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WWTR1 Antikörper (C-Term)

WWTR1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB51589 unconjugated
Produktnummer ABIN6243336
  • Target Alle WWTR1 Antikörper anzeigen
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    Bindungsspezifität
    • 10
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 296-330, C-Term
    Reaktivität
    • 37
    • 16
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 33
    • 4
    Kaninchen
    Klonalität
    • 33
    • 4
    Polyklonal
    Konjugat
    • 22
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser WWTR1 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 16
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    M
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This WWTR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 296-330 amino acids from the C-terminal region of human WWTR1.
    Klon
    RB51589
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product WWTR1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
    Andere Bezeichnung
    WWTR1 (WWTR1 Produkte)
    Synonyme
    WWTR1 antikoerper, TAZ antikoerper, 2310058J06Rik antikoerper, 2610021I22Rik antikoerper, C78399 antikoerper, Taz antikoerper, WW domain containing transcription regulator 1 L homeolog antikoerper, WW domain containing transcription regulator 1 antikoerper, wwtr1.L antikoerper, wwtr1 antikoerper, WWTR1 antikoerper, Wwtr1 antikoerper
    Hintergrund
    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
    Molekulargewicht
    44101
    UniProt
    Q9GZV5
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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