TLR3 Protein
Kurzübersicht für TLR3 Protein (ABIN935864)
Target
Alle TLR3 Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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                                            Sequenz
- STTKCTVSHE VADCSHLKLT QVPDDLPTNI TVLNLTHNQL RRLPAANFTR YSQLTSLDVG FNTISKLEPE LCQKLPMLKV LNLQHNELSQ LSDKTFAFCT NLTELHLMSN SIQKIKNNPF VKQKNLITLD LSHNGLSSTK LGTQVQLENL QELLLSNNKI QALKSEELDI FANSSLKKLE LSSNQIKEFS PGCFHAIGRL FGLFLNNVQL GPSLTEKLCL ELANTSIRNL SLSNSQLSTT SNTTFLGLKW TNLTMLDLSY NNLNVVGNDS FAWLPQLEYF FLEYNNIQHL FSHSLHGLFN VRYLNLKRSF TKQSISLASL PKIDDFSFQW LKCLEHLNME DNDIPGIKSN MFTGLINLKY LSLSNSFTSL RTLTNETFVS LAHSPLHILN LTKNKISKIE SDAFSWLGHL EVLDLGLNEI GQELTGQEWR GLENIFEIYL SYNKYLQLTR NSFALVPSLQ RLMLRRVALK NVDSSPSPFQ PLRNLTILDL SNNNIANIND DMLEGLEKLE ILDLQHNNLA RLWKHANPGG PIYFLKGLSH LHILNLESNG FDEIPVEVFK DLFELKIIDL GLNNLNTLPA SVFNNQVSLK SLNLQKNLIT SVEKKVFGPA FRNLTELDMR FNPFDCTCES IAWFVNWINE THTNIPELSS HYLCNTPPHY HGFPVRLFDT SSCKDSAPFE L
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                                            Produktmerkmale
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                        Purified recombinant Human TLR3 protein
 Expression System: 293 cells
 Bioactivity: Determined by its ability to inhibit IL-8 secretion induced by Poly I:C in the TLR3 receptor-expressing HEK293 cells (HEK293 TLR3r). The ED50for this effect is ? 30 µg/mL in the presence of 100 µg/mL of Poly I:C.
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                                            Endotoxin-Niveau
- < 0.1 ng per µg (1 EU/µg).
 
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                                            Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Lyophilized
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                                            Buffer
- Supplied as a lyophilized powder.
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                                            Handhabung
- Avoid repeated freeze/thaw cycles.
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                                            Lagerung
- 4 °C/-20 °C
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                                            Informationen zur Lagerung
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
 
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    - TLR3 (Toll-Like Receptor 3 (TLR3))
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                                            Andere Bezeichnung
- TLR3
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                                            Hintergrund
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                        TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-?B pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. 
 Alternative Names: TLR3, CD283 antigen protein, TLR-3 protein, TLR-3, Toll-like receptor 3, TLR 3 protein, TLR-3 protein, TLR 3
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                                            Molekulargewicht
- 77 kDa
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                                            Pathways
- TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
 Target
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