anti-WWTR1 (WWTR1) Antikörper

Zebrafish WW Domain Containing Transcription Regulator 1 (WWTR1) Interaktionspartner

1. Yap (zeige YAP1 Antikörper)/Taz (zeige TAZ Antikörper)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.

2. Taz (zeige TAZ Antikörper) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.

3. Taz (zeige TAZ Antikörper)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles

4. When transcriptional coactivators Yap (zeige YAP1 Antikörper) and Taz (zeige TAZ Antikörper) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.

5. TAZ (zeige TAZ Antikörper) has a critical role in osteoblast differentiation in vivo

Human WW Domain Containing Transcription Regulator 1 (WWTR1) Interaktionspartner

1. this study identified TAZ (zeige TAZ Antikörper) as a novel inducer of lung cancer stem cells and the first transcriptional activator of the stem cell marker ALDH1A1 (zeige ALDH1A1 Antikörper)

2. Rottlerin exerted its tumor suppressive function via inactivation of TAZ (zeige TAZ Antikörper) in non-small cell lung carcinoma cells.

3. These results indicate that TAZ (zeige TAZ Antikörper) is an independent prognostic factor and plays an important role in Non-Small Cell lung cancer (NSCLC)progression and may serve as a novel therapeutic target of NSCLC.

4. TAZ (zeige TAZ Antikörper) is overexpressed in glioma and translocated more into nucleus in high grade glioma. TAZ (zeige TAZ Antikörper) is involved in gliomagenesis by promoting glioma growth and may benefit to epithelial mesenchymal transformation.

5. TAZ (zeige TAZ Antikörper) may be implicated in the proliferation and migration of hDPSCs.

6. YAP (zeige YAP1 Antikörper)/ TAZ (zeige TAZ Antikörper) pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 (zeige CCNE1 Antikörper) and CREB (zeige CREB1 Antikörper)

7. FZD7 (zeige FZD7 Antikörper) may promote glioma cell proliferation via upregulation of TAZ (zeige TAZ Antikörper).

8. this study indicates that TAZ (zeige TAZ Antikörper) proteins are linked to prognosis and therefore could be therapeutic targets in conventional osteosarcomas

9. These results demonstrate a critical role of the activation of YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) by disturbed flow in promoting atheroprone phenotypes and atherosclerotic lesion development.

10. These findings uncover a suppressive role of SYNPO2 (zeige SYNPO2 Antikörper) in triple-negative breast cancer (TNBC) metastasis via inhibition of YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper), and suggest that SYNPO2 (zeige SYNPO2 Antikörper) might provide a potential prognosis marker and novel therapeutic strategy.

Mouse (Murine) WW Domain Containing Transcription Regulator 1 (WWTR1) Interaktionspartner

1. A crucial role for YAP (zeige YAP1 Antikörper) and TAZ (zeige TAZ Antikörper) in the maintenance of the postnatal adrenal cortex.

2. TAZ (zeige TAZ Antikörper) is a critical factor for SRC kinase (zeige CSK Antikörper)-mediated intestinal tumor formation and regeneration.

3. YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) plays multifaceted roles for endothelial cell behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation

4. Yap (zeige YAP1 Antikörper) and Taz (zeige TAZ Antikörper) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (zeige ITK Antikörper)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.

5. This study identifies YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) as central mediators of VEGF (zeige VEGFA Antikörper) signaling

6. TAZ (zeige TAZ Antikörper) is required for TGFbeta (zeige TGFB1 Antikörper) induction of smooth muscle genes and is also required for the differentiated VSMC phenotype; synergy between TAZ (zeige TAZ Antikörper) and SRF, and TAZ (zeige TAZ Antikörper) and Myocardin (zeige MYOCD Antikörper) (MyoC856), in regulating smooth muscle gene activation was observed in primary aortic vascular smooth muscle cells.

7. Results demonstrate a pivotal role for TAZ (zeige TAZ Antikörper) in regulating the differentiation of Treg cells and TH17 cells.

8. ABL (zeige ABL1 Antikörper) potentiated the assembly and activation of the RUNX2 (zeige RUNX2 Antikörper)-TAZ (zeige TAZ Antikörper) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (zeige PPARG Antikörper)-mediated adipogenesis.

9. the transcription regulators YAP (zeige YAP1 Antikörper) and TAZ (zeige TAZ Antikörper) localise to the nucleus in the basal layer of skin and are elevated upon wound healing.

10. These results suggest that vinculin (zeige VCL Antikörper) promotes the nuclear localization of transcription factor TAZ (zeige TAZ Antikörper) to inhibit the adipocyte differentiation on rigid extracellular matrix.