anti-NFAT1 (NFAT1) Antikörper

Bezeichnung:: anti-Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Antikörper (NFAT1)

Auf www.antikoerper-online.de finden Sie aktuell 164 Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Antikörper von 24 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen NFAT1 Kits (8) und NFAT1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 186 NFAT1 Produkte verfügbar.

Synonyme:: AI607462, NF-ATc2, NFAT1, NFAT1-D, NFATC2, NFATP

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	NFAT1	18019	Q60591
	NFAT1	4773	Q13469
	NFAT1	311658
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Mouse (Murine) NFAT1 Antikörper:

anti-Human NFAT1 Antikörper:

anti-Rat (Rattus) NFAT1 Antikörper:

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Verknüpfte Pathways mit anti-NFAT1 Antikörper

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Am meisten referenzierte anti-NFAT1 Antikörper

Human Monoclonal NFAT1 Primary Antibody für ChIP, ELISA - ABIN152663 : Bonnet, Rochefort, Sutendra, Archer, Haromy, Webster, Hashimoto, Bonnet, Michelakis: The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
Show all 9 Pubmed References
Cow (Bovine) Polyclonal NFAT1 Primary Antibody für WB - ABIN2779960 : Glud, Sørensen, Andrulis, Wang, Kondo, Jessen, Krenacs, Stelkovics, Wabl, Serfling, Palmetshofer, Pedersen: A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. in Blood 2005 (PubMed)
Show all 3 Pubmed References
Human Polyclonal NFAT1 Primary Antibody für IHC, IHC (p) - ABIN4339296 : Quang, Leboucher, Passaro, Fuhrmann, Nourieh, Vincent-Salomon, Ghysdael: The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells. in Cell death & disease 2015 (PubMed)
Show all 2 Pubmed References
Human Polyclonal NFAT1 Primary Antibody für ELISA, IHC - ABIN4339294 : Celil Aydemir, Lee, Won Kim, Gardner, Prince, Mok Ahn, Lee, Young-In Lee: Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction. in Annals of the New York Academy of Sciences 2007 (PubMed)
Human Polyclonal NFAT1 Primary Antibody für ICC, IF - ABIN4339295 : Perotti, Baldassari, Molla, Vegetti, Bersani, Maurichi, Santinami, Anichini, Mortarini: NFATc2 is an intrinsic regulator of melanoma dedifferentiation. in Oncogene 2016 (PubMed)

Weitere Antikörper gegen NFAT1 Interaktionspartner

Mouse (Murine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Interaktionspartner

NFATc2 isoform was the most highly expressed in murine microglia cultures, and inhibition or deletion of NFATc2 was sufficient to attenuate the ability of the microglia to secrete cytokines. AbetaPP/PS1 (zeige PSEN1 Antikörper) (Alzheimer's disease model) x NFATc2-/- mice had attenuated cytokine levels compared to AbetaPP/PS1 (zeige PSEN1 Antikörper) mice as well as reduced microgliosis and astrogliosis with no effect on plaque load.
data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB (zeige NFKB1 Antikörper)-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance.
These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4 (zeige CD4 Antikörper)(+) T cell exhaustion.
These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (zeige CCNE1 Antikörper) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.
Overexpression of either ca-Nfatc2 or ca-Nfatc1 (zeige NFATC1 Antikörper) in mouse islets enhanced insulin (zeige INS Antikörper) secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (zeige INS Antikörper) secretion vs. b-cell proliferation are regulated by NFAT (zeige NFATC1 Antikörper)
our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4 (zeige CD4 Antikörper)(+)/CD8 (zeige CD8A Antikörper)(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation.
It is a non-Hsp gene, which is essential for HSF1 (zeige HSF1 Antikörper)-mediated maintenance of whole body homeostasis
NFAT (zeige NFATC1 Antikörper) directs signaling enzymes to gene promoters in islets.
FOXP3 (zeige FOXP3 Antikörper) can inhibit NFAT (zeige NFATC1 Antikörper) driven expression of CD40L (zeige CD40LG Antikörper) and IL-17 (zeige IL17A Antikörper) in CD4 (zeige CD4 Antikörper) T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

Human Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Interaktionspartner

Results show that NFAT1 expression is regulated by ASIC2 (zeige ACCN1 Antikörper) under acidosis and that NFAT1, binds to genes clustered in pathways involved in Rho GTPase (zeige RACGAP1 Antikörper) signaling and calcium signaling.
Our results indicate that NFATc2 may be used as an early diagnostic or predictive biomarker for colorectal carcinoma as well as a therapeutic target
NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2 (zeige SOX2 Antikörper)/ ALDH1A1 (zeige ALDH1A1 Antikörper) axis in lung adenocarcinoma.
NFATc2 and Sp1 (zeige PSG1 Antikörper) are co-localized in cell nuclei and physically interact at the NFAT (zeige NFATC1 Antikörper) target sequence termed NFAT (zeige NFATC1 Antikörper)-responsive promotor construct. Sp1 (zeige PSG1 Antikörper) increases the functional activity of its binding partner NFATc2.
Our data have shown for the first time the regulation of CacyBP/SIP (zeige CACYBP Antikörper) gene expression by NFAT1. Since NFAT (zeige NFATC1 Antikörper) transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP (zeige CACYBP Antikörper) in the immune system.
An interaction of NFAT1 and the beta-catenin (zeige CTNNB1 Antikörper) pathway, validate lysophosphatidic acid as an in vivo activator of beta-catenin (zeige CTNNB1 Antikörper)-dependent transcription during allograft fibrogenesis.
the expression of NFATc2 promotes melanoma dedifferentiation and immune escape
NFAT1 is stimulated by subplasmalemmal Ca2 (zeige CA2 Antikörper)+ microdomains, whereas NFAT4 (zeige NFATC3 Antikörper) additionally requires Ca2 (zeige CA2 Antikörper)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.
NFAT1 overexpression is associated with Melanoma Tumor Growth and Metastasis.
These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (zeige CCNE1 Antikörper) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.

NFAT1 Antigen-Profil

Beschreibung des Gens

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Alternative names and synonyms associated with NFAT1

nuclear factor of activated T-cells 2 (NFATC2) Antikörper
nuclear factor of activated T-cells 2 (nfatc2) Antikörper
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 (Nfatc2) Antikörper
nuclear factor of activated T-cells 2 (Nfatc2) Antikörper

AI607462 Antikörper
NF-ATc2 Antikörper
NFAT1 Antikörper
NFAT1-D Antikörper
NFATC2 Antikörper
NFATP Antikörper

Bezeichner auf Proteinebene für NFAT1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 , nuclear factor of activated T-cells, cytoplasmic 2-like , NF-ATp , NFAT pre-existing subunit , T-cell transcription factor NFAT1 , nuclear factor of activated T-cells, cytoplasmic 2 , NF-ATc2 , NFAT transcription complex, preexisting component , T cell transcription factor NFAT1 , nuclear factor of activated T-cells, preexisting component , preexisting nuclear factor of activated T-cells 2

GENE ID	SPEZIES
100052657	Equus caballus
469972	Pan troglodytes
100450332	Pongo abelii
100464798	Ailuropoda melanoleuca
100542144	Meleagris gallopavo
100556205	Anolis carolinensis
100599959	Nomascus leucogenys
710601	Macaca mulatta
100414856	Callithrix jacchus
100490186	Xenopus (Silurana) tropicalis
18019	Mus musculus
4773	Homo sapiens
311658	Rattus norvegicus
485930	Canis lupus familiaris
100134969	Sus scrofa
530401	Bos taurus
419346	Gallus gallus

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Show all anti-Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Antikörper with Pubmed References

Mouse (Murine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Interaktionspartner

Human Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with NFAT1

Bezeichner auf Proteinebene für NFAT1