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anti-Rat (Rattus) PTBP1 Antikörper:
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Human Polyclonal PTBP1 Primary Antibody für WB - ABIN1881702
Osada, Uno, Mineta, Kameoka, Takahashi, Terao: Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta. in Molecular ecology 2010
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Human Polyclonal PTBP1 Primary Antibody für IHC (p), IHC - ABIN250017
Cote, Zhu, Thomas, Martin, Murad, Sharina: Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells. in PLoS ONE 2012
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Cow (Bovine) Polyclonal PTBP1 Primary Antibody für WB - ABIN2778815
Somberg, Zhao, Fröhlich, Evander, Schwartz: Polypyrimidine tract binding protein induces human papillomavirus type 16 late gene expression by interfering with splicing inhibitory elements at the major late 5' splice site, SD3632. in Journal of virology 2008
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inactivation of both exosc9, which encodes a component of the RNA exosome, and ptbp1, which encodes an RNA-binding protein abundant in Xenopus embryonic skin, impairs embryonic Xenopus skin development.
Polypyrimidine tract binding protein prevents activity of an intronic regulatory element that promotes usage of a composite 3'-terminal exon
PTBP1 is a novel regulator of MCL1 (zeige MCL1 Antikörper) mRNA by which it controls apoptotic response to antitubulin chemotherapeutics.
PTB interacts specifically with 3'UTR (zeige UTS2R Antikörper) of p53 (zeige TP53 Antikörper) mRNA and positively regulates expression of p53 (zeige TP53 Antikörper) isoforms. PTB showed some overlapping binding regions in the p53 (zeige TP53 Antikörper) 3'UTR (zeige UTS2R Antikörper) with miR (zeige MLXIP Antikörper)-1285. Knockdown of miR (zeige MLXIP Antikörper)-1285 as well as expression of p53 (zeige TP53 Antikörper) 3'UTR (zeige UTS2R Antikörper) with mutated miR (zeige MLXIP Antikörper)-1285 binding sites resulted in enhanced association of PTB with the 3'UTR (zeige UTS2R Antikörper), which provides mechanistic insights of this interplay.
It has been established that PTBP1 and PTBP2 (zeige PTBP2 Antikörper) are members of a family of cryptic exon repressors.
These results demonstrate that during early stages of splicing, exon RNP (zeige RNPC3 Antikörper) complexes are highly dynamic with many proteins failing to bind during PTBP1 arrest.
Studied interactions of polypyrimidine tract-binding protein (PTBP1), pyruvate kinase M2 (PKM2), and STAT3 (signal transducer and activator of transcription 3 (zeige STAT3 Antikörper)) in oncogenesis of anaplastic large cell lymphoma (ALCL). Results show that in ALCL cells, PTBP1 is crucial for PKM2 phosphorylation of STAT3 (zeige STAT3 Antikörper) in the nucleus.
Expression of ATG10 (zeige ATG10 Antikörper) negatively regulated by PTBP1 and is associated with metastasis of colorectal cancer cells.
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm.
follow-up molecular analyses of one splicing factor (zeige SLU7 Antikörper) PTBP1 revealed its impact on disease-associated splicing patterns in Huntington's disease (HD). Collectively, our data provide genomic evidence for widespread splicing dysregulation in HD brains, and suggest the role of aberrant alternative splicing in the pathogenesis of HD
CD5 (zeige CD5 Antikörper) transcription is increased, leading to the production of three mRNA isoforms by APA (zeige ENPEP Antikörper), all contributing for protein production, at different levels. PTBP1 binds in the vicinity of pA1 (zeige PAGR1 Antikörper), leading to an increase in mRNA levels and miR (zeige MLXIP Antikörper)-204 targets the longer CD5 (zeige CD5 Antikörper) mRNA.
Increased expression of microRNA miR (zeige MLXIP Antikörper)-145 combined with knockdown of PTBP1 protein contributed to the greater and longer growth suppression compared with each single treatment.
In round spermatids, MRG15 (zeige MORF4L1 Antikörper) colocalizes with splicing factors PTBP1 and PTBP2 (zeige PTBP2 Antikörper) at H3K36me3 sites between the exons and single intron of transition nuclear protein 2 (Tnp2 (zeige TNP2 Antikörper)). Thus, our results reveal that MRG15 (zeige MORF4L1 Antikörper) is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder
This knockin Ptbp1 rescued a forebrain-specific, but not a pan (zeige SUPT6H Antikörper)-neuronal, Ptbp2 (zeige PTBP2 Antikörper) knockout, demonstrating both redundant and distinct roles for the proteins. Many developmentally regulated exons exhibited different sensitivities to PTBP1 and PTBP2 (zeige PTBP2 Antikörper).
Results indicate that heterogeneous nuclear ribonucleoprotein I (hnRNPI) plays a critical role in establishing neonatal immune adaptation and preventing colitis and colorectal cancer.
Thus, PTBP1 controls the activity of Pbx1 (zeige PBX1 Antikörper) to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.
showed polypyrimidine tract binding protein (PTBP)-dependent alternative splicing of CaMKIIalpha (zeige CAMK2 Antikörper) transcripts in the lens
This may account for the tight correlation between Hps1 with Ptbp1 expression levels observed across mammalian tissues.
The expression levels of three splicing factors, ESRP1 (zeige ESRP1 Antikörper), PTB and SF2/ASF (zeige SRSF1 Antikörper), are significantly altered during cardiac hypertrophy in mice.
Study reports that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR (zeige MLXIP Antikörper)-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons.
The polypyrimidine tract binding proteins PTBP1 and PTBP2 (zeige PTBP2 Antikörper) repressed Psd-95 (zeige DLG4 Antikörper) (also known as Dlg4 (zeige DLG4 Antikörper)) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay.
PTBP1 is not required for the earliest isovolumetric divisions and differentiation steps of the zygote up to the formation of the blastocyst.
Data report on a zebrafish maternal-effect (zeige NLRP5 Antikörper) mutant, brom bones, which is defective in the cytosolic Ca(2 (zeige CA2 Antikörper)+) rise and subsequent egg activation events, including cortical granule exocytosis and cytoplasmic segregation [brom bones].
Two stretches of polypyrimidine tracts designated PPT1 and PPT2 which influence the IRES activity of cx55.5 protein were identified; deletion of PPT1 results in an appreciable decrease of the IRES activity
PTB1 is a splicing factor (zeige SLU7 Antikörper) that influences alternative splicing and acts at the polypyrimidine tract.
Alternative splicing (AS) patterns as well as the expression of key flowering regulators were massively changed in a PTB1/2 level-dependent manner.
AtPTB1 and AtPTB2 are widely expressed in almost all tissues, with the highest expression levels in late-maturing and mature pollen grains, and are crucial for pollen germination. [AtPTB1]
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
polypyrimidine tract binding protein 1
, hnrnp I
, hnRNP I-related RNA transport protein VgRBP60
, polypyrimidine tract-binding protein
, polypyrimidine tract-binding protein 1
, 57 kDa RNA-binding protein PPTB-1
, RNA-binding protein
, heterogeneous nuclear ribonucleoprotein I
, heterogeneous nuclear ribonucleoprotein polypeptide I
, hnRNP I
, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
, pyrimidine binding protein 1
, pyrimidine binding protein 2
, brom bones