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Interleukin 4 Receptor (IL4R) (AA 26-232) (Active) protein (His tag) Protein

IL4R Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN2181320
$308.00
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  • Target Alle IL4 Receptor (IL4R) Proteine anzeigen
    IL4 Receptor (IL4R)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 26-232
    Spezies
    • 18
    • 8
    • 6
    • 4
    • 2
    • 1
    Human
    Quelle
    • 15
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses IL4 Receptor Protein ist gelabelt mit His tag.
    Sequenz
    AA 26-232
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.5 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    IL4 Receptor (IL4R)
    Andere Bezeichnung
    IL-4 R alpha (IL4R Produkte)
    Synonyme
    IL4R, il-4ra, zgc:113063, CD124, IL-4RA, IL4RA, Il4ra, IL4, Il4r, interleukin 4 receptor, interleukin 4 receptor, tandem duplicate 1, interleukin 4 receptor, alpha, IL4R, il4r.1, Il4r, Il4ra
    Hintergrund
    IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2--biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL-13Ra1 to form the type II receptor which is responsive to both IL-4 and IL-13. Interleukin-4 receptor has been shown to interact with SHC1.
    Molekulargewicht
    24.6 kDa
    NCBI Accession
    NP_000409
    Pathways
    JAK-STAT Signalweg, Positive Regulation of Immune Effector Process
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