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BUB1 encodes a kinase involved in spindle checkpoint function. Zusätzlich bieten wir Ihnen BUB1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 139 products:
Human Polyclonal BUB1 Primary Antibody für EIA, IHC (p) - ABIN360514
Shichiri, Yoshinaga, Hisatomi, Sugihara, Hirata: Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. in Cancer research 2002
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Mouse (Murine) Monoclonal BUB1 Primary Antibody für ICC, FACS - ABIN108553
Liu, Hittle, Jablonski, Campbell, Yoda, Yen: Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. in Nature cell biology 2003
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Human Monoclonal BUB1 Primary Antibody für IF, IP - ABIN181741
Vanoosthuyse, Hardwick: Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis. in Trends in cell biology 2005
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Human Polyclonal BUB1 Primary Antibody für FACS, WB - ABIN651630
Gambe, Matsunaga, Takata, Ono-Maniwa, Baba, Uchiyama, Fukui: A nucleolar protein RRS1 contributes to chromosome congression. in FEBS letters 2009
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Human Polyclonal BUB1 Primary Antibody für IHC (p), WB - ABIN392626
Cayrol, Cougoule, Wright: The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1. in Biochemical and biophysical research communications 2002
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Human Polyclonal BUB1 Primary Antibody für ELISA, WB - ABIN1452063
Cahill, da Costa, Carson-Walter, Kinzler, Vogelstein, Lengauer: Characterization of MAD2B and other mitotic spindle checkpoint genes. in Genomics 1999
Human Polyclonal BUB1 Primary Antibody für IHC, ELISA - ABIN1533511
Cahill, Lengauer, Yu, Riggins, Willson, Markowitz, Kinzler, Vogelstein: Mutations of mitotic checkpoint genes in human cancers. in Nature 1998
Chromosomal rearrangement resulting in BUB1 haploinsufficiency identified in a patient with polycystic liver disease. BUB1 may imply germline causes of genetic instability in PLD (zeige PLD Antikörper).
Results report that BubR1 (zeige BUB1B Antikörper) and RepoMan bind directly to PP2A (zeige PPP2R4 Antikörper)-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser (zeige SIGLEC1 Antikörper) residue enhances binding. RepoMan and BubR1 (zeige BUB1B Antikörper) bind B56 using both hydrophobic and electrostatic interactions.
Inhibition of Bub1 kinase impaired chromosome arm resolution but exerted only minor effects on mitotic progression or spindle assembly checkpoint function.
Study shows that BUB1beta (zeige BUB1B Antikörper) and PDZ binding kinase (zeige PBK Antikörper) are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.
Bub1 may be associated with cancer stem cell potential.
Both Bub1 and BubR1 (zeige BUB1B Antikörper) bind stably to Bub3 (zeige BUB3 Antikörper) that is required for kinetochore localization of the proteins
Bub1-Plk1 (zeige PLK1 Antikörper)-mediated phosphorylation of Cdc20 (zeige CDC20 Antikörper) constitutes an anaphase-promoting complex or cyclosome-inhibitory mechanism that is parallel, but not redundant, to mitotic checkpoint (zeige BUB3 Antikörper) complex formation.
Data show that mitotic checkpoint (zeige BUB3 Antikörper) kinase (zeige ATR Antikörper) Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop.
human BUB1 does not associate stably with the MAD2 (zeige MAD2L1 Antikörper) activator MAD1 (zeige MXD1 Antikörper) (also known as MAD1L1 (zeige MAD1L1 Antikörper)) and, although required for accelerating the loading of MAD1 (zeige MXD1 Antikörper) onto kinetochores, BUB1 is dispensable for the maintenance of steady-state levels of MAD1 (zeige MXD1 Antikörper) there
MAD2L1 (zeige MAD2L1 Antikörper) and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.
Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 (zeige BUB1B Antikörper) recruitment and localizes antagonistic checkpoint activities.
It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121.
Results establish that Bub1 has oncogenic properties and suggest that Aurora B (zeige AURKC Antikörper) is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis.
It seems that Sgo1 (zeige SGOL1 Antikörper) sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.
mutations of Bub1 and BubR1 (zeige BUB1B Antikörper) found in Brca2 (zeige BRCA2 Antikörper)- mutant mice indeed are responsible for the chromosome instability in Brca2 (zeige BRCA2 Antikörper)-mutated tumors
Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis.
Bub1 is important for mediating cell death when chromosomes missegregate.
Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.
Data show that the anaphase-promoting complex is activated in an exponential fashion after germinal vesicle breakdown in oocytes and that this process is advanced by 5 hr in oocytes lacking Bub1.
Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog
, mitotic checkpoint serine/threonine-protein kinase BUB1
, budding uninhibited by benzimidazoles 1
, budding uninhibited by benzimidazoles 1 homolog
, mitotic spindle checkpoint kinase
, putative serine/threonine-protein kinase