CD274 Molecule Proteine (CD274)

Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Zusätzlich bieten wir Ihnen PD-L1 Antikörper (402) und PD-L1 Kits (52) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CD274 60533 Q9EP73
CD274 29126 Q9NZQ7
CD274 499342  
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Top PD-L1 Proteine auf antikoerper-online.de

Showing 10 out of 83 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
Details
HEK-293 Cells Human His tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$615.00
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
Details
HEK-293 Cells Maus His tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$615.00
Details
Human Cells Maus Fc Tag,His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Human Cells Human His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
HEK-293 Cells Human His tag Human PD-L1, His Tag (HPLC-verified) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%. Immobilized Human PD-L1, His Tag (HPLC-verified)  with a linear range of 0.05-1 μg/mL. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
Details
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details

CD274 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) , , , , , ,
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Human , , , , , , , , , , ,
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Rat (Rattus) ,
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Am meisten referenzierte PD-L1 Proteine

  1. Mouse (Murine) PD-L1 Protein expressed in Human Cells - ABIN2007141 : Trabattoni, Saresella, Biasin, Boasso, Piacentini, Ferrante, Dong, Maserati, Shearer, Chen, Clerici: B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. in Blood 2003 (PubMed)
    Show all 5 Pubmed References

Weitere Proteine zu CD274 Molecule (CD274) Interaktionspartnern

Mouse (Murine) CD274 Molecule (CD274) Interaktionspartner

  1. It was concluded that down-regulated expression of miR (zeige MLXIP Proteine)-143 and up-regulation of its direct target B7H1 may indicate a novel therapeutic method for radiation-induced thymic lymphoma by increased expression of miR (zeige MLXIP Proteine)-143 or inhibition of B7H1.

  2. HDAC6 (zeige HDAC6 Proteine) inhibition reduces tumor growth and PD-L1 production in vivo.

  3. findings indicate that the PerC B cells, including PD-L1/PD-L2 (zeige PDCD1LG2 Proteine) B-1a cells, may suppress T cells responding to allostimulation, and thus may be optimal for donor lymphocyte injection

  4. PD-L1 selectively enhances T cell-mediated immune responses, driving graft-versus-host disease lethality and suggesting a context-dependent function of the PD-1 (zeige PDCD1 Proteine)/PD-L1 axis

  5. Mesenteric lymph node CD11b (zeige ITGAM Proteine)(-) CD103 (zeige ITGAE Proteine)(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta (zeige TGFB1 Proteine) activation.

  6. These results indicate that the outcome of PD-L1-mediated signaling in CD8 (zeige CD8A Proteine)+ T cells depends on the presence or absence of CD4 (zeige CD4 Proteine)+ T cells, the nature of the interacting receptor expressed by CD8 (zeige CD8A Proteine)+ T cells, and the tissue environment in which the signaling occurs.

  7. CD169 (zeige SIGLEC1 Proteine)(+) macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8 (zeige CD8A Proteine)(+) T-cell exhaustion and immunopathology.

  8. findings identify a previously unrecognized role of PD-L1 as an endogenous pain inhibitor and a neuromodulator.

  9. reduced cytotoxicity as a key mechanism by which tumor PD-L1 suppresses antitumor immunity and demonstrate that tumor PD-L1 is not just a marker of suppressed antitumor immunity.

  10. Apigenin inhibits IFN-gamma-induced (zeige SAMHD1 Proteine) PD-L1 expression by breast cancer cells, potentially rendering BC cells that lack constitutive PD-L1 expression more susceptible to T cellmediated anti-tumor immune responses.

Human CD274 Molecule (CD274) Interaktionspartner

  1. PD-L1 overexpression altered the expression of many epithelial to mesenchymal transition marker genes like E-cadherin (zeige CDH1 Proteine), N-cadherin (zeige CDH2 Proteine), Zeb-1 and Vimentin (zeige VIM Proteine), which was consistent with epithelial to mesenchymal transition promotion.

  2. High PD-L1 expression is associated with Small Cell Lung Cancer.

  3. Data suggest that expression of tumor biomarker CD274 in both tumor cells and tumor-infiltrating immune cells correlates with subsets of NSCLC; high expression of CD274 in lung adenocarcinoma subsets correlates with high histologic grade and solid subtype; high expression of CD274 in subsets also correlates with high smoking pack-years. (NSCLC = non-small-cell lung carcinoma)

  4. PD-L1 protein expression was significantly higher in smoking-associated adenocarcinoma and in EGFR (zeige EGFR Proteine) mutation-negative adenocarcinoma. PD-L1 protein expression was associated with poor survival in patients with lung adenocarcinoma.

  5. Low PD-L1 expression is associated with pediatric solid tumors.

  6. Increased BAG-1 (zeige BAG1 Proteine) by PD-L1 confers resistance to tyrosine kinase (zeige TXK Proteine) inhibitor in non-small cell lung cancer via persistent activation of ERK (zeige EPHB2 Proteine) signaling.

  7. PD-L1 expression is an important prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent surgical resection.

  8. PD-L1 detection in cancer cells and immune cells varied by antibody clone.

  9. A meta-analysis indicates that circulating sPD (zeige HOXD13 Proteine)-L1 changes may serve as a useful biomarker for cancer prognosis, and higher level of sPD (zeige HOXD13 Proteine)-L1 may also be associated with poor outcomes in patients with cancer. Review.

  10. Expression of PD-L1 in Hodgkin Lymphoma patients is positively correlated with microvessel density.

Pig (Porcine) CD274 Molecule (CD274) Interaktionspartner

  1. These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (zeige PDCD1 Proteine)/PD-L1 pathway.

  2. role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development

  3. These data suggest that overexpression of PD-L1 and PD-L2 (zeige PDCD1LG2 Proteine) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.

  4. Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.

  5. A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.

Cow (Bovine) CD274 Molecule (CD274) Interaktionspartner

  1. This study provides novel information for the understanding of signalling through PD-L1.

PD-L1 (CD274) Protein Überblick

Protein Überblick

Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Genbezeichner und Symbole assoziert mit CD274 Molecule Proteine (CD274)

  • CD274 molecule (CD274)
  • CD274 antigen (Cd274)
  • CD274 molecule (Cd274)
  • programmed cell death 1 ligand 2 (PDCD1LG2)
  • A530045L16Rik Protein
  • B7-H Protein
  • B7H1 Protein
  • PD-L1 Protein
  • PDCD1L1 Protein
  • PDCD1LG1 Protein
  • PDL1 Protein
  • RGD1566211 Protein

Bezeichner auf Proteinebene für CD274 Molecule Proteine (CD274)

CD274 molecule , CD274 antigen , programmed cell death 1 ligand 1 , programmed cell death ligand 1 , B7 homolog 1 , PDCD1 ligand 1 , programmed death ligand 1

GENE ID SPEZIES
427224 Gallus gallus
464981 Pan troglodytes
716043 Macaca mulatta
100126721 Papio anubis
100357106 Oryctolagus cuniculus
60533 Mus musculus
29126 Homo sapiens
499342 Rattus norvegicus
100722088 Cavia porcellus
574058 Sus scrofa
484186 Canis lupus familiaris
533834 Bos taurus
427225 Gallus gallus
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