MEK2 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2725471

Produktdetails

Target: MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses MEK2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human MAPKK 2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))

Andere Bezeichnung: Mapkk 2 (MAP2K2 Produkte)

Synonyme: CFC4 Protein, MAPKK2 Protein, MEK2 Protein, MKK2 Protein, PRKMK2 Protein, AA589381 Protein, MK2 Protein, Prkmk2 Protein, ATMKK2 Protein, F27B13.50 Protein, F27B13_50 Protein, MAP KINASE KINASE 1 Protein, MAP kinase kinase 2 Protein, MK1 Protein, map2k2 Protein, wu:fa56c06 Protein, zgc:123171 Protein, zgc:172250 Protein, mitogen-activated protein kinase kinase 2 Protein, mitogen activated protein kinase kinase 2 Protein, MAP kinase kinase 2 Protein, mitogen-activated protein kinase kinase 2a Protein, mitogen-activated protein kinase kinase 2b Protein, MAP2K2 Protein, Map2k2 Protein, MKK2 Protein, map2k2a Protein, map2k2b Protein

Hintergrund: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Molekulargewicht: 44.2 kDa

NCBI Accession: NP_109587

Pathways: MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling