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NGFB Protein

Dieses Recombinant NGFB-Protein wird in HEK-293 Cells produziert.
Produktnummer ABIN7455640

Kurzübersicht für NGFB Protein (ABIN7455640)

Target

Alle NGFB Proteine anzeigen
NGFB (Nerve Growth Factor beta (NGFB))

Protein-Typ

Recombinant

Spezies

  • 15
  • 10
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 17
  • 8
  • 2
  • 2
  • 2
  • 1
  • 1
HEK-293 Cells

Reinheit

Greater than 95 % as determined by reducing SDS-PAGE.
  • Verwendungszweck

    Recombinant Human Beta-Nerve Growth Factor is produced by our Mammalian expression system and the target gene encoding Ser122-Arg239 is expressed.

    Produktmerkmale

    Extracellular Domain Protein

    Aufreinigung

    Purified from cell culture supernatant by affinity chromatography
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Buffer

    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 250 mM NaCl, pH 7.0.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

    Haltbarkeit

    12 months
  • Target

    NGFB (Nerve Growth Factor beta (NGFB))

    Andere Bezeichnung

    Beta-NGF

    Hintergrund

    Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits a, β, and γ, it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90 % sequence similarity with mouse protein and shows cross-species reactivity.

    Molekulargewicht

    13.3 KDa

    UniProt

    P01138

    Pathways

    NF-kappaB Signalweg, RTK Signalweg, Regulation of Cell Size
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