IL4 Receptor Protein (AA 24-232) (Fc Tag)

Produktnummer ABIN7274993

Recombinant IL4 Receptor-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für IL4 Receptor Protein (AA 24-232) (Fc Tag) (ABIN7274993)

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Produktdetails

Proteineigenschaft: AA 24-232

Aufreinigungstag / Konjugat: Dieses IL4 Receptor Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Human IL-4 R alpha/CD124 Protein

Sequenz: Gly24-His232

Produktmerkmale: Recombinant Human IL-4 R alpha/CD124 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gly24-His232.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human IL-4, No Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human IL-4 R alpha, hFc Tag with the EC50 of 9.8ng/ml determined by ELISA. See testing image for detail.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 24 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Andere Bezeichnung: IL-4 R alpha

Hintergrund: Interleukin 4 Receptor alpha (IL-4 Ra), also known as CD124 and BSF receptor, is a widely expressed 140 kDa transmembrane glycoprotein in the class I cytokine receptor family.The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells.

Molekulargewicht: 50.7 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.

UniProt: P24394-1

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process