PARP1 Protein (AA 662-1014)
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- Target Alle PARP1 Proteine anzeigen
- PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 662-1014
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Applikation
- SDS-PAGE (SDS)
- Produktmerkmale
- PARP1, 662-1014aa, Human, E.coli
- Reinheit
- > 95 % by SDS-PAGE
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Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 1-100) protein (GST tag)
PARP1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Poly (ADP-Ribose) Polymerase 1 (PARP1) (N-Term) proteinPARP1 Spezies: Human Wirt: Escherichia coli (E. coli) Ct
Poly (ADP-Ribose) Polymerase 1 (PARP1) protein (DYKDDDDK Tag)PARP1 Spezies: Human Wirt: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Poly (ADP-Ribose) Polymerase 1 (PARP1) protein (Myc-DYKDDDDK Tag)PARP1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris buffer(pH 8.0) containing 10% glycerol 1mM DTT.
- Lagerung
- 4 °C
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- Target
- PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
- Andere Bezeichnung
- PARP1 (PARP1 Produkte)
- Hintergrund
- PARP1 is a nuclear DNA-binding zinc finger protein which can exist as a homo- or hetero-dimer, and is strongly activated by DNA strand breaks. This protein involved in chromatin architecture and DNA metabolism, and participates in protein modification to enhance or repress transcription. PARP1 also plays a role in other cellular processes, including cell proliferation and differentiation. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly(ADPribosyl)ation contributes to the efficient maintenance of genome integrity. Recombinant PARP1 protein was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: ADPRT, ADPRT1, pADPRT, pADPRT-1, PARP, PARP-1, PPOL, Poly (ADP-ribose) polymerase family, member 1 ADP ribosyltransferase (NAD+, poly (ADP ribose) polymerase), ADPRT 1, msPARP, NAD(+) ADP ribosyltransferase 1, pADPRT 1, PARP 1, PARP1, Poly (ADP ribose) polymerase 1, poly(ADP ribose) synthetase, poly(ADP ribosyl)transferase, Poly[ADP ribose] synthetase 1, sPARP 1, sPARP1. NCBI no.: AAH37545
- Molekulargewicht
- 39.6 kDa (354aa), confirmed by MALDI-TOF.
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose, DNA Reparatur, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
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