CD40 Protein (CD40) (AA 1-193) (His tag)

Produktnummer ABIN7321208

Dieses Recombinant CD40-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CD40 Protein (CD40) (AA 1-193) (His tag) (ABIN7321208)

Target: CD40

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 1-193

Aufreinigungstag / Konjugat: Dieses CD40 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rat CD40/TNFRSF5 Protein (His Tag)

Sequenz: Met1-Arg193

Produktmerkmale: A DNA sequence encoding the rat CD40 (Met1-Arg193) was expressed, fused with a polyhistidine tag at the C-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: CD40

Andere Bezeichnung: CD40/TNFRSF5

Hintergrund: CD40,Tnfrsf5,CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Molekulargewicht:

Calculated MW: 20.6 kDa

Observed MW: 28 kDa

NCBI Accession: NP_599187

UniProt: A0A8I6A2T5

Pathways: NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints