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anti-Human EPAS1 Antikörper:
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Fish Polyclonal EPAS1 Primary Antibody für ChIP, ELISA - ABIN151051
Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. in The Journal of biological chemistry 1999
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Hamster Monoclonal EPAS1 Primary Antibody für ChIP, ELISA - ABIN151063
Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007
Show all 149 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody für ELISA, IHC - ABIN250056
Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004
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Hamster Monoclonal EPAS1 Primary Antibody für ELISA, ICC - ABIN250055
Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. in Nature cell biology 2004
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Fish Polyclonal EPAS1 Primary Antibody für ELISA, ICC - ABIN249868
Alvarez-Tejado, Naranjo-Suarez, Jiménez, Carrera, Landázuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. in The Journal of biological chemistry 2001
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Human Monoclonal EPAS1 Primary Antibody für IHC (fro), IHC (p) - ABIN1742588
Wiesener, Turley, Allen, Willam, Eckardt, Talks, Wood, Gatter, Harris, Pugh, Ratcliffe, Maxwell: Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. in Blood 1998
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Human Polyclonal EPAS1 Primary Antibody für IF (p), IHC (p) - ABIN686662
Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. in Experimental gerontology 2016
Human Monoclonal EPAS1 Primary Antibody für AA, ELISA - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009
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Human Monoclonal EPAS1 Primary Antibody für IHC (p) - ABIN2473999
Pike, Phadwal, Simon, Harris: ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. in Molecular biology reports 2012
Hamster Monoclonal EPAS1 Primary Antibody für ELISA, FACS - ABIN406865
Su, Li, Cui, Ji, Geng, Chai, Ma, Bai, Yang, Wuren, Ge, Rondina: The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. in High altitude medicine & biology 2015
The present study demonstrates that hypoxia-induced downregulation of Dicer (zeige DICER1 Antikörper) serves as key mechanism in the maintenance of the hypoxic response in HCC (zeige FAM126A Antikörper) and that prevention of hypoxic suppression of Dicer (zeige DICER1 Antikörper) not only alleviates hypoxia-induced upregulation of HIF1alpha (zeige HIF1A Antikörper) and HIF2alpha and other key hypoxia-responsive/HIF target genes, but also inhibits hypoxia-induced metastatic phenotypes such as EMT (zeige ITK Antikörper) and increased cell motility.
HIF-2alpha dictates the resistance of human pancreatic cancer cells to TRAIL under normoxic and hypoxic conditions and transcriptionally regulates survivin (zeige BIRC5 Antikörper) expression.
SOD3 (zeige SOD3 Antikörper) reduced HIF prolyl hydroxylase domain protein activity, which increased hypoxia-inducible factor-2alpha (HIF-2alpha) stability and enhanced its binding to a specific vascular endothelial cadherin (zeige CDH5 Antikörper) promoter region.
Functionally active PHD2 (zeige EGLN1 Antikörper) SNP rs516651 , located in the key pathway for the hypoxic-inflammatory response, is associated with increased 30-day mortality in Acute Respiratory Distress Syndrome (ARDS) patients. In contrast, the PHD2 (zeige EGLN1 Antikörper) SNP rs480902 is not. Furthermore, the HIF-2alpha SNP [ch2 (zeige Acyp1 Antikörper): 46441523(hg18)] GG-genotype was neither present in our ARDS patients of Caucasian heritage nor in healthy Caucasian blood donors.
We genotyped 347 Tibetan individuals from varying altitudes for both the Tibetan-specific EGLN1 haplotype and 10 candidate SNPs in the EPAS1 haplotype and correlated their association with hemoglobin levels.
HIF-2alpha plays an important role in regulating the expression of c-Myc (zeige MYC Antikörper) in chronic hypoxia, and consequently controls the sensitivity of colon cancer cells to 5-FU treatment in this environment.
The present study identifies novel HIF-2alpha-target genes that may regulate endothelial sprouting during prolonged hypoxia.
Exogenous acetate augments Acss2 (zeige ACSS2 Antikörper)/HIF-2 dependent cancer growth and metastasis in cell culture and mouse models
the structural model of the HIF2a-pVHL (zeige VHL Antikörper) complex presented in this study enhances understanding of how HIF2a is captured by pVHL (zeige VHL Antikörper). Moreover, the important contact amino acids that we identified may be useful in the development of drugs to treat HIF2a-related diseases.
Thus, we provide evidence here that HIF-2a is a critical regulator of PD-L1 (zeige CD274 Antikörper) at both mRNA and protein levels and that HIF-2a regulates the expression of PD-L1 (zeige CD274 Antikörper) by binding directly to the HRE-4 in the PD-L1 (zeige CD274 Antikörper) proximal promoter.
HIF-1alpha (zeige HIF1A Antikörper)-dependent, HIF-2alpha-independent angiogenesis and constitutive diuresis is caused by Vhl (zeige VHL Antikörper) deletion in renal epithelia
A novel biological pathway has been discovered of soluble biglycan (zeige BGN Antikörper) inducing HIF-2alpha protein stabilization and Epo (zeige EPO Antikörper) production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.
Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis.
Data show that Tet1 (zeige TET1 Antikörper) modulates HIF-2alpha and HIF-1alpha (zeige HIF1A Antikörper) through different mechanisms.
intestine HIF-2alpha regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3 (zeige Neu3 Antikörper), the gene encoding neuraminidase 3 (zeige Neu3 Antikörper). These results suggest that intestinal HIF-2alpha could be a viable target for hepatic steatosis therapy
endothelial EPAS1 has a global protective role during glomerular hypertensive injuries without influencing the hypertensive effect of angiotensin II
findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 (zeige YAP1 Antikörper) activity
Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.
this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection
in neurons HIF-1 (zeige HIF1A Antikörper) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (zeige HIF1A Antikörper)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke
immunostaining for HIF-1alpha (zeige HIF1A Antikörper) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a