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anti-Mouse (Murine) NFAT1 Antikörper:
anti-Human NFAT1 Antikörper:
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Human Monoclonal NFAT1 Primary Antibody für ChIP, ELISA - ABIN152663
Bonnet, Rochefort, Sutendra, Archer, Haromy, Webster, Hashimoto, Bonnet, Michelakis: The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 9 Pubmed References
Human Polyclonal NFAT1 Primary Antibody für IHC, IHC (p) - ABIN4339296
Quang, Leboucher, Passaro, Fuhrmann, Nourieh, Vincent-Salomon, Ghysdael: The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells. in Cell death & disease 2015
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Cow (Bovine) Polyclonal NFAT1 Primary Antibody für WB - ABIN2779960
Glud, Sørensen, Andrulis, Wang, Kondo, Jessen, Krenacs, Stelkovics, Wabl, Serfling, Palmetshofer, Pedersen: A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. in Blood 2005
Show all 3 Pubmed References
Human Polyclonal NFAT1 Primary Antibody für ICC, IF - ABIN4339295
Perotti, Baldassari, Molla, Vegetti, Bersani, Maurichi, Santinami, Anichini, Mortarini: NFATc2 is an intrinsic regulator of melanoma dedifferentiation. in Oncogene 2016
Human Polyclonal NFAT1 Primary Antibody für ELISA, IHC - ABIN4339294
Celil Aydemir, Lee, Won Kim, Gardner, Prince, Mok Ahn, Lee, Young-In Lee: Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction. in Annals of the New York Academy of Sciences 2007
NFATc2 isoform was the most highly expressed in murine microglia cultures, and inhibition or deletion of NFATc2 was sufficient to attenuate the ability of the microglia to secrete cytokines. AbetaPP/PS1 (zeige PSEN1 Antikörper) (Alzheimer's disease model) x NFATc2-/- mice had attenuated cytokine levels compared to AbetaPP/PS1 (zeige PSEN1 Antikörper) mice as well as reduced microgliosis and astrogliosis with no effect on plaque load.
data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB (zeige NFKB1 Antikörper)-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance.
These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4 (zeige CD4 Antikörper)(+) T cell exhaustion.
These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (zeige CCNE1 Antikörper) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.
Overexpression of either ca-Nfatc2 or ca-Nfatc1 (zeige NFATC1 Antikörper) in mouse islets enhanced insulin (zeige INS Antikörper) secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (zeige INS Antikörper) secretion vs. b-cell proliferation are regulated by NFAT (zeige NFATC1 Antikörper)
our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4 (zeige CD4 Antikörper)(+)/CD8 (zeige CD8A Antikörper)(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation.
It is a non-Hsp gene, which is essential for HSF1 (zeige HSF1 Antikörper)-mediated maintenance of whole body homeostasis
NFAT (zeige NFATC1 Antikörper) directs signaling enzymes to gene promoters in islets.
FOXP3 (zeige FOXP3 Antikörper) can inhibit NFAT (zeige NFATC1 Antikörper) driven expression of CD40L (zeige CD40LG Antikörper) and IL-17 (zeige IL17A Antikörper) in CD4 (zeige CD4 Antikörper) T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
Results show that NFAT1 expression is regulated by ASIC2 (zeige ACCN1 Antikörper) under acidosis and that NFAT1, binds to genes clustered in pathways involved in Rho GTPase (zeige RACGAP1 Antikörper) signaling and calcium signaling.
Our results indicate that NFATc2 may be used as an early diagnostic or predictive biomarker for colorectal carcinoma as well as a therapeutic target
NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2 (zeige SOX2 Antikörper)/ ALDH1A1 (zeige ALDH1A1 Antikörper) axis in lung adenocarcinoma.
NFATc2 and Sp1 (zeige PSG1 Antikörper) are co-localized in cell nuclei and physically interact at the NFAT (zeige NFATC1 Antikörper) target sequence termed NFAT (zeige NFATC1 Antikörper)-responsive promotor construct. Sp1 (zeige PSG1 Antikörper) increases the functional activity of its binding partner NFATc2.
Our data have shown for the first time the regulation of CacyBP/SIP (zeige CACYBP Antikörper) gene expression by NFAT1. Since NFAT (zeige NFATC1 Antikörper) transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP (zeige CACYBP Antikörper) in the immune system.
An interaction of NFAT1 and the beta-catenin (zeige CTNNB1 Antikörper) pathway, validate lysophosphatidic acid as an in vivo activator of beta-catenin (zeige CTNNB1 Antikörper)-dependent transcription during allograft fibrogenesis.
the expression of NFATc2 promotes melanoma dedifferentiation and immune escape
NFAT1 is stimulated by subplasmalemmal Ca2 (zeige CA2 Antikörper)+ microdomains, whereas NFAT4 (zeige NFATC3 Antikörper) additionally requires Ca2 (zeige CA2 Antikörper)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.
NFAT1 overexpression is associated with Melanoma Tumor Growth and Metastasis.
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
, nuclear factor of activated T-cells, cytoplasmic 2-like
, NFAT pre-existing subunit
, T-cell transcription factor NFAT1
, nuclear factor of activated T-cells, cytoplasmic 2
, NFAT transcription complex, preexisting component
, T cell transcription factor NFAT1
, nuclear factor of activated T-cells, preexisting component
, preexisting nuclear factor of activated T-cells 2