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IL-6 Protein (AA 30-212)

Recombinant IL-6-Protein exprimiert in HEK-293 Cells und wurde in 4+ Publikationen erwähnt.
Produktnummer ABIN2181322

Kurzübersicht für IL-6 Protein (AA 30-212) (ABIN2181322)

Target

Alle IL-6 (IL6) Proteine anzeigen
IL-6 (IL6) (Interleukin 6 (IL6))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 38
  • 22
  • 14
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 58
  • 24
  • 19
  • 8
  • 6
  • 4
  • 1
  • 1
  • 1
HEK-293 Cells

Reinheit

>90 % as determined by SDS-PAGE.
  • Proteineigenschaft

    AA 30-212

    Marke

    ActiveMax®

    Sequenz

    AA 30-212

    Produktmerkmale

    This protein carries no "tag". The protein has a calculated MW of 20.8 kDa. The protein migrates as 24-27 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

    Sterilität

    0.22 μm filtered

    Endotoxin-Niveau

    Less than 1.0 EU per μg by the LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Buffer

    PBS, pH 7.4

    Handhabung

    Please avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Gao, Lu, Guo, Xin: "Dual-optofluidic waveguide in-line fiber biosensor for real-time label-free detection of interferon-gamma with temperature compensation." in: Optics express, Vol. 28, Issue 7, pp. 10491-10504, (2021) (PubMed).

    Lichtor, Chen, Elowe, Chen, Liu: "Side chain determinants of biopolymer function during selection and replication." in: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).

    Hao, Pan, Huang, Wang, Zhao: "Sensitive detection of lung cancer biomarkers using an aptameric graphene-based nanosensor with enhanced stability." in: Biomedical microdevices, Vol. 21, Issue 3, pp. 65, (2019) (PubMed).

    Hao, Pan, Shao, Lin, Zhao: "Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva." in: Biosensors & bioelectronics, Vol. 134, pp. 16-23, (2019) (PubMed).

  • Target

    IL-6 (IL6) (Interleukin 6 (IL6))

    Andere Bezeichnung

    IL-6

    Hintergrund

    Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

    Molekulargewicht

    20.8 kDa

    NCBI Accession

    NP_000591

    Pathways

    TLR Signalweg, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagie, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
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