of this antibody. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B). 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ICC, IF Immunocytochemistry/Immunofluorescence: Claspin Antibody  - Staining of human cell line U-251 MG shows localization to nucleoplasm & the Golgi apparatus. 100 μL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
Details
Human Kaninchen Unkonjugiert IP, WB   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$815.83
Details
Human Kaninchen Unkonjugiert IP, WB   100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$245.00
Details
Human Kaninchen Unkonjugiert IP, WB   100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$551.57
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$157.06
Details
Human Kaninchen Unkonjugiert IF, IP, IHC (p), PLA, WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$595.83
Details

CLSPN Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Rat (Rattus)


Human ,


Mouse (Murine)


Am meisten referenzierte anti-Claspin Antikörper

  1. Human Polyclonal Claspin Primary Antibody für ICC, IF - ABIN151714 : Li, Elder, Qin, Park, Liang, Zhao: Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1. in The Journal of biological chemistry 2007 (PubMed)
    Show all 12 Pubmed References

  2. Human Polyclonal Claspin Primary Antibody für WB - ABIN4298859 : Jiang, Pereira, Maxfield, Russell, Goudelock, Sanchez: Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal Claspin Primary Antibody für IP, WB - ABIN151715 : Gao, Inuzuka, Korenjak, Tseng, Wu, Wan, Kirschner, Dyson, Wei: Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. in Molecular biology of the cell 2009 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen Claspin Interaktionspartner

Human Claspin (CLSPN) Interaktionspartner

  1. The functions of claspin are discussed and how its deregulation may contribute to cancer initiation and progression. [REVIEW]

  2. Results unveil a new aspect of PERK (zeige EIF2AK3 Antikörper) function and previously unknown roles for Claspin and Chk1 (zeige CHEK1 Antikörper) as negative regulators of DNA replication in the absence of genotoxic stress.

  3. found that USP9X (zeige USP9X Antikörper) regulated the expression and stability of CLASPIN in an S-phase-specific manner. USP9X (zeige USP9X Antikörper) depletion profoundly impairs the progression of DNA replication forks, causing unscheduled termination events with a frequency similar to CLASPIN depletion, resulting in excessive endogenous DNA damage

  4. Functional analyses indicat that the expression TopBP1 (zeige TOPBP1 Antikörper) and Claspin positively affects the survival of brain cancer cells after exposure to radiation.

  5. And-1 coordinates with Claspin for efficient Chk1 (zeige CHEK1 Antikörper) activation in response to replication stress.

  6. USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro.

  7. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.

  8. findings identify claspin as an in vivo substrate for the BRCA1 E3 ligase and suggest that its modification selectively triggers CHK1 (zeige CHEK1 Antikörper) activation for the homology-directed repair of a subset of genotoxic lesions

  9. analysis of claspin expression could be clinically relevant in the diagnosis of HPV-related cervical lesions, in particular when applied to cervico-vaginal cytology

  10. The conserved C terminus of Claspin interacts with Rad9 (zeige RAD9A Antikörper) and ensures timely activation of the ATR (zeige ANTXR1 Antikörper)-Chk1 (zeige CHEK1 Antikörper) pathway.

Mouse (Murine) Claspin (CLSPN) Interaktionspartner

  1. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1 (zeige TOPBP1 Antikörper)) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR (zeige ATR Antikörper)) phosphorylation of checkpoint kinase 1 (Chk1 (zeige CHEK1 Antikörper)).

  2. Rad9A (zeige RAD9A Antikörper)-mediated Claspin localization is a vital step during checkpoint activation.

Xenopus laevis Claspin (CLSPN) Interaktionspartner

  1. Claspin localizes to mitotic centromeres depending on mitotic SUMOylation.

  2. Claspin is phosphorylated at the midblastula transition at both DNA replication checkpoint-dependent and -independent sites.

  3. recent findings and mechanisms of checkpoint regulation by claspin

  4. the interaction of DDK with Claspin mediates a checkpoint-independent function of Claspin related to DNA replication.

  5. Claspin has roles in the Chk1 (zeige CHEK1 Antikörper) pathway and functions in checkpoint control [review]

  6. our findings suggest that only transient interaction of Claspin with replication forks potentiates its Chk1 (zeige CHEK1 Antikörper)-activating function. Also, stable binding of Claspin to chromatin may play a role in other functions besides the activation of Chk1 (zeige CHEK1 Antikörper).

Claspin (CLSPN) Antigen-Profil

Protein Überblick

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit anti-Claspin (CLSPN) Antikörper

  • claspin (Clspn) Antikörper
  • claspin (CLSPN) Antikörper
  • claspin (clspn) Antikörper
  • claspin S homeolog (clspn.S) Antikörper
  • B130025E01 Antikörper
  • C85083 Antikörper
  • CLSPN Antikörper
  • E130314M08Rik Antikörper
  • xClaspin Antikörper

Bezeichner auf Proteinebene für anti-Claspin (CLSPN) Antikörper

claspin homolog (Xenopus laevis) , claspin , claspin homolog , hClaspin , xClaspin

GENE ID SPEZIES
298534 Rattus norvegicus
100055244 Equus caballus
456746 Pan troglodytes
100124314 Xenopus (Silurana) tropicalis
100347850 Oryctolagus cuniculus
100482920 Ailuropoda melanoleuca
100525928 Sus scrofa
100543387 Meleagris gallopavo
100567034 Anolis carolinensis
100597024 Nomascus leucogenys
63967 Homo sapiens
269582 Mus musculus
398192 Xenopus laevis
Ausgewählte Anbieter für anti-Claspin (CLSPN) Antikörper
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