IL4 Receptor Protein (AA 24-232)

Produktnummer ABIN2018122

Dieses Recombinant IL4 Receptor-Protein wird in HEK-293T Cells produziert.

Kurzübersicht für IL4 Receptor Protein (AA 24-232) (ABIN2018122)

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293T Cells

Reinheit: > 95 % as analyzed by SDS-PAGE and HPLC.

Produktdetails

Proteineigenschaft: AA 24-232

Produktmerkmale: ED50 < 70 ng/mL, measured in a neutralization assay using TF-1 cells in the presence of 0.5 ng/mL h-IL-4.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant Human Interleukin-4 Receptor remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Interleukin-4 Receptor should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Andere Bezeichnung: Interleukin-4 Receptor

Hintergrund: Interleukin-4 Receptor, also known as IL-4RA and CD124, is a transmembrane glycoprotein belonging to the class I receptor family. It is highly expressed by activated T-cells. IL-4RA couples with gamma chain to form the type I receptor for IL-4. The extracellular domain of IL-4RA binds to IL-4 and antagonizes its activity. IL-4RA plays an important role in Th2 cell differentiation, Ig class switching and alternative macrophage activation. It has also been implicated in allergic inflammation, tumor progression and atherogenesis.
Synonyms: IL-4R, IL-4RA, CD124

Molekulargewicht: 40-45 kDa, observed by reducing SDS-PAGE.

UniProt: P24394

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process