anti-WWTR1 (WWTR1) Antikörper

Zebrafish WW Domain Containing Transcription Regulator 1 (WWTR1) Interaktionspartner

1. The authors show that the Hippo pathway transcriptional coactivators Yap1 (zeige YAP1 Antikörper) and Wwtr1 are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin (zeige FN1 Antikörper) assembly underneath the presumptive epidermis and surrounding the notochord.

2. Altogether, the data suggest that Wwtr1 establishes the compact wall architecture necessary for trabeculation, and that Nrg/Erbb2 (zeige ERBB2 Antikörper) signaling negatively regulates its nuclear localization and therefore its activity.

3. Yap (zeige YAP1 Antikörper)/Taz (zeige TAZ Antikörper)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.

4. Taz (zeige TAZ Antikörper) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.

5. Taz (zeige TAZ Antikörper)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles

6. When transcriptional coactivators Yap (zeige YAP1 Antikörper) and Taz (zeige TAZ Antikörper) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.

7. TAZ (zeige TAZ Antikörper) has a critical role in osteoblast differentiation in vivo

Pig (Porcine) WW Domain Containing Transcription Regulator 1 (WWTR1) Interaktionspartner

1. MRTF is essential for TAZ (zeige TAZ Antikörper) expression; TAZ (zeige TAZ Antikörper) and MRTF inhibit each other's cytosolic mobility and stimulus-induced nuclear accumulation; they antagonize each other's stimulatory effect on the alpha-smooth muscle actin (zeige ACTG2 Antikörper) promoter, which harbours nearby cis (zeige CISH Antikörper)-elements for both, but synergize on isolated TEAD-elements.

Human WW Domain Containing Transcription Regulator 1 (WWTR1) Interaktionspartner

1. functional evaluation of a HTM cell monolayer using a permeability assay demonstrated that the inhibition of YAP (zeige YAP1 Antikörper) and TAZ (zeige TAZ Antikörper) attenuated the DEX-induced impairment of permeability. These findings suggest that YAP (zeige YAP1 Antikörper) and TAZ (zeige TAZ Antikörper) play pivotal roles in the DEX-induced cytoskeletal changes of HTM cells, and reveal novel potential mechanisms for the development and progression of glaucoma

2. WWTR1 promotes cell proliferation and inhibits apoptosis of GC cells by regulating cell cycle/apoptosisassociated factors, and effectors in the TGFbeta (zeige TGFB1 Antikörper) pathway.

3. EphA2 (zeige EPHA2 Antikörper)-mediates glutaminolysis through YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) activation in HER2 (zeige ERBB2 Antikörper)-positive breast cancer and may serve as potential therapeutic targets in patients.

4. Depletion of either YES-associated protein (YAP (zeige YAP1 Antikörper)) or transcriptional coactivator with PDZ (zeige INADL Antikörper)-motif (TAZ (zeige TAZ Antikörper)) sensitised cancer cell lines to MLN8237, resulting in apoptosis and reduction in aurora-A (zeige AURKA Antikörper).

5. High TAZ (zeige TAZ Antikörper) expression is associated with breast cancer.

6. Nuclear localization of YAP (zeige YAP1 Antikörper) and TAZ (zeige TAZ Antikörper) was reduced in DMOG-treated primary tubular epithelial cells.

7. SnoN (zeige SKIL Antikörper) interacts with multiple components of the Hippo pathway to inhibit the binding of Lats2 to TAZ (zeige TAZ Antikörper) and the subsequent phosphorylation of TAZ (zeige TAZ Antikörper), leading to TAZ (zeige TAZ Antikörper) stabilization.

8. Results show that YAP (zeige YAP1 Antikörper) and TAZ (zeige TAZ Antikörper) transcription are regulated by Cbx7 (zeige CBX7 Antikörper) inhibiting glioblasoma cell migration.

9. Besides its role in normal tissue development, TAZ (zeige TAZ Antikörper) plays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT (zeige ITK Antikörper)), and stemness in multiple human cancers.

10. Together, these data illustrate that YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) signaling is responsive to hydrogel stiffness and degradability, but the outcome is dependent on the dimensionality of cell-biomaterial interactions.

Mouse (Murine) WW Domain Containing Transcription Regulator 1 (WWTR1) Interaktionspartner

1. MOB1 (zeige HOPX Antikörper)-dependent YAP1 (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper)-TEAD complex functions as a transcriptional repressor of SOX9 (zeige SOX9 Antikörper) and thereby negatively regulates chondrogenesis.

2. TAZ (zeige TAZ Antikörper) regulates cell fate depends on not only the cell type but also its subcellular localization.

3. The results suggested that TAZ (zeige TAZ Antikörper) may suppress apoptosis and premature senescence in spermatogenic cells by inhibiting the p53 (zeige TP53 Antikörper)-p21 (zeige D4S234E Antikörper) signaling pathway, thus playing important roles in the maintenance and control of reproductive function.

4. The role of Yap (zeige YAP1 Antikörper) and Wwtr1 in the Hippo signaling pathway and the regulation of spermatogenesis in mice are reported.

5. Taz (zeige TAZ Antikörper) and Yap (zeige YAP1 Antikörper) have overlapping functions in promoting myoblast proliferation but Taz (zeige TAZ Antikörper) then switches to enhance myogenic differentiation.

6. A crucial role for YAP (zeige YAP1 Antikörper) and TAZ (zeige TAZ Antikörper) in the maintenance of the postnatal adrenal cortex.

7. TAZ (zeige TAZ Antikörper) is a critical factor for SRC kinase (zeige CSK Antikörper)-mediated intestinal tumor formation and regeneration.

8. YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) plays multifaceted roles for endothelial cell behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation

9. Yap (zeige YAP1 Antikörper) and Taz (zeige TAZ Antikörper) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (zeige ITK Antikörper)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.

10. This study identifies YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) as central mediators of VEGF (zeige VEGFA Antikörper) signaling