anti-ZAP70 (ZAP70) Antikörper

Bezeichnung:: anti-zeta-Chain (TCR) Associated Protein Kinase 70kDa Antikörper (ZAP70)

Auf www.antikoerper-online.de finden Sie aktuell 580 zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) Antikörper von 31 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ZAP70 Kits (17) und ZAP70 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 625 ZAP70 Produkte verfügbar.

Synonyme:: 70kDa, AI327364, MGC80670, MGC88962, mrtle, mur, SRK, STCD, STD, TZK, ZAP-70, ZAP70

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	ZAP70	22637	P43404
	ZAP70	301348
	ZAP70	7535	P43403
Alle Spezies anzeigen Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-ZAP70 (ZAP70) Antikörper

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anti-Mouse (Murine) ZAP70 Antikörper:

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Verknüpfte Pathways mit anti-ZAP70 Antikörper

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Am meisten referenzierte anti-ZAP70 Antikörper

Human Polyclonal ZAP70 Primary Antibody für IHC - ABIN967271 : Salomon, Ficarro, Brill, Brinker, Phung, Ericson, Sauer, Brock, Horn, Schultz, Peters: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
Show all 6 Pubmed References
Chicken Monoclonal ZAP70 Primary Antibody für IF, IP - ABIN967849 : Arpaia, Shahar, Dadi, Cohen, Roifman: Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. in Cell 1994 (PubMed)
Show all 5 Pubmed References
Chicken Monoclonal ZAP70 Primary Antibody für IF, IP - ABIN967848 : Chan, Kadlecek, Elder, Filipovich, Kuo, Iwashima, Parslow, Weiss: ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. in Science (New York, N.Y.) 1994 (PubMed)
Show all 5 Pubmed References
Human Monoclonal ZAP70 Primary Antibody für IHC (f), WB - ABIN967585 : Chan, Dalton, Johnson, Kong, Wang, Thoma, Kurosaki: Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. in The EMBO journal 1995 (PubMed)
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Human Monoclonal ZAP70 Primary Antibody für IHC, ELISA - ABIN969464 : Gelkop, Gish, Babichev, Pawson, Isakov: T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
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Human ZAP70 Primary Antibody für IHC - ABIN967269 : Kong, Dalton, Bubeck Wardenburg, Straus, Kurosaki, Chan: Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. in Molecular and cellular biology 1996 (PubMed)
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Human Monoclonal ZAP70 Primary Antibody für ICS - ABIN1176924 : Di Bartolo, Mège, Germain, Pelosi, Dufour, Michel, Magistrelli, Isacchi, Acuto: Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling. in The Journal of biological chemistry 1999 (PubMed)
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Human Monoclonal ZAP70 Primary Antibody für ICS - ABIN1177224 : Magnan, Di Bartolo, Mura, Boyer, Richelme, Lin, Roure, Gillet, Arrieumerlou, Acuto, Malissen, Malissen: T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase. in The Journal of experimental medicine 2001 (PubMed)
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Human Monoclonal ZAP70 Primary Antibody für ICS - ABIN1177223 : Rao, Lupher, Ota, Reedquist, Druker, Band: The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells. in Journal of immunology (Baltimore, Md. : 1950) 2000 (PubMed)
Show all 3 Pubmed References

Weitere Antikörper gegen ZAP70 Interaktionspartner

Mouse (Murine) zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) Interaktionspartner

disruption of normal Zap70 autoinhibition engaged negative feedback mechanisms by which negative selection and inhibitory receptors restrain TCR signaling to enforce both central and peripheral tolerance.
in this study, authors discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors, which turned them into a 'catalytic unit' that amplified antigenic stimuli
was significantly increased in 22-month AEW mice compared with 5-month AEW mice. ELISA data showed that secretions of IL-2 (zeige IL2 Antikörper) and NGF (zeige NGFB Antikörper) in 22-month AEW mice were higher than 5-month AEW mice. Our results indicate that increased ZAP70 is involved in dry skin in elderly pruritus. Increased secretion of IL-2 (zeige IL2 Antikörper) and NGF (zeige NGFB Antikörper) may induce dry skin itch.
this study shows that ZAP-70 mutation has a strong impact on T cell-driven arthritis in SKG model regardless of the genetic background
These findings establish Otud7b (zeige OTUD7B Antikörper) as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function.
Data suggest that ring finger protein 41 Nrdp1 (zeige RNF41 Antikörper) terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase.
Zap70 as a structural protein regulates integrin-mediated control of actin and with its catalytic activity regulates T cell receptor-mediated control of actin and membrane remodelling during formation of the immunological synapse.
Blockade of CXCR7 (zeige CXCR7 Antikörper) suppressed MIF (zeige MIF Antikörper)-mediated ERK (zeige EPHB2 Antikörper)- and zeta-chain-associated protein kinase (zeige CDK7 Antikörper) (ZAP)-70 activation
mediates the CD4 (zeige CD4 Antikörper) lineage differentiation in response to Class II selecting ligands
In mice with spondylarthritis, microbiota content varied according to whether T cell receptor signal strength was normal or was impaired due to the ZAP-70(W163C) mutation.

Human zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) Interaktionspartner

we have identified a new redox-active motif which is crucial for the regulation of Zap70 stability/activity. We believe that this motif has the potential to become a novel target for the development of therapeutic tools to modulate the expression/activity of kinases.
The expression of COBLL1, LPL, and ZAP70 corresponded to patient prognosis and to IGHV mutational status, although not absolutely. When we combined all three markers together and performed the ROC analysis, AUC increased compared to the AUC of individual gene expression.
The authors find that ZAP-70 selects its substrates by utilizing an electrostatic mechanism that excludes substrates with positively-charged residues and favors LAT (zeige ORC3 Antikörper) and SLP-76 (zeige LCP2 Antikörper) phosphosites that are surrounded by negatively-charged residues.
The data describe the critical early step of directional cell movement toward SDF-1 (zeige CXCL12 Antikörper) that ZAP-70 is recruited to the CXCR4 (zeige CXCR4 Antikörper) at the leading edge of membrane and consequently modulates lamellipodia/filopodia formation and integrin activation.
The study identified the criteria for the design of binders that specifically address either the Syk (zeige SYK Antikörper) or the Zap-70 Tandem Src (zeige SRC Antikörper) Homology 2 Domains, tSH2 (zeige tshz2 Antikörper). While Syk (zeige SYK Antikörper) tSH2 (zeige tshz2 Antikörper) has a rather broad substrate scope, ZAP-70 tSH2 (zeige tshz2 Antikörper) required a proximal arrangement of the phosphotyrosine ligands in defined strand orientation.
ZAP-70 signaling was impaired by cholesterol depletion, further supporting the importance of membrane organization in TCR signaling.
We conclude that ZAP70 plays a role for the homing to and/or the survival of ALL cells in the CNS and that ZAP70 may represent a therapeutic target. Furthermore, targeting CCR7 (zeige CCR7 Antikörper)/CXCR4 (zeige CXCR4 Antikörper) may be particularly promising in treating T-ALL.
The aim of this study was to evaluate the expression of ZAP70 changing during disease progression, the intracellular interferon gamma (IFN-gamma (zeige IFNG Antikörper)) and IL-4 (zeige IL4 Antikörper) content of T and B lymphocytes and the CLL cell subset (CD5 (zeige CD5 Antikörper)+CD19 (zeige CD19 Antikörper)+) in CLL patients and healthy subjects, and ZAP70 correlation with cytokine production.
in this study, authors discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors, which turned them into a 'catalytic unit' that amplified antigenic stimuli
The histological observations suggested that the patients represent diverse cases of NHL (zeige RTEL1 Antikörper) like mature B-cell type, mature T-cell type and high grade diffuse B-cell type NHL (zeige RTEL1 Antikörper). The findings indicate that patients with NHL (zeige RTEL1 Antikörper) may also be analyzed for status of PAX5 (zeige PAX5 Antikörper), CD19 (zeige CD19 Antikörper) and ZAP70, and their transcriptional and post-translational variants for the differential diagnosis of NHL (zeige RTEL1 Antikörper) and therapy.

Cow (Bovine) zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) Interaktionspartner

The surface expression of CTLA-4 (zeige CTLA4 Antikörper) was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 were decreased in CD4 (zeige CD4 Antikörper)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.

ZAP70 Antigen-Profil

Beschreibung des Gens

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Alternative names and synonyms associated with ZAP70

zeta chain of T cell receptor associated protein kinase 70kDa L homeolog (zap70.L) Antikörper
zeta chain of T cell receptor associated protein kinase 70kDa (zap70) Antikörper
zeta chain of T cell receptor associated protein kinase 70 (ZAP70) Antikörper
tyrosine-protein kinase ZAP-70 (LOC707555) Antikörper
putative tyrosine-protein kinase zap-70 (Smp_149470) Antikörper
tyrosine-protein kinase ZAP-70 (LOC100342021) Antikörper
tyrosine-protein kinase ZAP-70 (LOC100390922) Antikörper
zeta-chain (TCR) associated protein kinase 70kDa (ZAP70) Antikörper
tyrosine-protein kinase ZAP-70 (LOC100542877) Antikörper
zeta-chain (TCR) associated protein kinase (Zap70) Antikörper
zeta chain of T cell receptor associated protein kinase 70 (Zap70) Antikörper
zeta chain of T-cell receptor associated protein kinase 70 (ZAP70) Antikörper
tyrosine-protein kinase ZAP-70 (ZAP70) Antikörper
zeta-chain (TCR) associated protein kinase 70kDa (Zap70) Antikörper

70kDa Antikörper
AI327364 Antikörper
MGC80670 Antikörper
MGC88962 Antikörper
mrtle Antikörper
mur Antikörper
SRK Antikörper
STCD Antikörper
STD Antikörper
TZK Antikörper
ZAP-70 Antikörper
ZAP70 Antikörper

Bezeichner auf Proteinebene für ZAP70

zeta-chain (TCR) associated protein kinase 70kDa , zeta-chain associated protein kinase 70kDa , tyrosine-protein kinase zap-70 , tyrosine-protein kinase ZAP-70-like , 70 kDa zeta-associated protein , 70 kDa zeta-chain associated protein , syk-related tyrosine kinase , tyrosine-protein kinase ZAP-70 , syk-related protein tyrosine kinase , zeta-chain associated protein kinase, 70kD

GENE ID	SPEZIES
446840	Xenopus laevis
448557	Xenopus (Silurana) tropicalis
459427	Pan troglodytes
707555	Macaca mulatta
8343736	Schistosoma mansoni
100342021	Oryctolagus cuniculus
100390922	Callithrix jacchus
100451782	Pongo abelii
100542877	Meleagris gallopavo
100589243	Nomascus leucogenys
22637	Mus musculus
301348	Rattus norvegicus
7535	Homo sapiens
100271860	Canis lupus familiaris
100524930	Sus scrofa
504509	Bos taurus
100713473	Cavia porcellus
420086	Gallus gallus

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