Claspin Antikörper (AA 725-775)
-
- Target Alle Claspin (CLSPN) Antikörper anzeigen
- Claspin (CLSPN)
-
Bindungsspezifität
- AA 725-775
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser Claspin Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
- Verwendungszweck
- Rabbit anti-Claspin Antibody, Affinity Purified
- Homologie
- Orangutan,Gorilla,Chimpanzee
- Aufreinigung
- Affinity Purified
- Immunogen
- between AA 725 and 775
- Isotyp
- IgG
- Top Product
- Discover our top product CLSPN Primärantikörper
-
anti-Claspin (CLSPN) (N-Term) antibody
CLSPN Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Claspin (CLSPN) (AA 650-750) antibodyCLSPN Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
-
- Applikationshinweise
-
IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 1 - 5 μg/mg lysate
WB: 1:500 - 1:2,500
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Haltbarkeit
- 12 months
-
- Target
- Claspin (CLSPN)
- Andere Bezeichnung
- Claspin (CLSPN Produkte)
- Synonyme
- CLSPN antikoerper, xClaspin antikoerper, B130025E01 antikoerper, C85083 antikoerper, E130314M08Rik antikoerper, claspin antikoerper, claspin S homeolog antikoerper, Clspn antikoerper, CLSPN antikoerper, clspn antikoerper, clspn.S antikoerper
- Hintergrund
- Background: Claspin is a checkpoint protein that interacts with and regulates checkpoint kinase 1 (Chk1) in response to replication stress. The interaction between claspin and Chk1 has been demonstrated to be required for ATR-dependent Chk1 activation. The interaction involves the phosphorylation of claspin that may be accomplished by Chk1 kinase activity. Claspin has been found to localize to chromatin in both the presence and absence of damaged DNA and to associate with PCNA, as an essential component of the DNA replication machinery. This association with the replication machinery may indicate a role for claspin in linking replication to DNA damage signaling and Chk1 activation.
- Gen-ID
- 63967
- UniProt
- Q9HAW4
-
