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NGFB Protein (AA 122-239)

Dieses Recombinant NGFB-Protein wird in Human Cells produziert.
Produktnummer ABIN2115490

Kurzübersicht für NGFB Protein (AA 122-239) (ABIN2115490)

Target

Alle NGFB Proteine anzeigen
NGFB (Nerve Growth Factor beta (NGFB))

Protein-Typ

Recombinant

Spezies

  • 15
  • 10
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 17
  • 8
  • 3
  • 2
  • 1
  • 1
  • 1
Human Cells

Reinheit

> 95 % as determined by reducing SDS-PAGE.
  • Proteineigenschaft

    AA 122-239

    Verwendungszweck

    Recombinant Human β-Nerve Growth Factor/β-NGF (Ser122-Arg239, Human Cells)

    Sequenz

    SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR

    Produktmerkmale

    Recombinant Human β-Nerve Growth Factor/β-NGF produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Pro99-Lys324) of Human β-NGF.

    Sterilität

    0.2 μm filtered

    Endotoxin-Niveau

    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    Buffer

    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 250 mM NaCl, pH 7.0.

    Handhabung

    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

    Lagerung

    4 °C/-20 °C/-80 °C

    Informationen zur Lagerung

    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    NGFB (Nerve Growth Factor beta (NGFB))

    Andere Bezeichnung

    beta-NGF

    Hintergrund

    Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ, it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90 % sequence similarity with mouse protein and shows cross-species reactivity.
    Synonyms: Beta-Nerve Growth Factor, Beta-NGF, NGF, NGFB

    Molekulargewicht

    13.5 kDa

    UniProt

    P01138

    Pathways

    NF-kappaB Signalweg, RTK Signalweg, Regulation of Cell Size
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