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anti-Human EPAS1 Antikörper:
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Fish Polyclonal EPAS1 Primary Antibody für ChIP, ELISA - ABIN151051
Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. in The Journal of biological chemistry 1999
Show all 532 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody für ChIP, ELISA - ABIN151063
Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007
Show all 154 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody für ELISA, IHC - ABIN250056
Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004
Show all 19 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody für ELISA, ICC - ABIN250055
Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. in Nature cell biology 2004
Show all 15 Pubmed References
Fish Polyclonal EPAS1 Primary Antibody für ELISA, ICC - ABIN249868
Alvarez-Tejado, Naranjo-Suarez, Jiménez, Carrera, Landázuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. in The Journal of biological chemistry 2001
Show all 17 Pubmed References
Human Monoclonal EPAS1 Primary Antibody für IHC (fro), IHC (p) - ABIN1742588
Wiesener, Turley, Allen, Willam, Eckardt, Talks, Wood, Gatter, Harris, Pugh, Ratcliffe, Maxwell: Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. in Blood 1998
Show all 4 Pubmed References
Polyclonal EPAS1 Primary Antibody für IHC (fro), IF - ABIN540619
Tian, McKnight, Russell: Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. in Genes & development 1997
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Human Polyclonal EPAS1 Primary Antibody für IF (p), IHC (p) - ABIN686662
Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. in Experimental gerontology 2016
Human Monoclonal EPAS1 Primary Antibody für IHC (p) - ABIN2473999
Pike, Phadwal, Simon, Harris: ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. in Molecular biology reports 2012
Human Monoclonal EPAS1 Primary Antibody für AA, ELISA - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009
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HIF-2alpha expression may be associated with the carcinogenesis of colorectal cancer (CRC (zeige CALR Antikörper)), which is higher in males than in females, negatively linked to tumor differentiation, and correlated with a worse disease-free survival of CRC (zeige CALR Antikörper) - Systematic Analysis
Overexpression of VHL was more successful at inhibiting fibrosis compared with silencing HIF-1a plus HIF-2a. Normoxia-active HIF-1a or HIF-2a prevented the inhibitory effect of VHL on liver fibrosis, indicating that attenuating fibrosis via VHL is HIF-1a- and HIF-2a-dependent to some extent.
HDX negatively regulates EPAS1 expression through a release-of-inhibition mechanism.
sing imputed data, we found that this SNP remained significant in the entire TRICL-ILCCO consortium (p=.03). Additional functional studies are warranted to better understand interrelationships among genetic polymorphisms, DNA methylation (zeige HELLS Antikörper) status, and EPAS1 expression.
Results suggest an interplay of the production and action of hydrogen sulfide (zeige SQRDL Antikörper) during hypoxia with subsequent erythropoietin (zeige EPO Antikörper) production regulated by HIF-1alpha (zeige HIF1A Antikörper) and HIF-2alpha.
This suggests that higher aerobic capacities are caused by the presence of at least one minor A-Allele of the EPAS1 gene in the genome of an athlete
we report a rare case of renal-cell carcinoma (zeige MOK Antikörper) and hereditary polycythemia. Genotyping revealed that the patient carried both a germline HIF2A mutation and a somatic VHL (zeige VHL Antikörper) mutation. Both mutations result in overactivation of HIF2A and its downstream target genes
Identification of gain-of-function somatic mutations of EPAS1, which encodes for HIF-2alpha, in pheochromocytomas and paragangliomas in patients who presented with cyanotic congenital heart disease.
HIF-2a regulates non-canonical glutamine (zeige GFPT1 Antikörper) metabolism via activation of PI3K (zeige PIK3CA Antikörper)/mTORC2 (zeige CRTC2 Antikörper) pathway and GOT1 (zeige GOT1 Antikörper) expression in human pancreatic ductal adenocarcinoma.
epigenomic profiling of clear cell renal cell carcinoma (zeige MOK Antikörper) (ccRCC) establishes a compendium of somatically altered cis (zeige CISH Antikörper)-regulatory elements, uncovering new potential targets including ZNF395 (zeige ZNF395 Antikörper). Loss of VHL (zeige VHL Antikörper), a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a and recruitment of histone acetyltransferase p300 (zeige EP300 Antikörper) at preexisting lineage-specific promoter-enhancer complexes
Myeloid-specific deletion of Epas1 had no impact on the number of myeloid cells migrating into the eye.
Defect in nephron formation in PHD2 (zeige EGLN1 Antikörper)/PHD3 (zeige EGLN3 Antikörper) double mutants required intact hypoxia-inducible factor-2 signaling and was dependent on the extent of stromal hypoxia-inducible factor activation. Thus, hypoxia-inducible factor prolyl-4-hydroxylation in renal interstitial cells is critical for normal nephron formation.
Absence of Hif2a in retinal neuroprogenitor cells causes a marked reduction of proliferating endothelial cells at the angiogenic front. This results in delayed retinal vascular development, fewer major retinal vessels and reduced density of the peripheral deep retinal vascular plexus.
HIF2alpha is linked to tumor suppression in neuroblastoma (zeige ARHGEF16 Antikörper).
The pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2a through interaction with CD44 (zeige CD44 Antikörper), independently of oxygen.
HIF-1alpha (zeige HIF1A Antikörper)-dependent, HIF-2alpha-independent angiogenesis and constitutive diuresis is caused by Vhl (zeige VHL Antikörper) deletion in renal epithelia
A novel biological pathway has been discovered of soluble biglycan (zeige BGN Antikörper) inducing HIF-2alpha protein stabilization and Epo (zeige EPO Antikörper) production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.
Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis.
Data show that Tet1 (zeige TET1 Antikörper) modulates HIF-2alpha and HIF-1alpha (zeige HIF1A Antikörper) through different mechanisms.
intestine HIF-2alpha regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3 (zeige Neu3 Antikörper), the gene encoding neuraminidase 3 (zeige Neu3 Antikörper). These results suggest that intestinal HIF-2alpha could be a viable target for hepatic steatosis therapy
immunostaining for HIF-1alpha (zeige HIF1A Antikörper) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a