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EPAS1 Antikörper (AA 535-631)

EPAS1 Reaktivität: Human, Maus, Ratte, Hamster WB, ELISA, IHC, IP, FACS, ICC, IF, ChIP Wirt: Maus Monoclonal ep190b unconjugated
Produktnummer ABIN363209
  • Target Alle EPAS1 Antikörper anzeigen
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Bindungsspezifität
    • 16
    • 11
    • 9
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 535-631
    Reaktivität
    • 92
    • 48
    • 42
    • 18
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hamster
    Wirt
    • 101
    • 10
    • 1
    • 1
    Maus
    Klonalität
    • 93
    • 20
    Monoklonal
    Konjugat
    • 57
    • 14
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EPAS1 Antikörper ist unkonjugiert
    Applikation
    • 92
    • 46
    • 31
    • 23
    • 15
    • 13
    • 13
    • 13
    • 13
    • 11
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP)
    Spezifität
    Reacts with HIF-2 alpha from human, mouse hamster and rat
    Kreuzreaktivität (Details)
    Does not cross-react with HIF-1 alpha.
    Aufreinigung
    Purified (protein G)
    Immunogen
    Human HIF-2 alpha amino acids 535-631
    Klon
    Ep190b
    Isotyp
    IgG1
    Top Product
    Discover our top product EPAS1 Primärantikörper
  • Applikationshinweise

    Working dilution: Optimal dilution should be determined by the end user.
    The following are guidelines only:
    ELISA1:100-1:2000, FC1:400, IHC1:150-1:300, WB1:500

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, Sodium azide 0.1 %
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
  • Target
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Andere Bezeichnung
    Hypoxia-Inducible Factor 2-alpha (EPAS1 Produkte)
    Synonyme
    EPAS1 antikoerper, ECYT4 antikoerper, HIF2A antikoerper, HLF antikoerper, MOP2 antikoerper, PASD2 antikoerper, bHLHe73 antikoerper, HIF-2alpha antikoerper, HRF antikoerper, Hif2a antikoerper, bhlhe73 antikoerper, ecyt4 antikoerper, hif2 antikoerper, hif2a antikoerper, hif2alpha antikoerper, hlf antikoerper, mop2 antikoerper, pasd2 antikoerper, EPAS antikoerper, EPAS-1 antikoerper, endothelial PAS domain protein 1 antikoerper, endothelial PAS domain protein 1 L homeolog antikoerper, EPAS1 antikoerper, epas1 antikoerper, Epas1 antikoerper, epas1.L antikoerper
    Hintergrund
    Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
    Gen-ID
    2034
    UniProt
    Q99814
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effekt
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