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BEST2 is a member of the bestrophin gene family of anion channels. Zusätzlich bieten wir Ihnen Bestrophin 2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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BEST2 and BEST4 (zeige BEST4 Antikörper) could be added to the lineage-specific genes of humans intestinal epithelial cells
Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
These data suggest that Best2 may play a functional role in the regulation of aqueous flow and drainage in humans.
identified three novel VMD2 (zeige BEST1 Antikörper)-related human genes demonstrating a high degree of conservation in their respective RFP (zeige FPR2 Antikörper)-TM domains [VMD2L1, VMD2L2 (zeige BEST4 Antikörper), VMD2L3 (zeige BEST3 Antikörper)]
we examine data obtained from tissue-type and animal models and discuss the current state of bestrophin research, what roles Best2 may play in ocular epithelia and electrophysiology, how perturbation of these functions may result in disease. [REVIEW]
Best2 plays a role in the generation of IOP by regulating formation of aqueous humor, and inhibition of Best2 function represents an attractive new avenue for regulating IOP in individuals with glaucoma.
Determined HCO3(-)/Cl(-) transport via Best2 and the effect of disease causing mutations.
suggest a role of bestrophin 1 (zeige BEST1 Antikörper) and 2 for Ca(2 (zeige CA2 Antikörper)+) dependent Cl(-) secretion in mouse airways
Asp (zeige C3 Antikörper)-rich domain has two defined binding sites and D301A and D304A mutations may impact the binding of the metal ions
Results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia.
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon.
VMD2-like gene 1
, vitelliform macular dystrophy 2-like 1
, vitelliform macular dystrophy 2-like protein 1
, bestrophin 2
, bestrophin 2 S homeolog