NGFB Protein
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- Target Alle NGFB Proteine anzeigen
- NGFB (Nerve Growth Factor beta (NGFB))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Maus
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Quelle
- Escherichia coli (E. coli)
- Verwendungszweck
- Recombinant Mouse β-NGF/NGFB Protein (aa 130-239)(Active)
- Sequenz
- Met130-Arg239
- Produktmerkmale
- Recombinant Mouse beta-Nerve Growth Factor is produced by our E.coli expression system and the target gene encoding Met130-Arg239 is expressed.
- Reinheit
- > 95 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.5-1.5 ng/ml.
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,200 mM NaCl, pH 8.0.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- NGFB (Nerve Growth Factor beta (NGFB))
- Andere Bezeichnung
- beta-NGF/NGFB (NGFB Produkte)
- Synonyme
- NGFB Protein, ngfb Protein, ns:zft386 Protein, xx:zft386 Protein, zgc:109730 Protein, hsan5 Protein, beta-ngf Protein, Ngfb Protein, Beta-NGF Protein, HSAN5 Protein, beta-NGF Protein, nerve growth factor Protein, nerve growth factor b (beta polypeptide) Protein, beta-Nerve growth factor Protein, nerve growth factor (beta polypeptide) Protein, NGF Protein, ngfb Protein, FPV072 Protein, FPV076 Protein, ngf Protein, Ngf Protein
- Hintergrund
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Background: NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90 % homology at the amino acid level with human beta -NGF and 95.8 % with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection and repair. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.
Synonym: Beta-Nerve Growth Factor, Beta-NGF, NGF, NGFB
- Molekulargewicht
- 12.4 kDa
- UniProt
- P01139
- Pathways
- NF-kappaB Signalweg, RTK Signalweg, Regulation of Cell Size
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