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PTBP1 Produkte

(Polypyrimidine Tract Binding Protein 1 (PTBP1))

Kategorien

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

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Ausgewählte PTBP1 Kategorien

PTBP1 Antikörper

High quality antibodies with extensive validation data.

PTBP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

PTBP1 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene PTBP1 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Applikation IHC, ELISA, WB
Validierungen
  • (7)
Kat. Nr. ABIN185079
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation IF, IHC (p), IP, ELISA, WB
Validierungen
  • (7)
Kat. Nr. ABIN562502
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation IF, IHC, WB
Validierungen
  • (5)
Kat. Nr. ABIN7009783
Menge 60 μL
Datenblatt Datenblatt

Empfohlene PTBP1 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6206857
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN5592507
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN2870199
Menge 96 tests
Datenblatt Datenblatt

Empfohlene PTBP1 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3133144
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1316690
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1316692
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren PTBP1 Produkten

Wei, Dai, Zhou, He, Yao, Zhao, Guo, Yang: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." in: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).

Cote, Zhu, Thomas, Martin, Murad, Sharina: "Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells." in: PLoS ONE, Vol. 7, Issue 7, pp. e41099, (2012) (PubMed).

Osada, Uno, Mineta, Kameoka, Takahashi, Terao: "Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta." in: Molecular ecology, Vol. 19, Issue 14, pp. 2884-95, (2010) (PubMed).

Kanda, Gauss-Müller, Cordes, Tamura, Okitsu, Shuang, Nakamoto, Fujiwara, Imazeki, Yokosuka: "Hepatitis A virus (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein." in: Journal of viral hepatitis, Vol. 17, Issue 9, pp. 618-23, (2010) (PubMed).

Verma, Bhattacharyya, Das: "Polypyrimidine tract-binding protein interacts with coxsackievirus B3 RNA and influences its translation." in: The Journal of general virology, Vol. 91, Issue Pt 5, pp. 1245-55, (2010) (PubMed).

Maynard, Hall: "Interactions between PTB RRMs induce slow motions and increase RNA binding affinity." in: Journal of molecular biology, Vol. 397, Issue 1, pp. 260-77, (2010) (PubMed).

Xue, Zhou, Wu, Zhu, Ji, Kwon, Zhang, Yeo, Black, Sun, Fu, Zhang: "Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping." in: Molecular cell, Vol. 36, Issue 6, pp. 996-1006, (2010) (PubMed).

Clower, Chatterjee, Wang, Cantley, Vander Heiden, Krainer: "The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 1894-9, (2010) (PubMed).

Charlet-B, Logan, Singh, Cooper: "Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing." in: Molecular cell, Vol. 9, Issue 3, pp. 649-58, (2002) (PubMed).

Synonyme und alternative Namen zu PTBP1

polypyrimidine tract binding protein 1 (PTBP1), polypyrimidine tract binding protein 1 S homeolog (ptbp1.S), polypyrimidine tract-binding protein (NAEGRDRAFT_80143), polypyrimidine tract-binding protein (LOC100285404), polypyrimidine tract binding protein 1 (Ptbp1), polypyrimidine tract binding protein 1a (ptbp1a), polypyrimidine tract binding protein 1 L homeolog (ptbp1.L), polypyrimidine tract-binding protein 1 (PTB1), polypyrimidine tract-binding protein 1 (LOC100061673), AA407203, AL033359, ATPTB1, HNRNP-I, hnrnp-I, HNRNPI, HNRPI, hnrpi, POLYPYRIMIDINE TRACT-BINDING, POLYPYRIMIDINE TRACT-BINDING PROTEIN 1, polypyrimidine tract-binding protein 1, pPTB, PTB, Ptb, ptb, PTB-1, PTB-T, PTB2, PTB3, PTB4, ptbp1, PTBP1, Pybp, Pybp1, Pybp2, T4P13.16, T4P13_16, vgrbp60, wu:fb99f12, zgc:110689

Bezeichner auf Proteinebene für PTBP1

  • 57 kDa RNA-binding protein PPTB-1
  • RNA-binding protein
  • heterogeneous nuclear ribonucleoprotein I
  • heterogeneous nuclear ribonucleoprotein polypeptide I
  • hnRNP I
  • polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)
  • polypyrimidine tract-binding protein 1
  • polypyrimidine tract binding protein 1
  • hnrnp I
  • hnRNP I-related RNA transport protein VgRBP60
  • polypyrimidine tract-binding protein
  • pyrimidine binding protein 1
  • pyrimidine binding protein 2
  • brb
  • brom bones
  • PTB
  • LOW QUALITY PROTEIN: polypyrimidine tract-binding protein 1
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