WWTR1 Antikörper (C-Term)

Produktnummer ABIN7271395

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch WWTR1 in WB und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für WWTR1 Antikörper (C-Term) (ABIN7271395)

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWTR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-WWTR1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: TAZ Rabbit pAb

Sequenz: LNGGPYHSRE QSTDSGLGLG CYSVPTTPED FLSNVDEMDT GENAGQTPMN INPQQTRFPD FLDCLPGTNV DLGTLESEDL IPLFNDVESA LNKSEPFLTW L

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human TAZ (NP_056287.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu WWTR1

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Andere Bezeichnung: WWTR1

Hintergrund: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.,WW domain-containing transcription regulator protein 1,Transcriptional coactivator with PDZ-binding motif,TAZ,WWTR1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Stem Cells,Mesenchymal Stem Cells,WWTR1

Molekulargewicht: 44kDa

Gen-ID: 25937

UniProt: Q9GZV5

Pathways: Regulation of Lipid Metabolism by PPARalpha