NGFB Protein (AA 122-239)
Kurzübersicht für NGFB Protein (AA 122-239) (ABIN2115490)
Target
Alle NGFB Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Proteineigenschaft
- AA 122-239
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Verwendungszweck
- Recombinant Human β-Nerve Growth Factor/β-NGF (Ser122-Arg239, Human Cells)
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Sequenz
- SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR
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Produktmerkmale
- Recombinant Human β-Nerve Growth Factor/β-NGF produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Pro99-Lys324) of Human β-NGF.
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Sterilität
- 0.2 μm filtered
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Endotoxin-Niveau
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 250 mM NaCl, pH 7.0.
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Handhabung
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
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Lagerung
- 4 °C/-20 °C/-80 °C
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Informationen zur Lagerung
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- NGFB (Nerve Growth Factor beta (NGFB))
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Andere Bezeichnung
- beta-NGF
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Hintergrund
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Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ, it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90 % sequence similarity with mouse protein and shows cross-species reactivity.
Synonyms: Beta-Nerve Growth Factor, Beta-NGF, NGF, NGFB -
Molekulargewicht
- 13.5 kDa
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UniProt
- P01138
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Pathways
- NF-kappaB Signalweg, RTK Signalweg, Regulation of Cell Size
Target
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