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EPAS1 Antikörper (AA 1-130)

EPAS1 Reaktivität: Human, Maus, Ratte, Affe, Schaf WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN686662
  • Target Alle EPAS1 Antikörper anzeigen
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Bindungsspezifität
    • 15
    • 11
    • 9
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-130
    Reaktivität
    • 92
    • 48
    • 42
    • 17
    • 16
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Affe, Schaf
    Wirt
    • 100
    • 11
    • 1
    • 1
    Kaninchen
    Klonalität
    • 92
    • 21
    Polyklonal
    Konjugat
    • 57
    • 14
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EPAS1 Antikörper ist unkonjugiert
    Applikation
    • 92
    • 46
    • 31
    • 24
    • 14
    • 14
    • 14
    • 12
    • 12
    • 12
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Affe, Maus, Ratte, Schaf
    Homologie
    Cow,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from mouse HIF2 Alpha
    Isotyp
    IgG
    Top Product
    Discover our top product EPAS1 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Li, Chen, Shao, Tang, Chen, Chen, Xu: "Oxidative stress induces the decline of brain EPO expression in aging rats." in: Experimental gerontology, Vol. 83, pp. 89-93, (2016) (PubMed).

  • Target
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Andere Bezeichnung
    HIF2 alpha (EPAS1 Produkte)
    Synonyme
    EPAS1 antikoerper, ECYT4 antikoerper, HIF2A antikoerper, HLF antikoerper, MOP2 antikoerper, PASD2 antikoerper, bHLHe73 antikoerper, HIF-2alpha antikoerper, HRF antikoerper, Hif2a antikoerper, bhlhe73 antikoerper, ecyt4 antikoerper, hif2 antikoerper, hif2a antikoerper, hif2alpha antikoerper, hlf antikoerper, mop2 antikoerper, pasd2 antikoerper, EPAS antikoerper, EPAS-1 antikoerper, endothelial PAS domain protein 1 antikoerper, endothelial PAS domain protein 1 L homeolog antikoerper, EPAS1 antikoerper, epas1 antikoerper, Epas1 antikoerper, epas1.L antikoerper
    Hintergrund

    Synonyms: HLF, HRF, MOP2, HIF2A, bHLHe73, HIF-2alpha, Endothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, mHLF, HIF-related factor, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha, Epas1

    Background: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP3. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).

    Gen-ID
    13819
    UniProt
    P97481
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effekt
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