ZAP70 Antikörper (zeta-Chain (TCR) Associated Protein Kinase 70kDa)

Details for Product anti-ZAP70 Antibody No. ABIN969464, Anbieter: Anmelden zum Anzeigen
Antigen
  • SRK
  • STCD
  • STD
  • TZK
  • ZAP-70
  • 70kDa
  • AI327364
  • Srk
  • mrtle
  • mur
  • zap70
  • MGC80670
  • MGC88962
  • ZAP70
  • zgc:110383
  • zeta chain of T-cell receptor associated protein kinase 70
  • putative tyrosine-protein kinase zap-70
  • zeta-chain (TCR) associated protein kinase
  • zeta chain of T cell receptor associated protein kinase 70
  • zeta-chain (TCR) associated protein kinase 70kDa
  • zeta chain of T cell receptor associated protein kinase 70kDa L homeolog
  • zeta chain of T cell receptor associated protein kinase 70kDa
  • tyrosine-protein kinase ZAP-70
  • ZAP70
  • Smp_149470
  • Zap70
  • zap70.L
  • zap70
  • LOC707555
  • LOC100342021
  • LOC100390922
  • LOC100542877
Reaktivität
Human
639
223
147
14
11
10
8
7
6
6
4
3
1
Wirt
Maus
337
284
17
3
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser ZAP70 Antikörper ist unkonjugiert
33
27
25
21
15
12
7
7
5
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
337
215
205
203
141
137
65
52
49
17
8
7
4
4
3
2
2
2
2
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Purified recombinant fragment of human ZAP70 expressed in E. Coli.
Klon 3D2A4
Isotyp IgG1
Reinigung Ascites
Plasmids, Primers & others Plasmide, Primers & weitere ZAP70 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung ZAP70 (ZAP70 Antibody Abstract)
Hintergrund ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.
Molekulargewicht 70 kDa
Gen-ID 7535
HGNC 7535
Pathways T-Zell Rezeptor Signalweg
Applikations-hinweise ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung 4°C, -20°C for long term storage
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) antibody (ABIN969464) Figure 1: Immunohistochemical analysis of paraffin-embedded human lymph tumor, showin...
Western Blotting (WB) image for anti-zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) antibody (ABIN969464) Figure 2: Western blot analysis using ZAP70 mouse mAb against Jurkat cell lysate (1) .
Produkt verwendet in: Gelkop, Gish, Babichev, Pawson, Isakov: "T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 12, pp. 8123-32, 2005 (PubMed).

Carreras, Villamor, Colomo, Moreno, Ramón y Cajal, Crespo, Tort, Bosch, López-Guillermo, Colomer, Montserrat, Campo: "Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms." in: The Journal of pathology, Vol. 205, Issue 4, pp. 507-13, 2005 (PubMed).

Hivroz: "[Everything you ever wanted to know about ZAP-70]." in: Médecine sciences : M/S, Vol. 21, Issue 2, pp. 150-5, 2005 (PubMed).

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