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CERS1 encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Zusätzlich bieten wir Ihnen Ceramide Synthase 1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CERS1 Primary Antibody für ELISA, WB - ABIN564667
Senkal, Ponnusamy, Rossi, Bialewski, Sinha, Jiang, Jazwinski, Hannun, Ogretmen: Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. in Molecular cancer therapeutics 2007
Show all 5 Pubmed References
Human Polyclonal CERS1 Primary Antibody für ELISA, WB - ABIN451734
Venkataraman, Riebeling, Bodennec, Riezman, Allegood, Sullards, Merrill, Futerman et al.: Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a ... in The Journal of biological chemistry 2002
This study highlights a close interaction between CLN5 (zeige CLN5 Antikörper)/CLN8 (zeige CLN8 Antikörper) proteins, and their role in sphingolipid metabolism. Our findings suggest that CLN5p/CLN8p most likely are positive modulators of CerS1 and/or CerS2 (zeige CERS2 Antikörper).
Moreover, an alternatively spliced variant CerS1 mRNA (CerS1-2) was detected mainly in cancer cells or primary tumour tissues compared to controls, which was targeted by miR (zeige MLXIP Antikörper)-574-5p for degradation
The variation in LASS1 is functional, causing enhanced expression of the gene, and it contributes to healthy aging and greater survival in the tenth decade of life.
The study suggests that diverse stresses initiate responses through different signaling pathways, which ultimately converge to regulate CerS1 localization.
regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cel
LAG1 (zeige CCL4 Antikörper) and C18 (zeige BBS9 Antikörper)-ceramide have roles in the regulation of growth of HNSCC
The strong association of LCB (zeige CLTB Antikörper) levels with neuronal survival both in vivo and in vitro suggests high-level accumulation of LCBs is a possible underlying cause of the CerS1 deficiency-induced neuronal death.
CerS1, -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (zeige SIRT3 Antikörper)-null mice.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6 (zeige CERS6 Antikörper)) activity in macrophages is responsible for the accumulation of ceramide.
an essential function of CerS1-derived ceramide in the regulation of cerebellar development and neurodevelopmentally regulated behavior.
Findings indicate that AtORM1 and AtORM2 mediation of serine palmitoyltransferase (SPT) activity differentially regulates functionally distinct ceramide synthase activities as part of a broader sphingolipid homeostatic regulatory network.
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1.
longevity assurance gene 1
, longevity assurance (LAG1, S. cerevisiae) homolog 1
, longevity assurance gene 1 protein homolog 1
, protein UOG-1
, upstream of GDF1
, LAG1 homolog, ceramide synthase 1
, LAG1 longevity assurance homolog 1
, longevity assurance homolog 1
, longevity assurance-like protein 1