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PARP1 Protein (AA 2-331, partial) (His tag)

PARP1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Produktnummer ABIN5710069
  • Target Alle PARP1 Proteine anzeigen
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 2-331, partial
    Spezies
    • 14
    • 4
    Human
    Quelle
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses PARP1 Protein ist gelabelt mit His tag.
    Applikation
    SDS-PAGE (SDS)
    Sequenz
    FHKAEELFSK TTNNEVDDMD TSDTQWGWFY LAECGKWHMF QPDTNSQCSV SSEDIEKSFK TNPCGSISFT TSKFSYKIDF AEMKQMNLTT GKQRLIKRAP FSISAFSYIC ENEAIPMPPH WENVNTQVPY QLIPLHNQTH EYNEVANLFG KTMDRNRIKR IQRIQNLDLW EFFCRKKAQL KKKRGVPQIN EQMLFHGTSS EFVEAICIHN FDWRINGIHG AVFGKGTYFA RDAAYSSRFC KDDIKHGNTF QIHGVSLQQR HLFRTYKSMF LARVLIGDYI NGDSKYMRPP SKDGSYVNLY DSCVDDTWNP KIFVVFDANQ IYPEYLIDFH
    Aufreinigung
    SDS-PAGE
    Reinheit
    > 90 %
    Top Product
    Discover our top product PARP1 Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Lagerung
    -80 °C,4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Andere Bezeichnung
    PARP1 (PARP1 Produkte)
    Synonyme
    ADPRT Protein, ADPRT 1 Protein, ADPRT1 Protein, ARTD1 Protein, PARP Protein, PARP-1 Protein, PPOL Protein, pADPRT-1 Protein, Adprt Protein, Parp-1 Protein, 5830444G22Rik Protein, AI893648 Protein, Adprp Protein, Adprt1 Protein, C80510 Protein, parp-1 Protein, sPARP-1 Protein, BEST:LD21673 Protein, CG17685 Protein, CG17696 Protein, CG17718 Protein, CG40411 Protein, D.PARP Protein, Dm.pARTa Protein, Dmel\\CG40411 Protein, LD21673.3prime Protein, PARP1 Protein, dPARP Protein, parp Protein, adprt1 Protein, padprt-1 Protein, ppol Protein, si:dkey-206f10.3 Protein, wu:fc60f12 Protein, zgc:110092 Protein, poly(ADP-ribose) polymerase 1 Protein, poly (ADP-ribose) polymerase 1 Protein, poly (ADP-ribose) polymerase family, member 1 Protein, Poly-(ADP-ribose) polymerase Protein, poly(ADP-ribose) polymerase 1 L homeolog Protein, PARP1 Protein, Parp1 Protein, Parp Protein, parp1.L Protein, parp1 Protein
    Hintergrund
    Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
    Molekulargewicht
    42.7 kDa
    UniProt
    P09874
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, DNA Reparatur, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
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