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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Zusätzlich bieten wir Ihnen PD-L1 Antikörper (402) und PD-L1 Kits (52) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) PD-L1 Protein expressed in Human Cells - ABIN2007141
Trabattoni, Saresella, Biasin, Boasso, Piacentini, Ferrante, Dong, Maserati, Shearer, Chen, Clerici: B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. in Blood 2003
Show all 5 Pubmed References
It was concluded that down-regulated expression of miR (zeige MLXIP Proteine)-143 and up-regulation of its direct target B7H1 may indicate a novel therapeutic method for radiation-induced thymic lymphoma by increased expression of miR (zeige MLXIP Proteine)-143 or inhibition of B7H1.
HDAC6 (zeige HDAC6 Proteine) inhibition reduces tumor growth and PD-L1 production in vivo.
findings indicate that the PerC B cells, including PD-L1/PD-L2 (zeige PDCD1LG2 Proteine) B-1a cells, may suppress T cells responding to allostimulation, and thus may be optimal for donor lymphocyte injection
PD-L1 selectively enhances T cell-mediated immune responses, driving graft-versus-host disease lethality and suggesting a context-dependent function of the PD-1 (zeige PDCD1 Proteine)/PD-L1 axis
Mesenteric lymph node CD11b (zeige ITGAM Proteine)(-) CD103 (zeige ITGAE Proteine)(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta (zeige TGFB1 Proteine) activation.
These results indicate that the outcome of PD-L1-mediated signaling in CD8 (zeige CD8A Proteine)+ T cells depends on the presence or absence of CD4 (zeige CD4 Proteine)+ T cells, the nature of the interacting receptor expressed by CD8 (zeige CD8A Proteine)+ T cells, and the tissue environment in which the signaling occurs.
CD169 (zeige SIGLEC1 Proteine)(+) macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8 (zeige CD8A Proteine)(+) T-cell exhaustion and immunopathology.
findings identify a previously unrecognized role of PD-L1 as an endogenous pain inhibitor and a neuromodulator.
reduced cytotoxicity as a key mechanism by which tumor PD-L1 suppresses antitumor immunity and demonstrate that tumor PD-L1 is not just a marker of suppressed antitumor immunity.
Apigenin inhibits IFN-gamma-induced (zeige SAMHD1 Proteine) PD-L1 expression by breast cancer cells, potentially rendering BC cells that lack constitutive PD-L1 expression more susceptible to T cellmediated anti-tumor immune responses.
PD-L1 overexpression altered the expression of many epithelial to mesenchymal transition marker genes like E-cadherin (zeige CDH1 Proteine), N-cadherin (zeige CDH2 Proteine), Zeb-1 and Vimentin (zeige VIM Proteine), which was consistent with epithelial to mesenchymal transition promotion.
High PD-L1 expression is associated with Small Cell Lung Cancer.
Data suggest that expression of tumor biomarker CD274 in both tumor cells and tumor-infiltrating immune cells correlates with subsets of NSCLC; high expression of CD274 in lung adenocarcinoma subsets correlates with high histologic grade and solid subtype; high expression of CD274 in subsets also correlates with high smoking pack-years. (NSCLC = non-small-cell lung carcinoma)
PD-L1 protein expression was significantly higher in smoking-associated adenocarcinoma and in EGFR (zeige EGFR Proteine) mutation-negative adenocarcinoma. PD-L1 protein expression was associated with poor survival in patients with lung adenocarcinoma.
Low PD-L1 expression is associated with pediatric solid tumors.
Increased BAG-1 (zeige BAG1 Proteine) by PD-L1 confers resistance to tyrosine kinase (zeige TXK Proteine) inhibitor in non-small cell lung cancer via persistent activation of ERK (zeige EPHB2 Proteine) signaling.
PD-L1 expression is an important prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent surgical resection.
PD-L1 detection in cancer cells and immune cells varied by antibody clone.
A meta-analysis indicates that circulating sPD (zeige HOXD13 Proteine)-L1 changes may serve as a useful biomarker for cancer prognosis, and higher level of sPD (zeige HOXD13 Proteine)-L1 may also be associated with poor outcomes in patients with cancer. Review.
Expression of PD-L1 in Hodgkin Lymphoma patients is positively correlated with microvessel density.
These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (zeige PDCD1 Proteine)/PD-L1 pathway.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (zeige PDCD1LG2 Proteine) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1